SOS1

 

Full name: SOS Ras/Rac guanine nucleotide exchange factor 1 Alias Symbol: HGF|GF1
Type: protein-coding gene Cytoband: 2p22.1
Entrez ID: 6654 HGNC ID: HGNC:11187 Ensembl Gene: ENSG00000115904 OMIM ID: 182530
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 20/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SOS1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04068FoxO signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04917Prolactin signaling pathway
hsa05034Alcoholism
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of SOS1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SOS1 6654 227426_at -0.1290 0.7725
GSE20347 SOS1 6654 212780_at -0.1750 0.3374
GSE23400 SOS1 6654 212777_at -0.2623 0.0000
GSE26886 SOS1 6654 212780_at 0.1743 0.4442
GSE29001 SOS1 6654 212780_at -0.0396 0.8835
GSE38129 SOS1 6654 212780_at -0.0192 0.9092
GSE45670 SOS1 6654 227426_at -0.1403 0.3849
GSE53622 SOS1 6654 38939 0.2260 0.0000
GSE53624 SOS1 6654 38939 -0.0018 0.9768
GSE63941 SOS1 6654 227426_at -0.4580 0.2069
GSE77861 SOS1 6654 227426_at -0.0138 0.9347
GSE97050 SOS1 6654 A_23_P343808 0.1628 0.5210
SRP007169 SOS1 6654 RNAseq -0.1468 0.6516
SRP008496 SOS1 6654 RNAseq -0.0110 0.9445
SRP064894 SOS1 6654 RNAseq -0.3036 0.1775
SRP133303 SOS1 6654 RNAseq 0.2015 0.1753
SRP159526 SOS1 6654 RNAseq -0.0607 0.6925
SRP193095 SOS1 6654 RNAseq -0.0508 0.4690
SRP219564 SOS1 6654 RNAseq -0.1314 0.6537
TCGA SOS1 6654 RNAseq -0.0949 0.0301

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SOS1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SOS1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SOS1 6654 11 1 18
GSE20123 SOS1 6654 9 1 20
GSE43470 SOS1 6654 3 0 40
GSE46452 SOS1 6654 1 4 54
GSE47630 SOS1 6654 7 0 33
GSE54993 SOS1 6654 0 5 65
GSE54994 SOS1 6654 10 0 43
GSE60625 SOS1 6654 0 3 8
GSE74703 SOS1 6654 3 0 33
GSE74704 SOS1 6654 9 1 10
TCGA SOS1 6654 35 2 59

Total number of gains: 88; Total number of losses: 17; Total Number of normals: 383.  

 

Somatic mutations of SOS1:

 

Generating mutation plots.

 

Highly correlated genes for SOS1:

 

Showing top 20/219 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SOS1SLC25A30.743734403
SOS1DIS3L0.742651303
SOS1YIPF40.735698303
SOS1POLI0.733207303
SOS1RHOU0.723427303
SOS1CDC260.718279303
SOS1COG50.717065303
SOS1PRPF38A0.709409303
SOS1AP3M10.704909303
SOS1MDH20.703751303
SOS1DENND1B0.703705303
SOS1FAF20.702869303
SOS1NEK70.700571303
SOS1TNRC6B0.699302403
SOS1NHLRC20.699102403
SOS1SON0.693626504
SOS1SNAPC30.685101303
SOS1UBQLN20.684673403
SOS1CCT80.681142303
SOS1HDAC60.680557303

For details and further investigation, click here