| Full name: DENN domain containing 1C | Alias Symbol: FLJ22757 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 79958 | HGNC ID: HGNC:26225 | Ensembl Gene: ENSG00000205744 | OMIM ID: 613634 |
| Drug and gene relationship at DGIdb | |||
Expression of DENND1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND1C | 79958 | 221080_s_at | 0.3150 | 0.7340 | |
| GSE20347 | DENND1C | 79958 | 221080_s_at | 0.0547 | 0.7247 | |
| GSE23400 | DENND1C | 79958 | 221080_s_at | -0.1176 | 0.0817 | |
| GSE26886 | DENND1C | 79958 | 221080_s_at | -0.0886 | 0.5559 | |
| GSE29001 | DENND1C | 79958 | 221080_s_at | -0.2915 | 0.1309 | |
| GSE38129 | DENND1C | 79958 | 221080_s_at | -0.2316 | 0.2582 | |
| GSE45670 | DENND1C | 79958 | 221080_s_at | -0.0404 | 0.8655 | |
| GSE53622 | DENND1C | 79958 | 156388 | -0.0903 | 0.2599 | |
| GSE53624 | DENND1C | 79958 | 156388 | -0.1437 | 0.0689 | |
| GSE63941 | DENND1C | 79958 | 221080_s_at | 0.2719 | 0.3382 | |
| GSE77861 | DENND1C | 79958 | 221080_s_at | -0.1258 | 0.2860 | |
| GSE97050 | DENND1C | 79958 | A_23_P78608 | 0.3496 | 0.3195 | |
| SRP007169 | DENND1C | 79958 | RNAseq | -0.8437 | 0.1061 | |
| SRP064894 | DENND1C | 79958 | RNAseq | -0.8611 | 0.0002 | |
| SRP133303 | DENND1C | 79958 | RNAseq | -0.9929 | 0.0000 | |
| SRP159526 | DENND1C | 79958 | RNAseq | -1.2912 | 0.0083 | |
| SRP193095 | DENND1C | 79958 | RNAseq | -0.8226 | 0.0001 | |
| SRP219564 | DENND1C | 79958 | RNAseq | -0.9107 | 0.1658 | |
| TCGA | DENND1C | 79958 | RNAseq | -0.2277 | 0.0497 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DENND1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND1C | 79958 | 5 | 3 | 22 | |
| GSE20123 | DENND1C | 79958 | 4 | 2 | 24 | |
| GSE43470 | DENND1C | 79958 | 2 | 6 | 35 | |
| GSE46452 | DENND1C | 79958 | 47 | 1 | 11 | |
| GSE47630 | DENND1C | 79958 | 5 | 7 | 28 | |
| GSE54993 | DENND1C | 79958 | 16 | 3 | 51 | |
| GSE54994 | DENND1C | 79958 | 6 | 14 | 33 | |
| GSE60625 | DENND1C | 79958 | 9 | 0 | 2 | |
| GSE74703 | DENND1C | 79958 | 2 | 4 | 30 | |
| GSE74704 | DENND1C | 79958 | 1 | 2 | 17 | |
| TCGA | DENND1C | 79958 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of DENND1C:
Generating mutation plots.
Highly correlated genes for DENND1C:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND1C | CLECL1 | 0.808794 | 3 | 0 | 3 |
| DENND1C | KHDRBS2 | 0.71235 | 3 | 0 | 3 |
| DENND1C | GPR182 | 0.705796 | 4 | 0 | 4 |
| DENND1C | CRISP1 | 0.698617 | 3 | 0 | 3 |
| DENND1C | TBC1D10C | 0.698425 | 7 | 0 | 6 |
| DENND1C | SERINC2 | 0.698204 | 3 | 0 | 3 |
| DENND1C | IKZF3 | 0.696496 | 8 | 0 | 7 |
| DENND1C | CAMK2B | 0.690065 | 3 | 0 | 3 |
| DENND1C | CYP2A7 | 0.689675 | 3 | 0 | 3 |
| DENND1C | BTNL3 | 0.684944 | 3 | 0 | 3 |
| DENND1C | ADAM30 | 0.679461 | 3 | 0 | 3 |
| DENND1C | FCRL1 | 0.673916 | 4 | 0 | 3 |
| DENND1C | CDH10 | 0.672445 | 6 | 0 | 6 |
| DENND1C | KIR3DL3 | 0.6718 | 5 | 0 | 5 |
| DENND1C | GLDC | 0.670608 | 4 | 0 | 3 |
| DENND1C | SLA2 | 0.664468 | 6 | 0 | 6 |
| DENND1C | LY9 | 0.663165 | 8 | 0 | 7 |
| DENND1C | NCR3 | 0.661872 | 5 | 0 | 4 |
| DENND1C | CD1B | 0.661812 | 4 | 0 | 4 |
| DENND1C | FMNL1 | 0.658583 | 7 | 0 | 7 |
For details and further investigation, click here
