| Full name: LIM domain binding 1 | Alias Symbol: NLI|CLIM2 | ||
| Type: protein-coding gene | Cytoband: 10q24.32 | ||
| Entrez ID: 8861 | HGNC ID: HGNC:6532 | Ensembl Gene: ENSG00000198728 | OMIM ID: 603451 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LDB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LDB1 | 8861 | 35160_at | 0.6277 | 0.1379 | |
| GSE20347 | LDB1 | 8861 | 35160_at | 0.1936 | 0.0111 | |
| GSE23400 | LDB1 | 8861 | 203451_at | 0.2946 | 0.0000 | |
| GSE26886 | LDB1 | 8861 | 35160_at | 0.3101 | 0.0017 | |
| GSE29001 | LDB1 | 8861 | 35160_at | 0.2297 | 0.1811 | |
| GSE38129 | LDB1 | 8861 | 35160_at | 0.3140 | 0.0001 | |
| GSE45670 | LDB1 | 8861 | 35160_at | 0.5418 | 0.0000 | |
| GSE53622 | LDB1 | 8861 | 130344 | 0.1545 | 0.0275 | |
| GSE53624 | LDB1 | 8861 | 130344 | 0.2644 | 0.0000 | |
| GSE63941 | LDB1 | 8861 | 35160_at | -0.3015 | 0.2860 | |
| GSE77861 | LDB1 | 8861 | 203451_at | 0.3524 | 0.2425 | |
| GSE97050 | LDB1 | 8861 | A_23_P97892 | -0.0349 | 0.9022 | |
| SRP007169 | LDB1 | 8861 | RNAseq | -0.1197 | 0.7235 | |
| SRP008496 | LDB1 | 8861 | RNAseq | -0.1375 | 0.4764 | |
| SRP064894 | LDB1 | 8861 | RNAseq | 0.0449 | 0.7267 | |
| SRP133303 | LDB1 | 8861 | RNAseq | -0.1003 | 0.4201 | |
| SRP159526 | LDB1 | 8861 | RNAseq | -0.1031 | 0.5989 | |
| SRP193095 | LDB1 | 8861 | RNAseq | 0.2765 | 0.0310 | |
| SRP219564 | LDB1 | 8861 | RNAseq | -0.3623 | 0.1405 | |
| TCGA | LDB1 | 8861 | RNAseq | 0.0346 | 0.4549 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LDB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LDB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LDB1 | 8861 | 2 | 9 | 19 | |
| GSE20123 | LDB1 | 8861 | 2 | 8 | 20 | |
| GSE43470 | LDB1 | 8861 | 0 | 8 | 35 | |
| GSE46452 | LDB1 | 8861 | 0 | 11 | 48 | |
| GSE47630 | LDB1 | 8861 | 2 | 14 | 24 | |
| GSE54993 | LDB1 | 8861 | 8 | 0 | 62 | |
| GSE54994 | LDB1 | 8861 | 1 | 12 | 40 | |
| GSE60625 | LDB1 | 8861 | 0 | 0 | 11 | |
| GSE74703 | LDB1 | 8861 | 0 | 5 | 31 | |
| GSE74704 | LDB1 | 8861 | 1 | 4 | 15 | |
| TCGA | LDB1 | 8861 | 5 | 29 | 62 |
Total number of gains: 21; Total number of losses: 100; Total Number of normals: 367.
Somatic mutations of LDB1:
Generating mutation plots.
Highly correlated genes for LDB1:
Showing top 20/848 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LDB1 | SLC43A2 | 0.804731 | 3 | 0 | 3 |
| LDB1 | TMEM63B | 0.795128 | 4 | 0 | 4 |
| LDB1 | UTP23 | 0.772271 | 3 | 0 | 3 |
| LDB1 | EIF3G | 0.760241 | 3 | 0 | 3 |
| LDB1 | INPP5E | 0.747619 | 3 | 0 | 3 |
| LDB1 | MATN4 | 0.736643 | 3 | 0 | 3 |
| LDB1 | LINC00328 | 0.734269 | 3 | 0 | 3 |
| LDB1 | SP3 | 0.733867 | 3 | 0 | 3 |
| LDB1 | WDR4 | 0.732878 | 4 | 0 | 4 |
| LDB1 | TNFRSF4 | 0.731195 | 3 | 0 | 3 |
| LDB1 | JOSD2 | 0.731175 | 3 | 0 | 3 |
| LDB1 | KDM6B | 0.729039 | 5 | 0 | 5 |
| LDB1 | CAMKK1 | 0.724212 | 5 | 0 | 5 |
| LDB1 | DPP9 | 0.723459 | 4 | 0 | 3 |
| LDB1 | AP2A1 | 0.717296 | 3 | 0 | 3 |
| LDB1 | FOXP4 | 0.712094 | 4 | 0 | 3 |
| LDB1 | STX1A | 0.709308 | 5 | 0 | 5 |
| LDB1 | RTN4R | 0.705578 | 4 | 0 | 3 |
| LDB1 | EP300 | 0.705261 | 3 | 0 | 3 |
| LDB1 | CHCHD7 | 0.703361 | 4 | 0 | 4 |
For details and further investigation, click here
