| Full name: talin 2 | Alias Symbol: KIAA0320|ILWEQ | ||
| Type: protein-coding gene | Cytoband: 15q22.2 | ||
| Entrez ID: 83660 | HGNC ID: HGNC:15447 | Ensembl Gene: ENSG00000171914 | OMIM ID: 607349 |
| Drug and gene relationship at DGIdb | |||
TLN2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04611 | Platelet activation |
Expression of TLN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLN2 | 83660 | 212701_at | 0.1231 | 0.8329 | |
| GSE20347 | TLN2 | 83660 | 212703_at | 0.2377 | 0.0014 | |
| GSE23400 | TLN2 | 83660 | 212701_at | -0.1052 | 0.0374 | |
| GSE26886 | TLN2 | 83660 | 212703_at | 1.4552 | 0.0000 | |
| GSE29001 | TLN2 | 83660 | 212701_at | 0.1017 | 0.6604 | |
| GSE38129 | TLN2 | 83660 | 212701_at | -0.2695 | 0.0515 | |
| GSE45670 | TLN2 | 83660 | 212703_at | 0.1728 | 0.3745 | |
| GSE53622 | TLN2 | 83660 | 33835 | 0.3398 | 0.0001 | |
| GSE53624 | TLN2 | 83660 | 33835 | 0.1518 | 0.0672 | |
| GSE63941 | TLN2 | 83660 | 212701_at | -0.4437 | 0.5340 | |
| GSE77861 | TLN2 | 83660 | 212703_at | 0.2366 | 0.0909 | |
| GSE97050 | TLN2 | 83660 | A_33_P3264815 | -0.3917 | 0.1440 | |
| SRP007169 | TLN2 | 83660 | RNAseq | 3.9098 | 0.0000 | |
| SRP008496 | TLN2 | 83660 | RNAseq | 3.4009 | 0.0000 | |
| SRP064894 | TLN2 | 83660 | RNAseq | 0.9860 | 0.0020 | |
| SRP133303 | TLN2 | 83660 | RNAseq | 0.6997 | 0.0129 | |
| SRP159526 | TLN2 | 83660 | RNAseq | 1.0283 | 0.0005 | |
| SRP193095 | TLN2 | 83660 | RNAseq | 0.2278 | 0.5655 | |
| SRP219564 | TLN2 | 83660 | RNAseq | 0.3206 | 0.3610 | |
| TCGA | TLN2 | 83660 | RNAseq | -0.3492 | 0.0003 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by TLN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLN2 | 83660 | 8 | 2 | 20 | |
| GSE20123 | TLN2 | 83660 | 8 | 2 | 20 | |
| GSE43470 | TLN2 | 83660 | 4 | 6 | 33 | |
| GSE46452 | TLN2 | 83660 | 3 | 7 | 49 | |
| GSE47630 | TLN2 | 83660 | 8 | 10 | 22 | |
| GSE54993 | TLN2 | 83660 | 5 | 6 | 59 | |
| GSE54994 | TLN2 | 83660 | 6 | 8 | 39 | |
| GSE60625 | TLN2 | 83660 | 4 | 0 | 7 | |
| GSE74703 | TLN2 | 83660 | 4 | 3 | 29 | |
| GSE74704 | TLN2 | 83660 | 4 | 3 | 13 | |
| TCGA | TLN2 | 83660 | 11 | 16 | 69 |
Total number of gains: 65; Total number of losses: 63; Total Number of normals: 360.
Somatic mutations of TLN2:
Generating mutation plots.
Highly correlated genes for TLN2:
Showing top 20/912 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLN2 | AKAP8 | 0.802239 | 3 | 0 | 3 |
| TLN2 | DNPEP | 0.784371 | 3 | 0 | 3 |
| TLN2 | LNP1 | 0.773367 | 3 | 0 | 3 |
| TLN2 | ABCA6 | 0.767018 | 3 | 0 | 3 |
| TLN2 | ECSIT | 0.765757 | 4 | 0 | 4 |
| TLN2 | HMCN1 | 0.759488 | 3 | 0 | 3 |
| TLN2 | CFL2 | 0.757038 | 3 | 0 | 3 |
| TLN2 | PPP1R35 | 0.740832 | 3 | 0 | 3 |
| TLN2 | STAT5B | 0.738535 | 3 | 0 | 3 |
| TLN2 | KDM6B | 0.737137 | 3 | 0 | 3 |
| TLN2 | RPL19 | 0.736619 | 3 | 0 | 3 |
| TLN2 | TUB | 0.734994 | 3 | 0 | 3 |
| TLN2 | AKAP12 | 0.732543 | 3 | 0 | 3 |
| TLN2 | VAMP2 | 0.732534 | 3 | 0 | 3 |
| TLN2 | CCDC124 | 0.732407 | 3 | 0 | 3 |
| TLN2 | FBN1 | 0.73152 | 3 | 0 | 3 |
| TLN2 | NACC1 | 0.730855 | 3 | 0 | 3 |
| TLN2 | SORBS3 | 0.728108 | 5 | 0 | 5 |
| TLN2 | TRPC1 | 0.727953 | 4 | 0 | 3 |
| TLN2 | GAS2L1 | 0.726434 | 3 | 0 | 3 |
For details and further investigation, click here
