| Full name: delta 4-desaturase, sphingolipid 2 | Alias Symbol: DES2|FADS8 | ||
| Type: protein-coding gene | Cytoband: 14q32.2 | ||
| Entrez ID: 123099 | HGNC ID: HGNC:20113 | Ensembl Gene: ENSG00000168350 | OMIM ID: 610862 |
| Drug and gene relationship at DGIdb | |||
Expression of DEGS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEGS2 | 123099 | 236496_at | -1.7431 | 0.0535 | |
| GSE26886 | DEGS2 | 123099 | 236496_at | -1.5721 | 0.0000 | |
| GSE45670 | DEGS2 | 123099 | 236496_at | -0.6580 | 0.0100 | |
| GSE53622 | DEGS2 | 123099 | 69035 | -2.1134 | 0.0000 | |
| GSE53624 | DEGS2 | 123099 | 69035 | -3.0951 | 0.0000 | |
| GSE63941 | DEGS2 | 123099 | 236496_at | 0.2414 | 0.5663 | |
| GSE77861 | DEGS2 | 123099 | 236496_at | -0.7002 | 0.0115 | |
| GSE97050 | DEGS2 | 123099 | A_33_P3290174 | -0.3368 | 0.2110 | |
| SRP007169 | DEGS2 | 123099 | RNAseq | -5.4009 | 0.0000 | |
| SRP008496 | DEGS2 | 123099 | RNAseq | -4.1787 | 0.0000 | |
| SRP064894 | DEGS2 | 123099 | RNAseq | -2.7946 | 0.0000 | |
| SRP133303 | DEGS2 | 123099 | RNAseq | -2.8762 | 0.0000 | |
| SRP159526 | DEGS2 | 123099 | RNAseq | -3.4296 | 0.0000 | |
| SRP193095 | DEGS2 | 123099 | RNAseq | -2.6934 | 0.0000 | |
| SRP219564 | DEGS2 | 123099 | RNAseq | -3.6086 | 0.0004 | |
| TCGA | DEGS2 | 123099 | RNAseq | -0.6921 | 0.0184 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by DEGS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEGS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEGS2 | 123099 | 9 | 5 | 16 | |
| GSE20123 | DEGS2 | 123099 | 9 | 4 | 17 | |
| GSE43470 | DEGS2 | 123099 | 7 | 4 | 32 | |
| GSE46452 | DEGS2 | 123099 | 17 | 3 | 39 | |
| GSE47630 | DEGS2 | 123099 | 11 | 8 | 21 | |
| GSE54993 | DEGS2 | 123099 | 3 | 8 | 59 | |
| GSE54994 | DEGS2 | 123099 | 21 | 4 | 28 | |
| GSE60625 | DEGS2 | 123099 | 0 | 2 | 9 | |
| GSE74703 | DEGS2 | 123099 | 6 | 3 | 27 | |
| GSE74704 | DEGS2 | 123099 | 5 | 3 | 12 | |
| TCGA | DEGS2 | 123099 | 31 | 18 | 47 |
Total number of gains: 119; Total number of losses: 62; Total Number of normals: 307.
Somatic mutations of DEGS2:
Generating mutation plots.
Highly correlated genes for DEGS2:
Showing top 20/1075 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEGS2 | NCCRP1 | 0.906605 | 3 | 0 | 3 |
| DEGS2 | NCR1 | 0.899362 | 3 | 0 | 3 |
| DEGS2 | FAM163B | 0.884026 | 3 | 0 | 3 |
| DEGS2 | ENDOU | 0.856053 | 6 | 0 | 6 |
| DEGS2 | PRSS27 | 0.854589 | 7 | 0 | 7 |
| DEGS2 | VSIG10L | 0.851757 | 7 | 0 | 7 |
| DEGS2 | OTOP3 | 0.848661 | 3 | 0 | 3 |
| DEGS2 | IQCF1 | 0.848613 | 4 | 0 | 4 |
| DEGS2 | GDPD3 | 0.848243 | 7 | 0 | 7 |
| DEGS2 | SLC13A4 | 0.845444 | 7 | 0 | 7 |
| DEGS2 | HCG22 | 0.839388 | 6 | 0 | 6 |
| DEGS2 | CYSRT1 | 0.838484 | 6 | 0 | 6 |
| DEGS2 | RAB25 | 0.837072 | 6 | 0 | 6 |
| DEGS2 | CAPN5 | 0.835762 | 6 | 0 | 6 |
| DEGS2 | TP53I3 | 0.833017 | 6 | 0 | 6 |
| DEGS2 | ACPP | 0.830836 | 7 | 0 | 7 |
| DEGS2 | GYS2 | 0.830457 | 6 | 0 | 6 |
| DEGS2 | EPS8L2 | 0.830384 | 7 | 0 | 7 |
| DEGS2 | ANXA9 | 0.829172 | 6 | 0 | 6 |
| DEGS2 | SMIM5 | 0.828125 | 6 | 0 | 6 |
For details and further investigation, click here
