| Full name: IKAROS family zinc finger 3 | Alias Symbol: Aiolos | ||
| Type: protein-coding gene | Cytoband: 17q12-q21.1 | ||
| Entrez ID: 22806 | HGNC ID: HGNC:13178 | Ensembl Gene: ENSG00000161405 | OMIM ID: 606221 |
| Drug and gene relationship at DGIdb | |||
Expression of IKZF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IKZF3 | 22806 | 227030_at | 0.1899 | 0.8383 | |
| GSE20347 | IKZF3 | 22806 | 221092_at | -0.0194 | 0.7578 | |
| GSE23400 | IKZF3 | 22806 | 221092_at | -0.0937 | 0.0010 | |
| GSE26886 | IKZF3 | 22806 | 227030_at | -0.2631 | 0.3812 | |
| GSE29001 | IKZF3 | 22806 | 221092_at | 0.0767 | 0.6931 | |
| GSE38129 | IKZF3 | 22806 | 221092_at | -0.0447 | 0.4271 | |
| GSE45670 | IKZF3 | 22806 | 227030_at | 0.0005 | 0.9985 | |
| GSE53622 | IKZF3 | 22806 | 29889 | -0.3301 | 0.1719 | |
| GSE53624 | IKZF3 | 22806 | 33041 | -0.1879 | 0.0348 | |
| GSE63941 | IKZF3 | 22806 | 227030_at | -0.0368 | 0.8903 | |
| GSE77861 | IKZF3 | 22806 | 227030_at | -0.0339 | 0.8504 | |
| GSE97050 | IKZF3 | 22806 | A_23_P376060 | 1.2124 | 0.2175 | |
| SRP007169 | IKZF3 | 22806 | RNAseq | 0.0514 | 0.9191 | |
| SRP008496 | IKZF3 | 22806 | RNAseq | -0.1918 | 0.6250 | |
| SRP064894 | IKZF3 | 22806 | RNAseq | -0.1812 | 0.4584 | |
| SRP133303 | IKZF3 | 22806 | RNAseq | -0.2516 | 0.2191 | |
| SRP159526 | IKZF3 | 22806 | RNAseq | -1.0850 | 0.1155 | |
| SRP193095 | IKZF3 | 22806 | RNAseq | 0.0112 | 0.9558 | |
| SRP219564 | IKZF3 | 22806 | RNAseq | 0.0401 | 0.9129 | |
| TCGA | IKZF3 | 22806 | RNAseq | -0.2624 | 0.4428 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IKZF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IKZF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IKZF3 | 22806 | 9 | 1 | 20 | |
| GSE20123 | IKZF3 | 22806 | 9 | 1 | 20 | |
| GSE43470 | IKZF3 | 22806 | 1 | 1 | 41 | |
| GSE46452 | IKZF3 | 22806 | 34 | 0 | 25 | |
| GSE47630 | IKZF3 | 22806 | 8 | 1 | 31 | |
| GSE54993 | IKZF3 | 22806 | 3 | 4 | 63 | |
| GSE54994 | IKZF3 | 22806 | 9 | 5 | 39 | |
| GSE60625 | IKZF3 | 22806 | 4 | 0 | 7 | |
| GSE74703 | IKZF3 | 22806 | 1 | 0 | 35 | |
| GSE74704 | IKZF3 | 22806 | 5 | 1 | 14 | |
| TCGA | IKZF3 | 22806 | 23 | 8 | 65 |
Total number of gains: 106; Total number of losses: 22; Total Number of normals: 360.
Somatic mutations of IKZF3:
Generating mutation plots.
Highly correlated genes for IKZF3:
Showing top 20/402 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IKZF3 | TMEM156 | 0.794609 | 4 | 0 | 4 |
| IKZF3 | SLAMF6 | 0.793085 | 5 | 0 | 5 |
| IKZF3 | FCRL3 | 0.790991 | 5 | 0 | 5 |
| IKZF3 | P2RY8 | 0.779272 | 3 | 0 | 3 |
| IKZF3 | GFM1 | 0.776516 | 3 | 0 | 3 |
| IKZF3 | CD3D | 0.754654 | 8 | 0 | 8 |
| IKZF3 | POU2AF1 | 0.745601 | 3 | 0 | 3 |
| IKZF3 | TBC1D10C | 0.7429 | 4 | 0 | 4 |
| IKZF3 | PTPRCAP | 0.720677 | 4 | 0 | 4 |
| IKZF3 | PARVG | 0.71759 | 5 | 0 | 5 |
| IKZF3 | CD19 | 0.712918 | 7 | 0 | 7 |
| IKZF3 | IL25 | 0.703325 | 3 | 0 | 3 |
| IKZF3 | ZAP70 | 0.702195 | 8 | 0 | 7 |
| IKZF3 | IL5RA | 0.701932 | 3 | 0 | 3 |
| IKZF3 | FCRLA | 0.701891 | 5 | 0 | 5 |
| IKZF3 | BTN2A2 | 0.700664 | 5 | 0 | 4 |
| IKZF3 | OSTC | 0.699058 | 3 | 0 | 3 |
| IKZF3 | GK | 0.698782 | 3 | 0 | 3 |
| IKZF3 | CLEC17A | 0.698225 | 3 | 0 | 3 |
| IKZF3 | SEMG2 | 0.697545 | 3 | 0 | 3 |
For details and further investigation, click here
