| Full name: cannabinoid receptor 1 | Alias Symbol: CB1K5|CB-R|CB1|CANN6|CB1A | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 1268 | HGNC ID: HGNC:2159 | Ensembl Gene: ENSG00000118432 | OMIM ID: 114610 |
| Drug and gene relationship at DGIdb | |||
CNR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04723 | Retrograde endocannabinoid signaling |
Expression of CNR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNR1 | 1268 | 207940_x_at | -0.0865 | 0.7967 | |
| GSE20347 | CNR1 | 1268 | 207940_x_at | -0.0884 | 0.3601 | |
| GSE23400 | CNR1 | 1268 | 207940_x_at | -0.1440 | 0.0001 | |
| GSE26886 | CNR1 | 1268 | 207940_x_at | -0.0649 | 0.6429 | |
| GSE29001 | CNR1 | 1268 | 207940_x_at | -0.3219 | 0.0326 | |
| GSE38129 | CNR1 | 1268 | 207940_x_at | -0.1220 | 0.2586 | |
| GSE45670 | CNR1 | 1268 | 207940_x_at | -0.1729 | 0.0217 | |
| GSE53622 | CNR1 | 1268 | 93220 | -1.6266 | 0.0000 | |
| GSE53624 | CNR1 | 1268 | 93220 | -1.3844 | 0.0000 | |
| GSE63941 | CNR1 | 1268 | 207940_x_at | -0.0135 | 0.9536 | |
| GSE77861 | CNR1 | 1268 | 207940_x_at | -0.1717 | 0.1445 | |
| GSE97050 | CNR1 | 1268 | A_23_P214208 | -0.3147 | 0.2581 | |
| SRP064894 | CNR1 | 1268 | RNAseq | -0.2953 | 0.6031 | |
| SRP133303 | CNR1 | 1268 | RNAseq | -1.0182 | 0.0163 | |
| SRP159526 | CNR1 | 1268 | RNAseq | -0.6390 | 0.3385 | |
| SRP219564 | CNR1 | 1268 | RNAseq | -1.1750 | 0.1732 | |
| TCGA | CNR1 | 1268 | RNAseq | -1.4635 | 0.0029 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by CNR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNR1 | 1268 | 1 | 4 | 25 | |
| GSE20123 | CNR1 | 1268 | 1 | 3 | 26 | |
| GSE43470 | CNR1 | 1268 | 3 | 1 | 39 | |
| GSE46452 | CNR1 | 1268 | 2 | 11 | 46 | |
| GSE47630 | CNR1 | 1268 | 8 | 6 | 26 | |
| GSE54993 | CNR1 | 1268 | 3 | 2 | 65 | |
| GSE54994 | CNR1 | 1268 | 8 | 8 | 37 | |
| GSE60625 | CNR1 | 1268 | 0 | 1 | 10 | |
| GSE74703 | CNR1 | 1268 | 3 | 1 | 32 | |
| GSE74704 | CNR1 | 1268 | 0 | 2 | 18 | |
| TCGA | CNR1 | 1268 | 5 | 21 | 70 |
Total number of gains: 34; Total number of losses: 60; Total Number of normals: 394.
Somatic mutations of CNR1:
Generating mutation plots.
Highly correlated genes for CNR1:
Showing top 20/929 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNR1 | RANBP10 | 0.780407 | 3 | 0 | 3 |
| CNR1 | MTIF3 | 0.772114 | 3 | 0 | 3 |
| CNR1 | HOXB3 | 0.757787 | 3 | 0 | 3 |
| CNR1 | ECSCR | 0.737347 | 3 | 0 | 3 |
| CNR1 | MAP1LC3A | 0.733401 | 3 | 0 | 3 |
| CNR1 | FAM172A | 0.730318 | 4 | 0 | 4 |
| CNR1 | ADAMTS9 | 0.729675 | 3 | 0 | 3 |
| CNR1 | FBXO42 | 0.725529 | 3 | 0 | 3 |
| CNR1 | HEYL | 0.722592 | 5 | 0 | 5 |
| CNR1 | ITGB3 | 0.714967 | 5 | 0 | 5 |
| CNR1 | POLH | 0.712401 | 3 | 0 | 3 |
| CNR1 | ESYT2 | 0.70995 | 3 | 0 | 3 |
| CNR1 | RNF103 | 0.708818 | 3 | 0 | 3 |
| CNR1 | DNAH1 | 0.708071 | 4 | 0 | 4 |
| CNR1 | ADH1A | 0.703399 | 3 | 0 | 3 |
| CNR1 | OPHN1 | 0.699613 | 5 | 0 | 4 |
| CNR1 | DIRC1 | 0.698526 | 3 | 0 | 3 |
| CNR1 | CYP21A2 | 0.69512 | 3 | 0 | 3 |
| CNR1 | DNASE1L2 | 0.691399 | 3 | 0 | 3 |
| CNR1 | MTUS1 | 0.68935 | 3 | 0 | 3 |
For details and further investigation, click here
