| Full name: importin 7 | Alias Symbol: Imp7 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 10527 | HGNC ID: HGNC:9852 | Ensembl Gene: ENSG00000205339 | OMIM ID: 605586 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of IPO7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IPO7 | 10527 | 200993_at | -0.3108 | 0.5549 | |
| GSE20347 | IPO7 | 10527 | 200992_at | 0.0243 | 0.8925 | |
| GSE23400 | IPO7 | 10527 | 200992_at | 0.6424 | 0.0000 | |
| GSE26886 | IPO7 | 10527 | 200992_at | 0.1313 | 0.6617 | |
| GSE29001 | IPO7 | 10527 | 200994_at | 0.2370 | 0.2332 | |
| GSE38129 | IPO7 | 10527 | 200992_at | 0.2226 | 0.0638 | |
| GSE45670 | IPO7 | 10527 | 200992_at | 0.1605 | 0.2627 | |
| GSE53622 | IPO7 | 10527 | 68215 | 0.0585 | 0.4333 | |
| GSE53624 | IPO7 | 10527 | 68215 | 0.0410 | 0.6440 | |
| GSE63941 | IPO7 | 10527 | 200992_at | 0.8057 | 0.0472 | |
| GSE77861 | IPO7 | 10527 | 200992_at | 0.3394 | 0.3673 | |
| GSE97050 | IPO7 | A_19_P00802141 | -0.0409 | 0.9022 | ||
| SRP007169 | IPO7 | 10527 | RNAseq | 1.3500 | 0.0012 | |
| SRP008496 | IPO7 | 10527 | RNAseq | 1.4294 | 0.0000 | |
| SRP064894 | IPO7 | 10527 | RNAseq | -0.1180 | 0.5632 | |
| SRP133303 | IPO7 | 10527 | RNAseq | 0.3464 | 0.0005 | |
| SRP159526 | IPO7 | 10527 | RNAseq | -0.3428 | 0.3818 | |
| SRP193095 | IPO7 | 10527 | RNAseq | 0.1531 | 0.1596 | |
| SRP219564 | IPO7 | 10527 | RNAseq | -0.2229 | 0.3604 | |
| TCGA | IPO7 | 10527 | RNAseq | 0.0077 | 0.8529 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by IPO7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IPO7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IPO7 | 10527 | 0 | 9 | 21 | |
| GSE20123 | IPO7 | 10527 | 0 | 9 | 21 | |
| GSE43470 | IPO7 | 10527 | 1 | 6 | 36 | |
| GSE46452 | IPO7 | 10527 | 7 | 5 | 47 | |
| GSE47630 | IPO7 | 10527 | 3 | 11 | 26 | |
| GSE54993 | IPO7 | 10527 | 3 | 1 | 66 | |
| GSE54994 | IPO7 | 10527 | 2 | 15 | 36 | |
| GSE60625 | IPO7 | 10527 | 0 | 0 | 11 | |
| GSE74703 | IPO7 | 10527 | 1 | 4 | 31 | |
| GSE74704 | IPO7 | 10527 | 0 | 7 | 13 | |
| TCGA | IPO7 | 10527 | 11 | 34 | 51 |
Total number of gains: 28; Total number of losses: 101; Total Number of normals: 359.
Somatic mutations of IPO7:
Generating mutation plots.
Highly correlated genes for IPO7:
Showing top 20/449 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IPO7 | GTF2A2 | 0.7709 | 3 | 0 | 3 |
| IPO7 | DIS3L | 0.762522 | 3 | 0 | 3 |
| IPO7 | DNMBP | 0.749915 | 3 | 0 | 3 |
| IPO7 | MTFMT | 0.741638 | 3 | 0 | 3 |
| IPO7 | TRAP1 | 0.735223 | 3 | 0 | 3 |
| IPO7 | KAT5 | 0.725876 | 3 | 0 | 3 |
| IPO7 | MEX3C | 0.72201 | 4 | 0 | 4 |
| IPO7 | CGRRF1 | 0.719078 | 3 | 0 | 3 |
| IPO7 | USP24 | 0.713568 | 3 | 0 | 3 |
| IPO7 | WDR20 | 0.70915 | 3 | 0 | 3 |
| IPO7 | CTTNBP2NL | 0.70914 | 3 | 0 | 3 |
| IPO7 | STXBP3 | 0.70893 | 3 | 0 | 3 |
| IPO7 | ZNF627 | 0.706971 | 3 | 0 | 3 |
| IPO7 | WDR47 | 0.702914 | 3 | 0 | 3 |
| IPO7 | ZNF689 | 0.695274 | 3 | 0 | 3 |
| IPO7 | CEP68 | 0.694928 | 3 | 0 | 3 |
| IPO7 | TSEN15 | 0.692554 | 3 | 0 | 3 |
| IPO7 | INSIG1 | 0.692439 | 3 | 0 | 3 |
| IPO7 | TRIB1 | 0.6847 | 3 | 0 | 3 |
| IPO7 | PRKD3 | 0.680668 | 3 | 0 | 3 |
For details and further investigation, click here
