| Full name: DENN domain containing 5B | Alias Symbol: MGC24039 | ||
| Type: protein-coding gene | Cytoband: 12p11.21 | ||
| Entrez ID: 160518 | HGNC ID: HGNC:28338 | Ensembl Gene: ENSG00000170456 | OMIM ID: 617279 |
| Drug and gene relationship at DGIdb | |||
Expression of DENND5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DENND5B | 160518 | 228551_at | -0.1133 | 0.8602 | |
| GSE20347 | DENND5B | 160518 | 215058_at | 0.0719 | 0.2476 | |
| GSE23400 | DENND5B | 160518 | 215058_at | -0.0038 | 0.8293 | |
| GSE26886 | DENND5B | 160518 | 238917_s_at | 0.7151 | 0.0000 | |
| GSE29001 | DENND5B | 160518 | 215058_at | -0.0729 | 0.5885 | |
| GSE38129 | DENND5B | 160518 | 215058_at | -0.1545 | 0.2662 | |
| GSE45670 | DENND5B | 160518 | 228551_at | -0.8073 | 0.0227 | |
| GSE53622 | DENND5B | 160518 | 46421 | -0.0663 | 0.7075 | |
| GSE53624 | DENND5B | 160518 | 46421 | 0.5190 | 0.0000 | |
| GSE63941 | DENND5B | 160518 | 238917_s_at | -0.3797 | 0.5332 | |
| GSE77861 | DENND5B | 160518 | 236415_at | -0.1007 | 0.4804 | |
| GSE97050 | DENND5B | 160518 | A_23_P379746 | -0.2905 | 0.3207 | |
| SRP007169 | DENND5B | 160518 | RNAseq | 2.2395 | 0.0087 | |
| SRP008496 | DENND5B | 160518 | RNAseq | 2.2004 | 0.0003 | |
| SRP064894 | DENND5B | 160518 | RNAseq | 0.4726 | 0.0349 | |
| SRP133303 | DENND5B | 160518 | RNAseq | 0.1731 | 0.1943 | |
| SRP159526 | DENND5B | 160518 | RNAseq | 0.6893 | 0.0413 | |
| SRP193095 | DENND5B | 160518 | RNAseq | 0.0306 | 0.9109 | |
| SRP219564 | DENND5B | 160518 | RNAseq | 0.2352 | 0.6117 | |
| TCGA | DENND5B | 160518 | RNAseq | -0.6085 | 0.0003 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DENND5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DENND5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DENND5B | 160518 | 10 | 2 | 18 | |
| GSE20123 | DENND5B | 160518 | 10 | 2 | 18 | |
| GSE43470 | DENND5B | 160518 | 8 | 4 | 31 | |
| GSE46452 | DENND5B | 160518 | 10 | 1 | 48 | |
| GSE47630 | DENND5B | 160518 | 12 | 1 | 27 | |
| GSE54993 | DENND5B | 160518 | 0 | 9 | 61 | |
| GSE54994 | DENND5B | 160518 | 8 | 2 | 43 | |
| GSE60625 | DENND5B | 160518 | 0 | 1 | 10 | |
| GSE74703 | DENND5B | 160518 | 7 | 3 | 26 | |
| GSE74704 | DENND5B | 160518 | 6 | 0 | 14 | |
| TCGA | DENND5B | 160518 | 42 | 5 | 49 |
Total number of gains: 113; Total number of losses: 30; Total Number of normals: 345.
Somatic mutations of DENND5B:
Generating mutation plots.
Highly correlated genes for DENND5B:
Showing top 20/821 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DENND5B | FAM168A | 0.753091 | 3 | 0 | 3 |
| DENND5B | SLC13A2 | 0.740541 | 3 | 0 | 3 |
| DENND5B | ZNF467 | 0.736138 | 3 | 0 | 3 |
| DENND5B | CDC42EP4 | 0.736129 | 3 | 0 | 3 |
| DENND5B | EHD1 | 0.727431 | 3 | 0 | 3 |
| DENND5B | ELMOD3 | 0.726827 | 3 | 0 | 3 |
| DENND5B | JPH3 | 0.719666 | 3 | 0 | 3 |
| DENND5B | SETBP1 | 0.713763 | 4 | 0 | 4 |
| DENND5B | CIC | 0.704827 | 3 | 0 | 3 |
| DENND5B | SLC2A4RG | 0.696675 | 3 | 0 | 3 |
| DENND5B | SLC41A2 | 0.696447 | 4 | 0 | 4 |
| DENND5B | MCAM | 0.690183 | 7 | 0 | 6 |
| DENND5B | DOCK11 | 0.688402 | 4 | 0 | 4 |
| DENND5B | TLN2 | 0.687844 | 5 | 0 | 4 |
| DENND5B | BRAP | 0.68729 | 3 | 0 | 3 |
| DENND5B | MYEF2 | 0.685583 | 3 | 0 | 3 |
| DENND5B | NME5 | 0.684479 | 5 | 0 | 4 |
| DENND5B | ASPA | 0.684469 | 5 | 0 | 3 |
| DENND5B | FAM124A | 0.684429 | 4 | 0 | 4 |
| DENND5B | MXD3 | 0.684052 | 3 | 0 | 3 |
For details and further investigation, click here
