| Full name: DNA topoisomerase I mitochondrial | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 116447 | HGNC ID: HGNC:29787 | Ensembl Gene: ENSG00000184428 | OMIM ID: 606387 |
| Drug and gene relationship at DGIdb | |||
Expression of TOP1MT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TOP1MT | 116447 | 225802_at | 1.2964 | 0.0276 | |
| GSE26886 | TOP1MT | 116447 | 225802_at | 1.6830 | 0.0000 | |
| GSE45670 | TOP1MT | 116447 | 225802_at | 0.6699 | 0.0169 | |
| GSE53622 | TOP1MT | 116447 | 15258 | 0.8902 | 0.0000 | |
| GSE53624 | TOP1MT | 116447 | 15258 | 1.1613 | 0.0000 | |
| GSE63941 | TOP1MT | 116447 | 225802_at | 0.8121 | 0.1645 | |
| GSE77861 | TOP1MT | 116447 | 225802_at | 0.7147 | 0.0287 | |
| GSE97050 | TOP1MT | 116447 | A_24_P248053 | 0.7025 | 0.1287 | |
| SRP007169 | TOP1MT | 116447 | RNAseq | 1.8007 | 0.0167 | |
| SRP008496 | TOP1MT | 116447 | RNAseq | 1.8935 | 0.0000 | |
| SRP064894 | TOP1MT | 116447 | RNAseq | 1.4588 | 0.0000 | |
| SRP133303 | TOP1MT | 116447 | RNAseq | 0.8438 | 0.0006 | |
| SRP159526 | TOP1MT | 116447 | RNAseq | 0.5918 | 0.0153 | |
| SRP193095 | TOP1MT | 116447 | RNAseq | 0.8086 | 0.0000 | |
| SRP219564 | TOP1MT | 116447 | RNAseq | 1.5716 | 0.0098 | |
| TCGA | TOP1MT | 116447 | RNAseq | 0.5113 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by TOP1MT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TOP1MT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TOP1MT | 116447 | 17 | 1 | 12 | |
| GSE20123 | TOP1MT | 116447 | 17 | 1 | 12 | |
| GSE43470 | TOP1MT | 116447 | 17 | 2 | 24 | |
| GSE46452 | TOP1MT | 116447 | 27 | 0 | 32 | |
| GSE47630 | TOP1MT | 116447 | 23 | 1 | 16 | |
| GSE54993 | TOP1MT | 116447 | 0 | 25 | 45 | |
| GSE54994 | TOP1MT | 116447 | 39 | 1 | 13 | |
| GSE60625 | TOP1MT | 116447 | 3 | 4 | 4 | |
| GSE74703 | TOP1MT | 116447 | 15 | 1 | 20 | |
| GSE74704 | TOP1MT | 116447 | 10 | 0 | 10 | |
| TCGA | TOP1MT | 116447 | 64 | 2 | 30 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of TOP1MT:
Generating mutation plots.
Highly correlated genes for TOP1MT:
Showing top 20/2070 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TOP1MT | SLC38A10 | 0.803644 | 4 | 0 | 4 |
| TOP1MT | MRPS28 | 0.801543 | 4 | 0 | 4 |
| TOP1MT | DYNC2H1 | 0.791731 | 3 | 0 | 3 |
| TOP1MT | PUF60 | 0.788622 | 9 | 0 | 8 |
| TOP1MT | DKC1 | 0.784535 | 3 | 0 | 3 |
| TOP1MT | INO80B | 0.778974 | 3 | 0 | 3 |
| TOP1MT | ISY1 | 0.773777 | 3 | 0 | 3 |
| TOP1MT | FTO | 0.770504 | 3 | 0 | 3 |
| TOP1MT | RNF4 | 0.767482 | 3 | 0 | 3 |
| TOP1MT | NAP1L1 | 0.766274 | 3 | 0 | 3 |
| TOP1MT | BOP1 | 0.766239 | 3 | 0 | 3 |
| TOP1MT | PTPN4 | 0.766108 | 4 | 0 | 4 |
| TOP1MT | EXOSC4 | 0.76431 | 9 | 0 | 8 |
| TOP1MT | LRP5L | 0.763923 | 3 | 0 | 3 |
| TOP1MT | LRRC59 | 0.759587 | 3 | 0 | 3 |
| TOP1MT | PTK2 | 0.758161 | 7 | 0 | 7 |
| TOP1MT | SFR1 | 0.756809 | 3 | 0 | 3 |
| TOP1MT | NOP14 | 0.753657 | 5 | 0 | 5 |
| TOP1MT | PFDN2 | 0.751584 | 7 | 0 | 7 |
| TOP1MT | HEATR1 | 0.751431 | 7 | 0 | 7 |
For details and further investigation, click here
