| Full name: disrupted in renal carcinoma 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q32.2 | ||
| Entrez ID: 116093 | HGNC ID: HGNC:15760 | Ensembl Gene: ENSG00000174325 | OMIM ID: 606423 |
| Drug and gene relationship at DGIdb | |||
Expression of DIRC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIRC1 | 116093 | 1552674_at | -0.0246 | 0.9381 | |
| GSE26886 | DIRC1 | 116093 | 1552674_at | 0.0532 | 0.4938 | |
| GSE45670 | DIRC1 | 116093 | 1552674_at | 0.1803 | 0.0045 | |
| GSE53622 | DIRC1 | 116093 | 40548 | -0.2343 | 0.0020 | |
| GSE53624 | DIRC1 | 116093 | 40548 | -0.7128 | 0.0000 | |
| GSE63941 | DIRC1 | 116093 | 1552674_at | 0.0498 | 0.6874 | |
| GSE77861 | DIRC1 | 116093 | 1552674_at | -0.0083 | 0.9363 | |
| GSE97050 | DIRC1 | 116093 | A_23_P131139 | 0.0763 | 0.6965 | |
| SRP133303 | DIRC1 | 116093 | RNAseq | 0.4469 | 0.0006 | |
| SRP193095 | DIRC1 | 116093 | RNAseq | 0.4718 | 0.0065 | |
| TCGA | DIRC1 | 116093 | RNAseq | 3.6954 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DIRC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIRC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIRC1 | 116093 | 8 | 2 | 20 | |
| GSE20123 | DIRC1 | 116093 | 8 | 2 | 20 | |
| GSE43470 | DIRC1 | 116093 | 3 | 1 | 39 | |
| GSE46452 | DIRC1 | 116093 | 1 | 4 | 54 | |
| GSE47630 | DIRC1 | 116093 | 4 | 5 | 31 | |
| GSE54993 | DIRC1 | 116093 | 0 | 5 | 65 | |
| GSE54994 | DIRC1 | 116093 | 12 | 6 | 35 | |
| GSE60625 | DIRC1 | 116093 | 0 | 3 | 8 | |
| GSE74703 | DIRC1 | 116093 | 2 | 1 | 33 | |
| GSE74704 | DIRC1 | 116093 | 3 | 2 | 15 | |
| TCGA | DIRC1 | 116093 | 24 | 7 | 65 |
Total number of gains: 65; Total number of losses: 38; Total Number of normals: 385.
Somatic mutations of DIRC1:
Generating mutation plots.
Highly correlated genes for DIRC1:
Showing top 20/92 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIRC1 | KRT71 | 0.790923 | 3 | 0 | 3 |
| DIRC1 | KRTAP10-10 | 0.721877 | 3 | 0 | 3 |
| DIRC1 | AMZ1 | 0.721426 | 3 | 0 | 3 |
| DIRC1 | SLC32A1 | 0.719802 | 3 | 0 | 3 |
| DIRC1 | LACTBL1 | 0.712143 | 3 | 0 | 3 |
| DIRC1 | CNR1 | 0.698526 | 3 | 0 | 3 |
| DIRC1 | POU3F4 | 0.698331 | 3 | 0 | 3 |
| DIRC1 | PXMP2 | 0.691107 | 3 | 0 | 3 |
| DIRC1 | JPH3 | 0.689285 | 3 | 0 | 3 |
| DIRC1 | SERPINA12 | 0.680307 | 3 | 0 | 3 |
| DIRC1 | WFIKKN1 | 0.673564 | 3 | 0 | 3 |
| DIRC1 | LDB1 | 0.671243 | 3 | 0 | 3 |
| DIRC1 | XG | 0.66869 | 3 | 0 | 3 |
| DIRC1 | MIER2 | 0.666355 | 3 | 0 | 3 |
| DIRC1 | RAB36 | 0.660126 | 3 | 0 | 3 |
| DIRC1 | SRRM2-AS1 | 0.656694 | 4 | 0 | 4 |
| DIRC1 | FN3K | 0.650986 | 3 | 0 | 3 |
| DIRC1 | ACRBP | 0.650261 | 3 | 0 | 3 |
| DIRC1 | TPSD1 | 0.649366 | 3 | 0 | 3 |
| DIRC1 | SMPD1 | 0.649358 | 4 | 0 | 3 |
For details and further investigation, click here
