| Full name: calpain 5 | Alias Symbol: nCL-3|HTRA3|ADNIV | ||
| Type: protein-coding gene | Cytoband: 11q13.5 | ||
| Entrez ID: 726 | HGNC ID: HGNC:1482 | Ensembl Gene: ENSG00000149260 | OMIM ID: 602537 |
| Drug and gene relationship at DGIdb | |||
Expression of CAPN5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CAPN5 | 726 | 226292_at | -1.1092 | 0.0410 | |
| GSE20347 | CAPN5 | 726 | 205166_at | -1.0260 | 0.0000 | |
| GSE23400 | CAPN5 | 726 | 205166_at | -0.8673 | 0.0000 | |
| GSE26886 | CAPN5 | 726 | 226292_at | -2.6365 | 0.0000 | |
| GSE29001 | CAPN5 | 726 | 205166_at | -0.4041 | 0.0177 | |
| GSE38129 | CAPN5 | 726 | 205166_at | -1.0506 | 0.0000 | |
| GSE45670 | CAPN5 | 726 | 226292_at | -1.2436 | 0.0041 | |
| GSE53622 | CAPN5 | 726 | 45590 | -2.3154 | 0.0000 | |
| GSE53624 | CAPN5 | 726 | 45590 | -2.7999 | 0.0000 | |
| GSE63941 | CAPN5 | 726 | 226292_at | -1.2024 | 0.0217 | |
| GSE77861 | CAPN5 | 726 | 226292_at | -1.2066 | 0.0018 | |
| GSE97050 | CAPN5 | 726 | A_33_P3393170 | -0.7499 | 0.1722 | |
| SRP007169 | CAPN5 | 726 | RNAseq | -3.9737 | 0.0000 | |
| SRP008496 | CAPN5 | 726 | RNAseq | -3.8434 | 0.0000 | |
| SRP064894 | CAPN5 | 726 | RNAseq | -2.4695 | 0.0000 | |
| SRP133303 | CAPN5 | 726 | RNAseq | -2.7552 | 0.0000 | |
| SRP159526 | CAPN5 | 726 | RNAseq | -3.5706 | 0.0000 | |
| SRP193095 | CAPN5 | 726 | RNAseq | -2.1688 | 0.0000 | |
| SRP219564 | CAPN5 | 726 | RNAseq | -2.7926 | 0.0000 | |
| TCGA | CAPN5 | 726 | RNAseq | -0.9680 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by CAPN5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CAPN5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CAPN5 | 726 | 5 | 9 | 16 | |
| GSE20123 | CAPN5 | 726 | 5 | 8 | 17 | |
| GSE43470 | CAPN5 | 726 | 3 | 3 | 37 | |
| GSE46452 | CAPN5 | 726 | 7 | 22 | 30 | |
| GSE47630 | CAPN5 | 726 | 5 | 16 | 19 | |
| GSE54993 | CAPN5 | 726 | 8 | 2 | 60 | |
| GSE54994 | CAPN5 | 726 | 7 | 17 | 29 | |
| GSE60625 | CAPN5 | 726 | 4 | 3 | 4 | |
| GSE74703 | CAPN5 | 726 | 2 | 2 | 32 | |
| GSE74704 | CAPN5 | 726 | 3 | 4 | 13 | |
| TCGA | CAPN5 | 726 | 20 | 31 | 45 |
Total number of gains: 69; Total number of losses: 117; Total Number of normals: 302.
Somatic mutations of CAPN5:
Generating mutation plots.
Highly correlated genes for CAPN5:
Showing top 20/1852 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CAPN5 | GBP6 | 0.885138 | 4 | 0 | 4 |
| CAPN5 | KALRN | 0.877259 | 6 | 0 | 6 |
| CAPN5 | VSIG10L | 0.876201 | 6 | 0 | 6 |
| CAPN5 | CYSRT1 | 0.872228 | 6 | 0 | 6 |
| CAPN5 | SMIM5 | 0.871165 | 6 | 0 | 6 |
| CAPN5 | SFTA2 | 0.870169 | 4 | 0 | 4 |
| CAPN5 | SPINK7 | 0.865281 | 6 | 0 | 6 |
| CAPN5 | SCNN1B | 0.853815 | 10 | 0 | 10 |
| CAPN5 | SPNS2 | 0.85175 | 5 | 0 | 5 |
| CAPN5 | SHROOM3 | 0.844229 | 7 | 0 | 7 |
| CAPN5 | SAMD5 | 0.842431 | 7 | 0 | 7 |
| CAPN5 | SNORA68 | 0.840976 | 4 | 0 | 4 |
| CAPN5 | DEGS2 | 0.835762 | 6 | 0 | 6 |
| CAPN5 | IL36A | 0.835533 | 10 | 0 | 10 |
| CAPN5 | SH3BGRL2 | 0.830451 | 8 | 0 | 7 |
| CAPN5 | SLC16A6 | 0.829161 | 11 | 0 | 11 |
| CAPN5 | GYS2 | 0.827575 | 10 | 0 | 10 |
| CAPN5 | PRSS27 | 0.826845 | 7 | 0 | 6 |
| CAPN5 | CAPN14 | 0.826488 | 7 | 0 | 6 |
| CAPN5 | PRSS3 | 0.825371 | 10 | 0 | 10 |
For details and further investigation, click here
