| Full name: tumor protein p53 inducible protein 3 | Alias Symbol: PIG3 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 9540 | HGNC ID: HGNC:19373 | Ensembl Gene: ENSG00000115129 | OMIM ID: 605171 |
| Drug and gene relationship at DGIdb | |||
TP53I3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway |
Expression of TP53I3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TP53I3 | 9540 | 210609_s_at | -1.7918 | 0.0777 | |
| GSE20347 | TP53I3 | 9540 | 210609_s_at | -2.6333 | 0.0000 | |
| GSE23400 | TP53I3 | 9540 | 210609_s_at | -1.7911 | 0.0000 | |
| GSE26886 | TP53I3 | 9540 | 210609_s_at | -3.1459 | 0.0000 | |
| GSE29001 | TP53I3 | 9540 | 210609_s_at | -2.5980 | 0.0000 | |
| GSE38129 | TP53I3 | 9540 | 210609_s_at | -1.8841 | 0.0000 | |
| GSE45670 | TP53I3 | 9540 | 210609_s_at | -1.2180 | 0.0010 | |
| GSE53622 | TP53I3 | 9540 | 7040 | -1.9519 | 0.0000 | |
| GSE53624 | TP53I3 | 9540 | 7040 | -2.3973 | 0.0000 | |
| GSE63941 | TP53I3 | 9540 | 210609_s_at | -2.2194 | 0.0158 | |
| GSE77861 | TP53I3 | 9540 | 210609_s_at | -1.8329 | 0.0010 | |
| GSE97050 | TP53I3 | 9540 | A_33_P3392077 | -0.3492 | 0.6574 | |
| SRP007169 | TP53I3 | 9540 | RNAseq | -3.9186 | 0.0000 | |
| SRP008496 | TP53I3 | 9540 | RNAseq | -3.3809 | 0.0000 | |
| SRP064894 | TP53I3 | 9540 | RNAseq | -1.7264 | 0.0000 | |
| SRP133303 | TP53I3 | 9540 | RNAseq | -2.0506 | 0.0000 | |
| SRP159526 | TP53I3 | 9540 | RNAseq | -2.1223 | 0.0000 | |
| SRP193095 | TP53I3 | 9540 | RNAseq | -2.1229 | 0.0000 | |
| SRP219564 | TP53I3 | 9540 | RNAseq | -0.7866 | 0.3560 | |
| TCGA | TP53I3 | 9540 | RNAseq | -0.1487 | 0.2783 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by TP53I3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TP53I3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TP53I3 | 9540 | 10 | 2 | 18 | |
| GSE20123 | TP53I3 | 9540 | 10 | 2 | 18 | |
| GSE43470 | TP53I3 | 9540 | 2 | 1 | 40 | |
| GSE46452 | TP53I3 | 9540 | 3 | 4 | 52 | |
| GSE47630 | TP53I3 | 9540 | 8 | 0 | 32 | |
| GSE54993 | TP53I3 | 9540 | 0 | 7 | 63 | |
| GSE54994 | TP53I3 | 9540 | 10 | 0 | 43 | |
| GSE60625 | TP53I3 | 9540 | 0 | 3 | 8 | |
| GSE74703 | TP53I3 | 9540 | 2 | 0 | 34 | |
| GSE74704 | TP53I3 | 9540 | 9 | 1 | 10 | |
| TCGA | TP53I3 | 9540 | 36 | 4 | 56 |
Total number of gains: 90; Total number of losses: 24; Total Number of normals: 374.
Somatic mutations of TP53I3:
Generating mutation plots.
Highly correlated genes for TP53I3:
Showing top 20/1611 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TP53I3 | SFTA2 | 0.897938 | 4 | 0 | 4 |
| TP53I3 | GYS2 | 0.890939 | 10 | 0 | 10 |
| TP53I3 | CYSRT1 | 0.889615 | 6 | 0 | 6 |
| TP53I3 | EPGN | 0.874286 | 3 | 0 | 3 |
| TP53I3 | SLC46A2 | 0.86168 | 6 | 0 | 6 |
| TP53I3 | TMOD3 | 0.860526 | 11 | 0 | 11 |
| TP53I3 | SLC35C1 | 0.860114 | 10 | 0 | 10 |
| TP53I3 | SMAGP | 0.852807 | 11 | 0 | 11 |
| TP53I3 | CWH43 | 0.851944 | 10 | 0 | 10 |
| TP53I3 | RAET1E | 0.85192 | 6 | 0 | 6 |
| TP53I3 | CYP2J2 | 0.84706 | 11 | 0 | 11 |
| TP53I3 | TMEM40 | 0.846305 | 11 | 0 | 11 |
| TP53I3 | RANBP9 | 0.845577 | 11 | 0 | 11 |
| TP53I3 | UBL3 | 0.844687 | 11 | 0 | 11 |
| TP53I3 | SAMD5 | 0.843418 | 7 | 0 | 7 |
| TP53I3 | SH3GL1 | 0.843325 | 11 | 0 | 11 |
| TP53I3 | EPS8L1 | 0.842248 | 12 | 0 | 12 |
| TP53I3 | CHP1 | 0.841957 | 10 | 0 | 10 |
| TP53I3 | CLIC3 | 0.840865 | 10 | 0 | 9 |
| TP53I3 | GDPD3 | 0.840505 | 12 | 0 | 12 |
For details and further investigation, click here
