| Full name: DEF6 guanine nucleotide exchange factor | Alias Symbol: IBP|SLAT|SWAP70L | ||
| Type: protein-coding gene | Cytoband: 6p21.31 | ||
| Entrez ID: 50619 | HGNC ID: HGNC:2760 | Ensembl Gene: ENSG00000023892 | OMIM ID: 610094 |
| Drug and gene relationship at DGIdb | |||
Expression of DEF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEF6 | 50619 | 226659_at | 0.2170 | 0.7338 | |
| GSE20347 | DEF6 | 50619 | 221293_s_at | -0.2481 | 0.0157 | |
| GSE23400 | DEF6 | 50619 | 221293_s_at | -0.1073 | 0.0315 | |
| GSE26886 | DEF6 | 50619 | 226659_at | 0.3871 | 0.0150 | |
| GSE29001 | DEF6 | 50619 | 221293_s_at | -0.0167 | 0.9240 | |
| GSE38129 | DEF6 | 50619 | 221293_s_at | -0.1929 | 0.0832 | |
| GSE45670 | DEF6 | 50619 | 226659_at | 0.2026 | 0.1610 | |
| GSE53622 | DEF6 | 50619 | 109145 | -1.9800 | 0.0000 | |
| GSE53624 | DEF6 | 50619 | 109145 | -2.0314 | 0.0000 | |
| GSE63941 | DEF6 | 50619 | 226659_at | 2.3552 | 0.0002 | |
| GSE77861 | DEF6 | 50619 | 226659_at | -0.3016 | 0.0331 | |
| GSE97050 | DEF6 | 50619 | A_23_P321913 | -1.0127 | 0.2707 | |
| SRP007169 | DEF6 | 50619 | RNAseq | -0.4560 | 0.2562 | |
| SRP008496 | DEF6 | 50619 | RNAseq | -0.4416 | 0.0987 | |
| SRP064894 | DEF6 | 50619 | RNAseq | 0.3235 | 0.1607 | |
| SRP133303 | DEF6 | 50619 | RNAseq | -0.5329 | 0.0044 | |
| SRP159526 | DEF6 | 50619 | RNAseq | -0.6422 | 0.0326 | |
| SRP193095 | DEF6 | 50619 | RNAseq | -0.1670 | 0.2144 | |
| SRP219564 | DEF6 | 50619 | RNAseq | 0.2049 | 0.7627 | |
| TCGA | DEF6 | 50619 | RNAseq | 0.2059 | 0.0136 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by DEF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEF6 | 50619 | 5 | 0 | 25 | |
| GSE20123 | DEF6 | 50619 | 5 | 0 | 25 | |
| GSE43470 | DEF6 | 50619 | 6 | 1 | 36 | |
| GSE46452 | DEF6 | 50619 | 2 | 9 | 48 | |
| GSE47630 | DEF6 | 50619 | 8 | 4 | 28 | |
| GSE54993 | DEF6 | 50619 | 3 | 1 | 66 | |
| GSE54994 | DEF6 | 50619 | 11 | 4 | 38 | |
| GSE60625 | DEF6 | 50619 | 1 | 0 | 10 | |
| GSE74703 | DEF6 | 50619 | 6 | 0 | 30 | |
| GSE74704 | DEF6 | 50619 | 2 | 0 | 18 | |
| TCGA | DEF6 | 50619 | 16 | 15 | 65 |
Total number of gains: 65; Total number of losses: 34; Total Number of normals: 389.
Somatic mutations of DEF6:
Generating mutation plots.
Highly correlated genes for DEF6:
Showing top 20/270 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEF6 | IQCF1 | 0.85264 | 3 | 0 | 3 |
| DEF6 | NCCRP1 | 0.825491 | 3 | 0 | 3 |
| DEF6 | KRTAP20-1 | 0.808593 | 3 | 0 | 3 |
| DEF6 | TMPRSS11A | 0.798978 | 3 | 0 | 3 |
| DEF6 | C1orf87 | 0.790874 | 3 | 0 | 3 |
| DEF6 | OR2Z1 | 0.780344 | 3 | 0 | 3 |
| DEF6 | FAM163B | 0.778642 | 3 | 0 | 3 |
| DEF6 | KPRP | 0.767341 | 3 | 0 | 3 |
| DEF6 | OTOP3 | 0.767316 | 3 | 0 | 3 |
| DEF6 | MFSD2B | 0.762679 | 3 | 0 | 3 |
| DEF6 | GALNT9 | 0.747222 | 3 | 0 | 3 |
| DEF6 | MOV10L1 | 0.735544 | 3 | 0 | 3 |
| DEF6 | UPK3B | 0.73554 | 3 | 0 | 3 |
| DEF6 | MUC22 | 0.732716 | 3 | 0 | 3 |
| DEF6 | ANKRD31 | 0.730368 | 3 | 0 | 3 |
| DEF6 | CYP2C8 | 0.721827 | 4 | 0 | 4 |
| DEF6 | ESYT3 | 0.720169 | 3 | 0 | 3 |
| DEF6 | MORN3 | 0.719692 | 5 | 0 | 4 |
| DEF6 | RNF222 | 0.714709 | 3 | 0 | 3 |
| DEF6 | ARHGAP40 | 0.710762 | 3 | 0 | 3 |
For details and further investigation, click here
