| Full name: peroxisomal membrane protein 2 | Alias Symbol: PMP22 | ||
| Type: protein-coding gene | Cytoband: 12q24.33 | ||
| Entrez ID: 5827 | HGNC ID: HGNC:9716 | Ensembl Gene: ENSG00000176894 | OMIM ID: 617399 |
| Drug and gene relationship at DGIdb | |||
Expression of PXMP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PXMP2 | 5827 | 219076_s_at | 0.2641 | 0.5509 | |
| GSE20347 | PXMP2 | 5827 | 219076_s_at | 0.0642 | 0.7656 | |
| GSE23400 | PXMP2 | 5827 | 219076_s_at | 0.0709 | 0.1695 | |
| GSE26886 | PXMP2 | 5827 | 219076_s_at | 0.3818 | 0.0600 | |
| GSE29001 | PXMP2 | 5827 | 219076_s_at | 0.3750 | 0.2763 | |
| GSE38129 | PXMP2 | 5827 | 219076_s_at | -0.0425 | 0.8291 | |
| GSE45670 | PXMP2 | 5827 | 219076_s_at | 0.0081 | 0.9701 | |
| GSE53622 | PXMP2 | 5827 | 3305 | -1.6154 | 0.0000 | |
| GSE53624 | PXMP2 | 5827 | 3305 | -2.2629 | 0.0000 | |
| GSE63941 | PXMP2 | 5827 | 219076_s_at | 0.5646 | 0.2582 | |
| GSE77861 | PXMP2 | 5827 | 219076_s_at | -0.1575 | 0.5617 | |
| GSE97050 | PXMP2 | 5827 | A_23_P124122 | 0.1757 | 0.5443 | |
| SRP007169 | PXMP2 | 5827 | RNAseq | 0.5317 | 0.3703 | |
| SRP008496 | PXMP2 | 5827 | RNAseq | -0.0787 | 0.8561 | |
| SRP064894 | PXMP2 | 5827 | RNAseq | 0.7132 | 0.0662 | |
| SRP133303 | PXMP2 | 5827 | RNAseq | -0.0616 | 0.6805 | |
| SRP159526 | PXMP2 | 5827 | RNAseq | 0.4058 | 0.1888 | |
| SRP193095 | PXMP2 | 5827 | RNAseq | -0.6046 | 0.0068 | |
| SRP219564 | PXMP2 | 5827 | RNAseq | -0.0305 | 0.9335 | |
| TCGA | PXMP2 | 5827 | RNAseq | -0.6816 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PXMP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PXMP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PXMP2 | 5827 | 4 | 5 | 21 | |
| GSE20123 | PXMP2 | 5827 | 4 | 5 | 21 | |
| GSE43470 | PXMP2 | 5827 | 3 | 3 | 37 | |
| GSE46452 | PXMP2 | 5827 | 8 | 3 | 48 | |
| GSE47630 | PXMP2 | 5827 | 9 | 3 | 28 | |
| GSE54993 | PXMP2 | 5827 | 0 | 6 | 64 | |
| GSE54994 | PXMP2 | 5827 | 4 | 8 | 41 | |
| GSE60625 | PXMP2 | 5827 | 1 | 0 | 10 | |
| GSE74703 | PXMP2 | 5827 | 2 | 3 | 31 | |
| GSE74704 | PXMP2 | 5827 | 2 | 3 | 15 | |
| TCGA | PXMP2 | 5827 | 21 | 15 | 60 |
Total number of gains: 58; Total number of losses: 54; Total Number of normals: 376.
Somatic mutations of PXMP2:
Generating mutation plots.
Highly correlated genes for PXMP2:
Showing top 20/239 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PXMP2 | BAG4 | 0.787177 | 3 | 0 | 3 |
| PXMP2 | CYP27C1 | 0.78602 | 3 | 0 | 3 |
| PXMP2 | PPP6R3 | 0.774155 | 3 | 0 | 3 |
| PXMP2 | LSM1 | 0.767124 | 3 | 0 | 3 |
| PXMP2 | MOB3C | 0.766451 | 4 | 0 | 4 |
| PXMP2 | CLIP1 | 0.755376 | 3 | 0 | 3 |
| PXMP2 | KCNK6 | 0.750366 | 3 | 0 | 3 |
| PXMP2 | EZR | 0.74573 | 3 | 0 | 3 |
| PXMP2 | BRDT | 0.742812 | 3 | 0 | 3 |
| PXMP2 | ZDHHC5 | 0.728823 | 3 | 0 | 3 |
| PXMP2 | KRTAP19-7 | 0.727725 | 3 | 0 | 3 |
| PXMP2 | NFKB1 | 0.726742 | 3 | 0 | 3 |
| PXMP2 | SRRM1 | 0.7259 | 3 | 0 | 3 |
| PXMP2 | ATXN1L | 0.720117 | 3 | 0 | 3 |
| PXMP2 | ASPG | 0.717772 | 3 | 0 | 3 |
| PXMP2 | DDI2 | 0.717476 | 3 | 0 | 3 |
| PXMP2 | KLF4 | 0.711703 | 3 | 0 | 3 |
| PXMP2 | RER1 | 0.709909 | 3 | 0 | 3 |
| PXMP2 | RAB11A | 0.70798 | 3 | 0 | 3 |
| PXMP2 | NOTCH2 | 0.704833 | 3 | 0 | 3 |
For details and further investigation, click here
