| Full name: laminin subunit gamma 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 3915 | HGNC ID: HGNC:6492 | Ensembl Gene: ENSG00000135862 | OMIM ID: 150290 |
| Drug and gene relationship at DGIdb | |||
LAMC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa05020 | Prion diseases | |
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer |
Expression of LAMC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAMC1 | 3915 | 200771_at | 0.1751 | 0.8035 | |
| GSE20347 | LAMC1 | 3915 | 200771_at | 1.0499 | 0.0003 | |
| GSE23400 | LAMC1 | 3915 | 200771_at | 0.4866 | 0.0008 | |
| GSE26886 | LAMC1 | 3915 | 200771_at | 2.5680 | 0.0000 | |
| GSE29001 | LAMC1 | 3915 | 200771_at | 0.9437 | 0.0050 | |
| GSE38129 | LAMC1 | 3915 | 200771_at | 0.5395 | 0.0791 | |
| GSE45670 | LAMC1 | 3915 | 200771_at | -0.6580 | 0.0380 | |
| GSE53622 | LAMC1 | 3915 | 28186 | 0.5286 | 0.0000 | |
| GSE53624 | LAMC1 | 3915 | 28186 | 0.7431 | 0.0000 | |
| GSE63941 | LAMC1 | 3915 | 200771_at | -2.2473 | 0.0017 | |
| GSE77861 | LAMC1 | 3915 | 200771_at | 1.5848 | 0.0449 | |
| GSE97050 | LAMC1 | 3915 | A_23_P201628 | -0.1043 | 0.6793 | |
| SRP007169 | LAMC1 | 3915 | RNAseq | 2.9340 | 0.0000 | |
| SRP008496 | LAMC1 | 3915 | RNAseq | 3.6888 | 0.0000 | |
| SRP064894 | LAMC1 | 3915 | RNAseq | 0.6309 | 0.0142 | |
| SRP133303 | LAMC1 | 3915 | RNAseq | 0.6940 | 0.0063 | |
| SRP159526 | LAMC1 | 3915 | RNAseq | 1.0558 | 0.0012 | |
| SRP193095 | LAMC1 | 3915 | RNAseq | 1.9687 | 0.0000 | |
| SRP219564 | LAMC1 | 3915 | RNAseq | 0.0898 | 0.8583 | |
| TCGA | LAMC1 | 3915 | RNAseq | -0.0345 | 0.5793 |
Upregulated datasets: 7; Downregulated datasets: 1.
Survival by LAMC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAMC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAMC1 | 3915 | 13 | 0 | 17 | |
| GSE20123 | LAMC1 | 3915 | 13 | 0 | 17 | |
| GSE43470 | LAMC1 | 3915 | 7 | 1 | 35 | |
| GSE46452 | LAMC1 | 3915 | 3 | 1 | 55 | |
| GSE47630 | LAMC1 | 3915 | 14 | 0 | 26 | |
| GSE54993 | LAMC1 | 3915 | 0 | 6 | 64 | |
| GSE54994 | LAMC1 | 3915 | 15 | 0 | 38 | |
| GSE60625 | LAMC1 | 3915 | 0 | 0 | 11 | |
| GSE74703 | LAMC1 | 3915 | 7 | 1 | 28 | |
| GSE74704 | LAMC1 | 3915 | 6 | 0 | 14 | |
| TCGA | LAMC1 | 3915 | 40 | 3 | 53 |
Total number of gains: 118; Total number of losses: 12; Total Number of normals: 358.
Somatic mutations of LAMC1:
Generating mutation plots.
Highly correlated genes for LAMC1:
Showing top 20/1530 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAMC1 | FSTL1 | 0.812935 | 13 | 0 | 13 |
| LAMC1 | C11orf96 | 0.806017 | 4 | 0 | 4 |
| LAMC1 | IGFBP7 | 0.78992 | 13 | 0 | 12 |
| LAMC1 | ITGB1 | 0.786131 | 13 | 0 | 13 |
| LAMC1 | RILPL1 | 0.779074 | 4 | 0 | 4 |
| LAMC1 | COL4A2 | 0.771192 | 13 | 0 | 11 |
| LAMC1 | RAB34 | 0.769958 | 3 | 0 | 3 |
| LAMC1 | FBN1 | 0.768713 | 11 | 0 | 9 |
| LAMC1 | LAMA4 | 0.766818 | 12 | 0 | 12 |
| LAMC1 | COL12A1 | 0.752573 | 9 | 0 | 9 |
| LAMC1 | EFEMP2 | 0.751789 | 12 | 0 | 11 |
| LAMC1 | CLMP | 0.751503 | 6 | 0 | 6 |
| LAMC1 | LAMB1 | 0.750165 | 13 | 0 | 13 |
| LAMC1 | RHOBTB1 | 0.749566 | 13 | 0 | 13 |
| LAMC1 | TMEM263 | 0.749526 | 7 | 0 | 7 |
| LAMC1 | TTC7B | 0.748325 | 7 | 0 | 7 |
| LAMC1 | CLIC4 | 0.745521 | 13 | 0 | 11 |
| LAMC1 | LTBP1 | 0.744042 | 12 | 0 | 11 |
| LAMC1 | RHOQ | 0.743372 | 10 | 0 | 10 |
| LAMC1 | LGALS1 | 0.739928 | 12 | 0 | 11 |
For details and further investigation, click here
