| Full name: cytochrome P450 family 2 subfamily C member 8 | Alias Symbol: CPC8 | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 1558 | HGNC ID: HGNC:2622 | Ensembl Gene: ENSG00000138115 | OMIM ID: 601129 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2C8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2C8 | 1558 | 219903_s_at | 0.0392 | 0.8800 | |
| GSE20347 | CYP2C8 | 1558 | 219903_s_at | 0.0730 | 0.2155 | |
| GSE23400 | CYP2C8 | 1558 | 219903_s_at | -0.0878 | 0.0073 | |
| GSE26886 | CYP2C8 | 1558 | 219903_s_at | -0.0748 | 0.4442 | |
| GSE29001 | CYP2C8 | 1558 | 208147_s_at | -0.0808 | 0.7901 | |
| GSE38129 | CYP2C8 | 1558 | 219903_s_at | -0.0132 | 0.8405 | |
| GSE45670 | CYP2C8 | 1558 | 219903_s_at | -0.0086 | 0.9277 | |
| GSE53622 | CYP2C8 | 1558 | 47239 | -2.4881 | 0.0000 | |
| GSE53624 | CYP2C8 | 1558 | 47239 | -2.6378 | 0.0000 | |
| GSE63941 | CYP2C8 | 1558 | 219903_s_at | 0.0778 | 0.5619 | |
| GSE77861 | CYP2C8 | 1558 | 219903_s_at | 0.0425 | 0.5837 | |
| GSE97050 | CYP2C8 | 1558 | A_23_P161368 | -0.8745 | 0.1512 | |
| TCGA | CYP2C8 | 1558 | RNAseq | -2.9451 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CYP2C8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2C8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2C8 | 1558 | 1 | 8 | 21 | |
| GSE20123 | CYP2C8 | 1558 | 1 | 7 | 22 | |
| GSE43470 | CYP2C8 | 1558 | 0 | 7 | 36 | |
| GSE46452 | CYP2C8 | 1558 | 0 | 11 | 48 | |
| GSE47630 | CYP2C8 | 1558 | 2 | 14 | 24 | |
| GSE54993 | CYP2C8 | 1558 | 7 | 0 | 63 | |
| GSE54994 | CYP2C8 | 1558 | 2 | 10 | 41 | |
| GSE60625 | CYP2C8 | 1558 | 0 | 0 | 11 | |
| GSE74703 | CYP2C8 | 1558 | 0 | 5 | 31 | |
| GSE74704 | CYP2C8 | 1558 | 0 | 4 | 16 | |
| TCGA | CYP2C8 | 1558 | 6 | 26 | 64 |
Total number of gains: 19; Total number of losses: 92; Total Number of normals: 377.
Somatic mutations of CYP2C8:
Generating mutation plots.
Highly correlated genes for CYP2C8:
Showing top 20/448 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2C8 | CEACAM5 | 0.829056 | 3 | 0 | 3 |
| CYP2C8 | EMP1 | 0.828499 | 3 | 0 | 3 |
| CYP2C8 | SCEL | 0.821181 | 3 | 0 | 3 |
| CYP2C8 | MAL | 0.81824 | 3 | 0 | 3 |
| CYP2C8 | SPINK5 | 0.814641 | 3 | 0 | 3 |
| CYP2C8 | HOPX | 0.800691 | 3 | 0 | 3 |
| CYP2C8 | NCCRP1 | 0.794097 | 3 | 0 | 3 |
| CYP2C8 | TMPRSS11E | 0.792167 | 3 | 0 | 3 |
| CYP2C8 | CEACAM6 | 0.790526 | 3 | 0 | 3 |
| CYP2C8 | PHACTR2 | 0.784448 | 3 | 0 | 3 |
| CYP2C8 | TMPRSS11B | 0.783902 | 3 | 0 | 3 |
| CYP2C8 | SERPINB1 | 0.783596 | 3 | 0 | 3 |
| CYP2C8 | ANXA1 | 0.779262 | 3 | 0 | 3 |
| CYP2C8 | TMPRSS11A | 0.776938 | 3 | 0 | 3 |
| CYP2C8 | ST6GALNAC1 | 0.776579 | 3 | 0 | 3 |
| CYP2C8 | KRT13 | 0.775202 | 3 | 0 | 3 |
| CYP2C8 | KRT4 | 0.768341 | 3 | 0 | 3 |
| CYP2C8 | STX19 | 0.765663 | 3 | 0 | 3 |
| CYP2C8 | MALL | 0.764571 | 3 | 0 | 3 |
| CYP2C8 | RAB10 | 0.761295 | 3 | 0 | 3 |
For details and further investigation, click here
