| Full name: WASP like actin nucleation promoting factor | Alias Symbol: N-WASP|NWASP|WASPB | ||
| Type: protein-coding gene | Cytoband: 7q31.32 | ||
| Entrez ID: 8976 | HGNC ID: HGNC:12735 | Ensembl Gene: ENSG00000106299 | OMIM ID: 605056 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
WASL involved pathways:
Expression of WASL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WASL | 8976 | 224813_at | -0.2090 | 0.7206 | |
| GSE20347 | WASL | 8976 | 205809_s_at | -1.1321 | 0.0001 | |
| GSE23400 | WASL | 8976 | 205810_s_at | -0.4748 | 0.0000 | |
| GSE26886 | WASL | 8976 | 224813_at | -0.6162 | 0.0123 | |
| GSE29001 | WASL | 8976 | 205809_s_at | -0.6072 | 0.1309 | |
| GSE38129 | WASL | 8976 | 205809_s_at | -0.7282 | 0.0115 | |
| GSE45670 | WASL | 8976 | 224813_at | -0.1428 | 0.2962 | |
| GSE53622 | WASL | 8976 | 15399 | -0.4981 | 0.0000 | |
| GSE53624 | WASL | 8976 | 15399 | -0.4386 | 0.0000 | |
| GSE63941 | WASL | 8976 | 224813_at | -1.1024 | 0.0224 | |
| GSE77861 | WASL | 8976 | 224813_at | -0.2388 | 0.4060 | |
| GSE97050 | WASL | 8976 | A_33_P3405444 | -0.5319 | 0.1856 | |
| SRP007169 | WASL | 8976 | RNAseq | -1.0296 | 0.0143 | |
| SRP008496 | WASL | 8976 | RNAseq | -0.9924 | 0.0000 | |
| SRP064894 | WASL | 8976 | RNAseq | -0.6065 | 0.0038 | |
| SRP133303 | WASL | 8976 | RNAseq | -0.1109 | 0.4913 | |
| SRP159526 | WASL | 8976 | RNAseq | -0.7203 | 0.0155 | |
| SRP193095 | WASL | 8976 | RNAseq | -0.9823 | 0.0000 | |
| SRP219564 | WASL | 8976 | RNAseq | -0.9451 | 0.0225 | |
| TCGA | WASL | 8976 | RNAseq | -0.1264 | 0.0040 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by WASL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WASL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WASL | 8976 | 6 | 2 | 22 | |
| GSE20123 | WASL | 8976 | 7 | 2 | 21 | |
| GSE43470 | WASL | 8976 | 2 | 4 | 37 | |
| GSE46452 | WASL | 8976 | 8 | 1 | 50 | |
| GSE47630 | WASL | 8976 | 7 | 4 | 29 | |
| GSE54993 | WASL | 8976 | 3 | 5 | 62 | |
| GSE54994 | WASL | 8976 | 9 | 7 | 37 | |
| GSE60625 | WASL | 8976 | 0 | 0 | 11 | |
| GSE74703 | WASL | 8976 | 2 | 4 | 30 | |
| GSE74704 | WASL | 8976 | 5 | 2 | 13 | |
| TCGA | WASL | 8976 | 27 | 21 | 48 |
Total number of gains: 76; Total number of losses: 52; Total Number of normals: 360.
Somatic mutations of WASL:
Generating mutation plots.
Highly correlated genes for WASL:
Showing top 20/925 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WASL | IFT46 | 0.793234 | 3 | 0 | 3 |
| WASL | STUB1 | 0.759288 | 3 | 0 | 3 |
| WASL | TMX3 | 0.73865 | 3 | 0 | 3 |
| WASL | FBXW5 | 0.738624 | 3 | 0 | 3 |
| WASL | DIS3L | 0.735645 | 3 | 0 | 3 |
| WASL | ZNF570 | 0.723774 | 3 | 0 | 3 |
| WASL | PTAR1 | 0.714573 | 3 | 0 | 3 |
| WASL | NFAT5 | 0.712759 | 4 | 0 | 3 |
| WASL | N4BP1 | 0.703543 | 3 | 0 | 3 |
| WASL | ZNF44 | 0.698821 | 3 | 0 | 3 |
| WASL | WASF2 | 0.694956 | 4 | 0 | 4 |
| WASL | ANKRD13A | 0.694075 | 6 | 0 | 6 |
| WASL | C21orf91 | 0.690412 | 4 | 0 | 3 |
| WASL | ERP44 | 0.688322 | 4 | 0 | 4 |
| WASL | ARMC10 | 0.684752 | 3 | 0 | 3 |
| WASL | LUC7L2 | 0.684236 | 4 | 0 | 3 |
| WASL | ZNF212 | 0.681823 | 7 | 0 | 6 |
| WASL | TBC1D23 | 0.679567 | 3 | 0 | 3 |
| WASL | RNF185 | 0.67374 | 4 | 0 | 4 |
| WASL | SCARB2 | 0.673263 | 3 | 0 | 3 |
For details and further investigation, click here
