| Full name: DIS3 like exosome 3'-5' exoribonuclease | Alias Symbol: MGC4562|FLJ38088|KIAA1955|DIS3L1 | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 115752 | HGNC ID: HGNC:28698 | Ensembl Gene: ENSG00000166938 | OMIM ID: 614183 |
| Drug and gene relationship at DGIdb | |||
Expression of DIS3L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DIS3L | 115752 | 235005_at | -0.3969 | 0.5455 | |
| GSE26886 | DIS3L | 115752 | 235005_at | -0.2417 | 0.3609 | |
| GSE45670 | DIS3L | 115752 | 235005_at | -0.3675 | 0.0232 | |
| GSE53622 | DIS3L | 115752 | 33015 | 0.0062 | 0.9426 | |
| GSE53624 | DIS3L | 115752 | 33015 | -0.1881 | 0.0334 | |
| GSE63941 | DIS3L | 115752 | 235005_at | 0.3444 | 0.5476 | |
| GSE77861 | DIS3L | 115752 | 235005_at | 0.2387 | 0.3029 | |
| GSE97050 | DIS3L | 115752 | A_23_P65741 | -0.1510 | 0.5800 | |
| SRP007169 | DIS3L | 115752 | RNAseq | 0.2206 | 0.5660 | |
| SRP008496 | DIS3L | 115752 | RNAseq | 0.3738 | 0.2313 | |
| SRP064894 | DIS3L | 115752 | RNAseq | -0.1797 | 0.2705 | |
| SRP133303 | DIS3L | 115752 | RNAseq | 0.1121 | 0.4260 | |
| SRP159526 | DIS3L | 115752 | RNAseq | -0.1858 | 0.5958 | |
| SRP193095 | DIS3L | 115752 | RNAseq | 0.2184 | 0.0491 | |
| SRP219564 | DIS3L | 115752 | RNAseq | 0.1453 | 0.7309 | |
| TCGA | DIS3L | 115752 | RNAseq | -0.0779 | 0.1668 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DIS3L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DIS3L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DIS3L | 115752 | 7 | 3 | 20 | |
| GSE20123 | DIS3L | 115752 | 7 | 3 | 20 | |
| GSE43470 | DIS3L | 115752 | 4 | 6 | 33 | |
| GSE46452 | DIS3L | 115752 | 3 | 7 | 49 | |
| GSE47630 | DIS3L | 115752 | 8 | 10 | 22 | |
| GSE54993 | DIS3L | 115752 | 5 | 6 | 59 | |
| GSE54994 | DIS3L | 115752 | 6 | 7 | 40 | |
| GSE60625 | DIS3L | 115752 | 4 | 0 | 7 | |
| GSE74703 | DIS3L | 115752 | 4 | 3 | 29 | |
| GSE74704 | DIS3L | 115752 | 3 | 3 | 14 | |
| TCGA | DIS3L | 115752 | 9 | 16 | 71 |
Total number of gains: 60; Total number of losses: 64; Total Number of normals: 364.
Somatic mutations of DIS3L:
Generating mutation plots.
Highly correlated genes for DIS3L:
Showing top 20/345 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DIS3L | CGRRF1 | 0.818027 | 3 | 0 | 3 |
| DIS3L | ZNF33A | 0.800992 | 3 | 0 | 3 |
| DIS3L | NAA25 | 0.767585 | 3 | 0 | 3 |
| DIS3L | IPO7 | 0.762522 | 3 | 0 | 3 |
| DIS3L | SARNP | 0.760812 | 3 | 0 | 3 |
| DIS3L | N4BP2L2 | 0.753228 | 3 | 0 | 3 |
| DIS3L | SNX18 | 0.752326 | 3 | 0 | 3 |
| DIS3L | TMEM181 | 0.749902 | 3 | 0 | 3 |
| DIS3L | RSBN1 | 0.749267 | 3 | 0 | 3 |
| DIS3L | SOS1 | 0.742651 | 3 | 0 | 3 |
| DIS3L | KPNA5 | 0.740479 | 3 | 0 | 3 |
| DIS3L | SNAPIN | 0.739314 | 3 | 0 | 3 |
| DIS3L | ARGLU1 | 0.737514 | 3 | 0 | 3 |
| DIS3L | BTRC | 0.737468 | 3 | 0 | 3 |
| DIS3L | CDIPT | 0.736359 | 3 | 0 | 3 |
| DIS3L | WASL | 0.735645 | 3 | 0 | 3 |
| DIS3L | XPO4 | 0.73366 | 4 | 0 | 4 |
| DIS3L | EIF3C | 0.733371 | 3 | 0 | 3 |
| DIS3L | KBTBD7 | 0.727567 | 3 | 0 | 3 |
| DIS3L | RPP30 | 0.726024 | 3 | 0 | 3 |
For details and further investigation, click here
