| Full name: troponin I1, slow skeletal type | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 7135 | HGNC ID: HGNC:11945 | Ensembl Gene: ENSG00000159173 | OMIM ID: 191042 |
| Drug and gene relationship at DGIdb | |||
Expression of TNNI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNNI1 | 7135 | 205177_at | 0.1858 | 0.3147 | |
| GSE20347 | TNNI1 | 7135 | 205177_at | -0.0067 | 0.9387 | |
| GSE23400 | TNNI1 | 7135 | 205177_at | -0.0378 | 0.5419 | |
| GSE26886 | TNNI1 | 7135 | 205177_at | 0.2943 | 0.0204 | |
| GSE29001 | TNNI1 | 7135 | 205177_at | -0.0930 | 0.4526 | |
| GSE38129 | TNNI1 | 7135 | 205177_at | -0.0575 | 0.3784 | |
| GSE45670 | TNNI1 | 7135 | 205177_at | 0.0320 | 0.7964 | |
| GSE53622 | TNNI1 | 7135 | 80358 | 0.3263 | 0.0123 | |
| GSE53624 | TNNI1 | 7135 | 80358 | 0.2009 | 0.0995 | |
| GSE63941 | TNNI1 | 7135 | 205177_at | 0.2960 | 0.0221 | |
| GSE77861 | TNNI1 | 7135 | 205177_at | -0.0991 | 0.4381 | |
| GSE97050 | TNNI1 | 7135 | A_23_P51565 | -0.7694 | 0.1994 | |
| SRP007169 | TNNI1 | 7135 | RNAseq | 1.0900 | 0.2118 | |
| SRP064894 | TNNI1 | 7135 | RNAseq | 0.5208 | 0.1697 | |
| SRP133303 | TNNI1 | 7135 | RNAseq | 0.2574 | 0.3581 | |
| SRP159526 | TNNI1 | 7135 | RNAseq | 1.3239 | 0.0079 | |
| SRP193095 | TNNI1 | 7135 | RNAseq | 0.3055 | 0.0958 | |
| SRP219564 | TNNI1 | 7135 | RNAseq | 0.3143 | 0.7384 | |
| TCGA | TNNI1 | 7135 | RNAseq | 0.1266 | 0.5507 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TNNI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNNI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNNI1 | 7135 | 11 | 0 | 19 | |
| GSE20123 | TNNI1 | 7135 | 11 | 0 | 19 | |
| GSE43470 | TNNI1 | 7135 | 6 | 0 | 37 | |
| GSE46452 | TNNI1 | 7135 | 3 | 1 | 55 | |
| GSE47630 | TNNI1 | 7135 | 14 | 0 | 26 | |
| GSE54993 | TNNI1 | 7135 | 0 | 6 | 64 | |
| GSE54994 | TNNI1 | 7135 | 15 | 0 | 38 | |
| GSE60625 | TNNI1 | 7135 | 0 | 0 | 11 | |
| GSE74703 | TNNI1 | 7135 | 6 | 0 | 30 | |
| GSE74704 | TNNI1 | 7135 | 5 | 0 | 15 | |
| TCGA | TNNI1 | 7135 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of TNNI1:
Generating mutation plots.
Highly correlated genes for TNNI1:
Showing top 20/755 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNNI1 | DEFB128 | 0.778499 | 3 | 0 | 3 |
| TNNI1 | FAM222A-AS1 | 0.773747 | 3 | 0 | 3 |
| TNNI1 | STRC | 0.758519 | 3 | 0 | 3 |
| TNNI1 | DCDC1 | 0.758295 | 3 | 0 | 3 |
| TNNI1 | OR4D6 | 0.749495 | 3 | 0 | 3 |
| TNNI1 | PLA2G2C | 0.734971 | 3 | 0 | 3 |
| TNNI1 | KRTAP10-12 | 0.728714 | 3 | 0 | 3 |
| TNNI1 | LINC00486 | 0.722282 | 3 | 0 | 3 |
| TNNI1 | NKX6-3 | 0.716341 | 3 | 0 | 3 |
| TNNI1 | BBC3 | 0.709334 | 3 | 0 | 3 |
| TNNI1 | TREM1 | 0.704986 | 3 | 0 | 3 |
| TNNI1 | BAALC | 0.701641 | 4 | 0 | 4 |
| TNNI1 | KCNJ9 | 0.700127 | 5 | 0 | 5 |
| TNNI1 | GOLGA6L6 | 0.694342 | 3 | 0 | 3 |
| TNNI1 | PARD6G-AS1 | 0.684779 | 3 | 0 | 3 |
| TNNI1 | OR2A5 | 0.683781 | 3 | 0 | 3 |
| TNNI1 | NCKAP5L | 0.683262 | 4 | 0 | 4 |
| TNNI1 | NUTM1 | 0.680377 | 4 | 0 | 4 |
| TNNI1 | TRAPPC3L | 0.678896 | 3 | 0 | 3 |
| TNNI1 | DAOA | 0.676639 | 4 | 0 | 4 |
For details and further investigation, click here
