| Full name: killer cell lectin like receptor C4 | Alias Symbol: NKG2-F | ||
| Type: protein-coding gene | Cytoband: 12p13.2 | ||
| Entrez ID: 8302 | HGNC ID: HGNC:6377 | Ensembl Gene: ENSG00000183542 | OMIM ID: 602893 |
| Drug and gene relationship at DGIdb | |||
KLRC4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation |
Expression of KLRC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLRC4 | 8302 | 210690_at | 0.2811 | 0.6809 | |
| GSE20347 | KLRC4 | 8302 | 210690_at | -0.0457 | 0.3710 | |
| GSE23400 | KLRC4 | 8302 | 210690_at | -0.0006 | 0.9642 | |
| GSE26886 | KLRC4 | 8302 | 210690_at | 0.0282 | 0.7290 | |
| GSE29001 | KLRC4 | 8302 | 210690_at | 0.0758 | 0.7438 | |
| GSE38129 | KLRC4 | 8302 | 210690_at | -0.0383 | 0.3483 | |
| GSE45670 | KLRC4 | 8302 | 210690_at | -0.0666 | 0.3868 | |
| GSE63941 | KLRC4 | 8302 | 210690_at | -0.0326 | 0.8325 | |
| GSE77861 | KLRC4 | 8302 | 210690_at | -0.0634 | 0.4288 | |
| GSE97050 | KLRC4 | 8302 | A_23_P218058 | 0.0172 | 0.9821 | |
| SRP133303 | KLRC4 | 8302 | RNAseq | -0.7170 | 0.0717 | |
| TCGA | KLRC4 | 8302 | RNAseq | -0.6818 | 0.3819 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLRC4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KLRC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLRC4 | 8302 | 6 | 2 | 22 | |
| GSE20123 | KLRC4 | 8302 | 6 | 2 | 22 | |
| GSE43470 | KLRC4 | 8302 | 9 | 3 | 31 | |
| GSE46452 | KLRC4 | 8302 | 10 | 1 | 48 | |
| GSE47630 | KLRC4 | 8302 | 14 | 2 | 24 | |
| GSE54993 | KLRC4 | 8302 | 1 | 10 | 59 | |
| GSE54994 | KLRC4 | 8302 | 9 | 2 | 42 | |
| GSE60625 | KLRC4 | 8302 | 0 | 1 | 10 | |
| GSE74703 | KLRC4 | 8302 | 9 | 2 | 25 | |
| GSE74704 | KLRC4 | 8302 | 4 | 1 | 15 | |
| TCGA | KLRC4 | 8302 | 39 | 6 | 51 |
Total number of gains: 107; Total number of losses: 32; Total Number of normals: 349.
Somatic mutations of KLRC4:
Generating mutation plots.
Highly correlated genes for KLRC4:
Showing top 20/55 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLRC4 | OAS1 | 0.683752 | 3 | 0 | 3 |
| KLRC4 | DDX58 | 0.675505 | 3 | 0 | 3 |
| KLRC4 | IFIH1 | 0.668969 | 3 | 0 | 3 |
| KLRC4 | SRP19 | 0.666137 | 3 | 0 | 3 |
| KLRC4 | GBP5 | 0.666083 | 3 | 0 | 3 |
| KLRC4 | IFNG | 0.658022 | 4 | 0 | 3 |
| KLRC4 | PPP6R1 | 0.639809 | 3 | 0 | 3 |
| KLRC4 | XYLB | 0.6332 | 4 | 0 | 3 |
| KLRC4 | GBA3 | 0.622274 | 3 | 0 | 3 |
| KLRC4 | CXCL10 | 0.621002 | 3 | 0 | 3 |
| KLRC4 | RASSF4 | 0.615761 | 3 | 0 | 3 |
| KLRC4 | CCR5 | 0.610742 | 3 | 0 | 3 |
| KLRC4 | EIF3M | 0.609436 | 3 | 0 | 3 |
| KLRC4 | CMA1 | 0.598586 | 3 | 0 | 3 |
| KLRC4 | RPL24 | 0.596524 | 3 | 0 | 3 |
| KLRC4 | KRTAP4-7 | 0.591955 | 3 | 0 | 3 |
| KLRC4 | PRR34 | 0.584681 | 3 | 0 | 3 |
| KLRC4 | JARID2 | 0.584679 | 3 | 0 | 3 |
| KLRC4 | BTN2A2 | 0.584668 | 4 | 0 | 4 |
| KLRC4 | AKAP5 | 0.581307 | 5 | 0 | 3 |
For details and further investigation, click here
