TMEM181

 

Full name: transmembrane protein 181 Alias Symbol: 
Type: protein-coding gene Cytoband: 6q25.3
Entrez ID: 57583 HGNC ID: HGNC:20958 Ensembl Gene: ENSG00000146433 OMIM ID: 613209
Drug and gene relationship at DGIdb

 

Expression of TMEM181:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TMEM181 57583 225127_at 0.2308 0.5762
GSE26886 TMEM181 57583 225127_at -0.1841 0.4719
GSE45670 TMEM181 57583 225127_at 0.2542 0.1231
GSE53622 TMEM181 57583 116368 0.1867 0.0487
GSE53624 TMEM181 57583 116368 0.2880 0.0026
GSE63941 TMEM181 57583 225127_at -1.4091 0.0026
GSE77861 TMEM181 57583 225127_at 0.6101 0.0662
GSE97050 TMEM181 57583 A_23_P331943 -0.0212 0.9472
SRP007169 TMEM181 57583 RNAseq 1.2764 0.0016
SRP008496 TMEM181 57583 RNAseq 1.1023 0.0000
SRP064894 TMEM181 57583 RNAseq 0.4104 0.0329
SRP133303 TMEM181 57583 RNAseq 0.3487 0.0227
SRP159526 TMEM181 57583 RNAseq 0.1623 0.4795
SRP193095 TMEM181 57583 RNAseq -0.2025 0.2333
SRP219564 TMEM181 57583 RNAseq 0.0080 0.9692
TCGA TMEM181 57583 RNAseq -0.2551 0.0000

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by TMEM181 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TMEM181:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TMEM181 57583 3 5 22
GSE20123 TMEM181 57583 3 4 23
GSE43470 TMEM181 57583 4 0 39
GSE46452 TMEM181 57583 3 10 46
GSE47630 TMEM181 57583 9 4 27
GSE54993 TMEM181 57583 3 2 65
GSE54994 TMEM181 57583 8 8 37
GSE60625 TMEM181 57583 0 1 10
GSE74703 TMEM181 57583 4 0 32
GSE74704 TMEM181 57583 1 2 17
TCGA TMEM181 57583 13 22 61

Total number of gains: 51; Total number of losses: 58; Total Number of normals: 379.  

 

Somatic mutations of TMEM181:

 

Generating mutation plots.

 

Highly correlated genes for TMEM181:

 

Showing top 20/609 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TMEM181PMS10.811606303
TMEM181PKD20.805402303
TMEM181ZNF8050.802038303
TMEM181LMLN0.800149303
TMEM181NEK70.794993303
TMEM181WWP10.788722404
TMEM181ZNF7910.785514404
TMEM181U2AF20.785062303
TMEM181GPR1070.784285303
TMEM181C19orf180.780984303
TMEM181SFSWAP0.778206303
TMEM181NOM10.777421303
TMEM181RBM12B0.770608303
TMEM181SSB0.765908404
TMEM181METTL80.758305303
TMEM181DDX590.757687303
TMEM181MKLN10.75734303
TMEM181ZNF1460.75722404
TMEM181GNA110.757172303
TMEM181CHIC10.755371303

For details and further investigation, click here