| Full name: interferon alpha inducible protein 6 | Alias Symbol: IFI616|FAM14C|6-16|IFI-6-16 | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 2537 | HGNC ID: HGNC:4054 | Ensembl Gene: ENSG00000126709 | OMIM ID: 147572 |
| Drug and gene relationship at DGIdb | |||
Expression of IFI6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFI6 | 2537 | 204415_at | 0.8951 | 0.5301 | |
| GSE20347 | IFI6 | 2537 | 204415_at | 1.7743 | 0.0000 | |
| GSE23400 | IFI6 | 2537 | 204415_at | 1.2926 | 0.0000 | |
| GSE26886 | IFI6 | 2537 | 204415_at | 2.0709 | 0.0000 | |
| GSE29001 | IFI6 | 2537 | 204415_at | 2.5380 | 0.0000 | |
| GSE38129 | IFI6 | 2537 | 204415_at | 1.7759 | 0.0001 | |
| GSE45670 | IFI6 | 2537 | 204415_at | 3.2760 | 0.0000 | |
| GSE53622 | IFI6 | 2537 | 57070 | 1.7518 | 0.0000 | |
| GSE53624 | IFI6 | 2537 | 57070 | 2.1766 | 0.0000 | |
| GSE63941 | IFI6 | 2537 | 204415_at | -1.4577 | 0.2059 | |
| GSE77861 | IFI6 | 2537 | 204415_at | 1.7063 | 0.0168 | |
| GSE97050 | IFI6 | 2537 | A_23_P201459 | 0.6960 | 0.1822 | |
| SRP007169 | IFI6 | 2537 | RNAseq | 4.5326 | 0.0000 | |
| SRP008496 | IFI6 | 2537 | RNAseq | 3.8061 | 0.0000 | |
| SRP064894 | IFI6 | 2537 | RNAseq | 3.6500 | 0.0000 | |
| SRP133303 | IFI6 | 2537 | RNAseq | 2.3386 | 0.0000 | |
| SRP159526 | IFI6 | 2537 | RNAseq | -0.0756 | 0.9274 | |
| SRP193095 | IFI6 | 2537 | RNAseq | 2.8035 | 0.0000 | |
| SRP219564 | IFI6 | 2537 | RNAseq | 1.4150 | 0.1649 | |
| TCGA | IFI6 | 2537 | RNAseq | 0.6609 | 0.0000 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by IFI6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IFI6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFI6 | 2537 | 0 | 6 | 24 | |
| GSE20123 | IFI6 | 2537 | 0 | 5 | 25 | |
| GSE43470 | IFI6 | 2537 | 3 | 6 | 34 | |
| GSE46452 | IFI6 | 2537 | 5 | 1 | 53 | |
| GSE47630 | IFI6 | 2537 | 8 | 3 | 29 | |
| GSE54993 | IFI6 | 2537 | 2 | 1 | 67 | |
| GSE54994 | IFI6 | 2537 | 10 | 4 | 39 | |
| GSE60625 | IFI6 | 2537 | 0 | 0 | 11 | |
| GSE74703 | IFI6 | 2537 | 2 | 4 | 30 | |
| GSE74704 | IFI6 | 2537 | 0 | 0 | 20 | |
| TCGA | IFI6 | 2537 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.
Somatic mutations of IFI6:
Generating mutation plots.
Highly correlated genes for IFI6:
Showing top 20/1418 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFI6 | ISG15 | 0.868504 | 13 | 0 | 13 |
| IFI6 | USP41 | 0.843524 | 3 | 0 | 3 |
| IFI6 | IFIT1 | 0.820502 | 13 | 0 | 13 |
| IFI6 | IFI44 | 0.808509 | 13 | 0 | 11 |
| IFI6 | IFI44L | 0.807032 | 13 | 0 | 13 |
| IFI6 | IFI35 | 0.805618 | 13 | 0 | 13 |
| IFI6 | DDX60 | 0.785905 | 13 | 0 | 13 |
| IFI6 | XAF1 | 0.777301 | 12 | 0 | 12 |
| IFI6 | FCGR3A | 0.773109 | 3 | 0 | 3 |
| IFI6 | RSAD2 | 0.770318 | 13 | 0 | 12 |
| IFI6 | STAT1 | 0.764991 | 13 | 0 | 13 |
| IFI6 | ADAR | 0.762074 | 12 | 0 | 11 |
| IFI6 | IRF9 | 0.759976 | 10 | 0 | 10 |
| IFI6 | IFITM1 | 0.756417 | 11 | 0 | 10 |
| IFI6 | OAS2 | 0.756372 | 11 | 0 | 11 |
| IFI6 | HERC5 | 0.75563 | 12 | 0 | 11 |
| IFI6 | PARP12 | 0.753251 | 13 | 0 | 12 |
| IFI6 | USP18 | 0.745193 | 12 | 0 | 12 |
| IFI6 | IFIT3 | 0.743676 | 13 | 0 | 12 |
| IFI6 | DDX60L | 0.740847 | 7 | 0 | 7 |
For details and further investigation, click here
