| Full name: DENN domain containing 5A | Alias Symbol: KIAA1091|FLJ22354|FLJ33829|FLJ43455 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 23258 | HGNC ID: HGNC:19344 | Ensembl Gene: ENSG00000184014 | OMIM ID: 617278 |
| Drug and gene relationship at DGIdb | |||
Expression of DENND5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND5A | 23258 | 212561_at | -0.0751 | 0.9297 | |
| GSE20347 | DENND5A | 23258 | 212561_at | 0.6564 | 0.0002 | |
| GSE23400 | DENND5A | 23258 | 212561_at | 0.3925 | 0.0006 | |
| GSE26886 | DENND5A | 23258 | 212561_at | 1.1773 | 0.0001 | |
| GSE29001 | DENND5A | 23258 | 212561_at | 0.7683 | 0.0085 | |
| GSE38129 | DENND5A | 23258 | 212561_at | 0.2114 | 0.4075 | |
| GSE45670 | DENND5A | 23258 | 212561_at | -0.6488 | 0.0146 | |
| GSE53622 | DENND5A | 23258 | 45427 | 0.3136 | 0.0043 | |
| GSE53624 | DENND5A | 23258 | 45427 | 0.4931 | 0.0000 | |
| GSE63941 | DENND5A | 23258 | 212561_at | -1.8862 | 0.0033 | |
| GSE77861 | DENND5A | 23258 | 212561_at | 0.8703 | 0.0303 | |
| GSE97050 | DENND5A | 23258 | A_23_P321201 | -0.1128 | 0.7299 | |
| SRP007169 | DENND5A | 23258 | RNAseq | 2.2339 | 0.0000 | |
| SRP008496 | DENND5A | 23258 | RNAseq | 2.1722 | 0.0000 | |
| SRP064894 | DENND5A | 23258 | RNAseq | 0.4467 | 0.0672 | |
| SRP133303 | DENND5A | 23258 | RNAseq | 0.4519 | 0.0474 | |
| SRP159526 | DENND5A | 23258 | RNAseq | 0.2194 | 0.3040 | |
| SRP193095 | DENND5A | 23258 | RNAseq | 1.4605 | 0.0000 | |
| SRP219564 | DENND5A | 23258 | RNAseq | -0.1745 | 0.7600 | |
| TCGA | DENND5A | 23258 | RNAseq | -0.0701 | 0.2766 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by DENND5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND5A | 23258 | 0 | 9 | 21 | |
| GSE20123 | DENND5A | 23258 | 0 | 9 | 21 | |
| GSE43470 | DENND5A | 23258 | 1 | 6 | 36 | |
| GSE46452 | DENND5A | 23258 | 7 | 5 | 47 | |
| GSE47630 | DENND5A | 23258 | 2 | 12 | 26 | |
| GSE54993 | DENND5A | 23258 | 3 | 1 | 66 | |
| GSE54994 | DENND5A | 23258 | 2 | 15 | 36 | |
| GSE60625 | DENND5A | 23258 | 0 | 0 | 11 | |
| GSE74703 | DENND5A | 23258 | 1 | 4 | 31 | |
| GSE74704 | DENND5A | 23258 | 0 | 7 | 13 | |
| TCGA | DENND5A | 23258 | 11 | 34 | 51 |
Total number of gains: 27; Total number of losses: 102; Total Number of normals: 359.
Somatic mutations of DENND5A:
Generating mutation plots.
Highly correlated genes for DENND5A:
Showing top 20/1563 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND5A | KRTCAP2 | 0.820809 | 3 | 0 | 3 |
| DENND5A | SSBP4 | 0.78442 | 3 | 0 | 3 |
| DENND5A | ZC3HC1 | 0.767692 | 3 | 0 | 3 |
| DENND5A | MCAM | 0.760521 | 10 | 0 | 10 |
| DENND5A | TRIM47 | 0.760085 | 3 | 0 | 3 |
| DENND5A | PET117 | 0.753114 | 3 | 0 | 3 |
| DENND5A | IGIP | 0.752981 | 3 | 0 | 3 |
| DENND5A | OAZ2 | 0.744686 | 4 | 0 | 4 |
| DENND5A | RAB34 | 0.743752 | 3 | 0 | 3 |
| DENND5A | CHST15 | 0.739664 | 11 | 0 | 11 |
| DENND5A | TOP1MT | 0.738724 | 3 | 0 | 3 |
| DENND5A | SFT2D3 | 0.738331 | 3 | 0 | 3 |
| DENND5A | RAB23 | 0.735394 | 9 | 0 | 9 |
| DENND5A | LAMC1 | 0.734319 | 13 | 0 | 12 |
| DENND5A | FAM126A | 0.729303 | 3 | 0 | 3 |
| DENND5A | CLMP | 0.725799 | 6 | 0 | 6 |
| DENND5A | COL4A2 | 0.724655 | 12 | 0 | 12 |
| DENND5A | FSTL1 | 0.7236 | 13 | 0 | 11 |
| DENND5A | PIF1 | 0.723208 | 3 | 0 | 3 |
| DENND5A | RASSF8 | 0.716119 | 7 | 0 | 7 |
For details and further investigation, click here
