| Full name: eukaryotic translation initiation factor 3 subunit C | Alias Symbol: eIF3-p110|eIF3c | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 8663 | HGNC ID: HGNC:3279 | Ensembl Gene: ENSG00000184110 | OMIM ID: 603916 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF3C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF3C | 8663 | 236700_at | 0.7457 | 0.3358 | |
| GSE26886 | EIF3C | 8663 | 236700_at | -0.6171 | 0.0130 | |
| GSE45670 | EIF3C | 8663 | 236700_at | 0.8828 | 0.0019 | |
| GSE63941 | EIF3C | 8663 | 236700_at | 1.1889 | 0.0041 | |
| GSE77861 | EIF3C | 8663 | 236700_at | 0.1634 | 0.5939 | |
| GSE97050 | EIF3C | 8663 | A_33_P3421733 | 0.2951 | 0.2583 | |
| SRP007169 | EIF3C | 8663 | RNAseq | -0.0110 | 0.9761 | |
| SRP008496 | EIF3C | 8663 | RNAseq | 0.2444 | 0.7515 | |
| SRP064894 | EIF3C | 8663 | RNAseq | 0.0944 | 0.5887 | |
| SRP133303 | EIF3C | 8663 | RNAseq | 0.1845 | 0.3954 | |
| SRP159526 | EIF3C | 8663 | RNAseq | 0.0484 | 0.8435 | |
| SRP193095 | EIF3C | 8663 | RNAseq | -0.0763 | 0.5816 | |
| SRP219564 | EIF3C | 8663 | RNAseq | 0.1799 | 0.6315 | |
| TCGA | EIF3C | 8663 | RNAseq | 0.4274 | 0.0005 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EIF3C expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of EIF3C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF3C | 8663 | 5 | 5 | 20 | |
| GSE20123 | EIF3C | 8663 | 5 | 4 | 21 | |
| GSE43470 | EIF3C | 8663 | 4 | 3 | 36 | |
| GSE46452 | EIF3C | 8663 | 38 | 1 | 20 | |
| GSE47630 | EIF3C | 8663 | 11 | 7 | 22 | |
| GSE54993 | EIF3C | 8663 | 3 | 5 | 62 | |
| GSE54994 | EIF3C | 8663 | 4 | 9 | 40 | |
| GSE60625 | EIF3C | 8663 | 4 | 0 | 7 | |
| GSE74703 | EIF3C | 8663 | 4 | 2 | 30 | |
| GSE74704 | EIF3C | 8663 | 3 | 2 | 15 | |
| TCGA | EIF3C | 8663 | 20 | 12 | 64 |
Total number of gains: 101; Total number of losses: 50; Total Number of normals: 337.
Somatic mutations of EIF3C:
Generating mutation plots.
Highly correlated genes for EIF3C:
Showing top 20/298 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF3C | SNRPE | 0.799583 | 3 | 0 | 3 |
| EIF3C | ZNF136 | 0.795662 | 3 | 0 | 3 |
| EIF3C | PAK1IP1 | 0.791705 | 3 | 0 | 3 |
| EIF3C | NUCKS1 | 0.786333 | 3 | 0 | 3 |
| EIF3C | METTL14 | 0.772054 | 3 | 0 | 3 |
| EIF3C | NASP | 0.770249 | 3 | 0 | 3 |
| EIF3C | TAF11 | 0.770067 | 3 | 0 | 3 |
| EIF3C | LSG1 | 0.76973 | 3 | 0 | 3 |
| EIF3C | ZNF234 | 0.769192 | 3 | 0 | 3 |
| EIF3C | HNRNPR | 0.764316 | 3 | 0 | 3 |
| EIF3C | DLGAP4 | 0.763369 | 3 | 0 | 3 |
| EIF3C | RPP40 | 0.762208 | 3 | 0 | 3 |
| EIF3C | EIF1AX | 0.75936 | 3 | 0 | 3 |
| EIF3C | FCF1 | 0.75679 | 3 | 0 | 3 |
| EIF3C | PACSIN3 | 0.750145 | 3 | 0 | 3 |
| EIF3C | ZNF165 | 0.747972 | 3 | 0 | 3 |
| EIF3C | MRPL18 | 0.746947 | 3 | 0 | 3 |
| EIF3C | HNRNPA1 | 0.741291 | 3 | 0 | 3 |
| EIF3C | SPCS2 | 0.738629 | 3 | 0 | 3 |
| EIF3C | GOLPH3 | 0.736849 | 3 | 0 | 3 |
For details and further investigation, click here
