| Full name: collagen type IV alpha 2 chain | Alias Symbol: FLJ22259|DKFZp686I14213 | ||
| Type: protein-coding gene | Cytoband: 13q34 | ||
| Entrez ID: 1284 | HGNC ID: HGNC:2203 | Ensembl Gene: ENSG00000134871 | OMIM ID: 120090 |
| Drug and gene relationship at DGIdb | |||
COL4A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of COL4A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL4A2 | 1284 | 211964_at | 0.6283 | 0.4539 | |
| GSE20347 | COL4A2 | 1284 | 211964_at | 2.1878 | 0.0000 | |
| GSE23400 | COL4A2 | 1284 | 211964_at | 0.9596 | 0.0000 | |
| GSE26886 | COL4A2 | 1284 | 211964_at | 4.0770 | 0.0000 | |
| GSE29001 | COL4A2 | 1284 | 211964_at | 1.7250 | 0.0006 | |
| GSE38129 | COL4A2 | 1284 | 211964_at | 1.4328 | 0.0028 | |
| GSE45670 | COL4A2 | 1284 | 211964_at | 0.2050 | 0.7494 | |
| GSE53622 | COL4A2 | 1284 | 90299 | 1.3939 | 0.0000 | |
| GSE53624 | COL4A2 | 1284 | 90299 | 1.5682 | 0.0000 | |
| GSE63941 | COL4A2 | 1284 | 211964_at | -2.8371 | 0.0835 | |
| GSE77861 | COL4A2 | 1284 | 211964_at | 3.1835 | 0.0011 | |
| GSE97050 | COL4A2 | 1284 | A_23_P205031 | 0.1273 | 0.7206 | |
| SRP007169 | COL4A2 | 1284 | RNAseq | 4.2107 | 0.0000 | |
| SRP008496 | COL4A2 | 1284 | RNAseq | 4.2860 | 0.0000 | |
| SRP064894 | COL4A2 | 1284 | RNAseq | 1.5143 | 0.0000 | |
| SRP133303 | COL4A2 | 1284 | RNAseq | 1.1051 | 0.0009 | |
| SRP159526 | COL4A2 | 1284 | RNAseq | 1.6176 | 0.0029 | |
| SRP193095 | COL4A2 | 1284 | RNAseq | 2.8656 | 0.0000 | |
| SRP219564 | COL4A2 | 1284 | RNAseq | 0.0895 | 0.9026 | |
| TCGA | COL4A2 | 1284 | RNAseq | 0.0648 | 0.4028 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by COL4A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL4A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL4A2 | 1284 | 7 | 11 | 12 | |
| GSE20123 | COL4A2 | 1284 | 7 | 10 | 13 | |
| GSE43470 | COL4A2 | 1284 | 4 | 13 | 26 | |
| GSE46452 | COL4A2 | 1284 | 2 | 31 | 26 | |
| GSE47630 | COL4A2 | 1284 | 3 | 26 | 11 | |
| GSE54993 | COL4A2 | 1284 | 11 | 4 | 55 | |
| GSE54994 | COL4A2 | 1284 | 8 | 8 | 37 | |
| GSE60625 | COL4A2 | 1284 | 0 | 3 | 8 | |
| GSE74703 | COL4A2 | 1284 | 3 | 9 | 24 | |
| GSE74704 | COL4A2 | 1284 | 5 | 9 | 6 | |
| TCGA | COL4A2 | 1284 | 19 | 33 | 44 |
Total number of gains: 69; Total number of losses: 157; Total Number of normals: 262.
Somatic mutations of COL4A2:
Generating mutation plots.
Highly correlated genes for COL4A2:
Showing top 20/1715 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL4A2 | COL4A1 | 0.89443 | 13 | 0 | 13 |
| COL4A2 | LGALS1 | 0.810167 | 12 | 0 | 11 |
| COL4A2 | IGFBP7 | 0.797014 | 12 | 0 | 12 |
| COL4A2 | VCAN | 0.787858 | 12 | 0 | 11 |
| COL4A2 | CALU | 0.78045 | 12 | 0 | 11 |
| COL4A2 | FSTL1 | 0.7747 | 13 | 0 | 11 |
| COL4A2 | FADS1 | 0.774062 | 3 | 0 | 3 |
| COL4A2 | LAMC1 | 0.771192 | 13 | 0 | 11 |
| COL4A2 | COL5A1 | 0.766938 | 12 | 0 | 12 |
| COL4A2 | MMD | 0.760108 | 13 | 0 | 11 |
| COL4A2 | COL12A1 | 0.756934 | 9 | 0 | 8 |
| COL4A2 | PXDN | 0.756705 | 13 | 0 | 12 |
| COL4A2 | FNDC3B | 0.754228 | 11 | 0 | 11 |
| COL4A2 | TMEM263 | 0.753106 | 7 | 0 | 7 |
| COL4A2 | RAI14 | 0.749747 | 12 | 0 | 11 |
| COL4A2 | LBH | 0.748218 | 12 | 0 | 11 |
| COL4A2 | SPARC | 0.747909 | 13 | 0 | 11 |
| COL4A2 | SCYL1 | 0.747751 | 4 | 0 | 3 |
| COL4A2 | ENAH | 0.747735 | 12 | 0 | 12 |
| COL4A2 | RILPL1 | 0.744844 | 4 | 0 | 4 |
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