| Full name: discs large MAGUK scaffold protein 4 | Alias Symbol: PSD-95|PSD95|SAP90|SAP-90 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 1742 | HGNC ID: HGNC:2903 | Ensembl Gene: ENSG00000132535 | OMIM ID: 602887 |
| Drug and gene relationship at DGIdb | |||
DLG4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway | |
| hsa04724 | Glutamatergic synapse | |
| hsa05016 | Huntington's disease | |
| hsa05030 | Cocaine addiction |
Expression of DLG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DLG4 | 1742 | 210684_s_at | 0.0419 | 0.8823 | |
| GSE20347 | DLG4 | 1742 | 210684_s_at | -0.1355 | 0.1248 | |
| GSE23400 | DLG4 | 1742 | 204592_at | 0.0581 | 0.1287 | |
| GSE26886 | DLG4 | 1742 | 210684_s_at | 0.3453 | 0.0267 | |
| GSE29001 | DLG4 | 1742 | 204592_at | 0.0432 | 0.8903 | |
| GSE38129 | DLG4 | 1742 | 210684_s_at | -0.1087 | 0.2404 | |
| GSE45670 | DLG4 | 1742 | 210684_s_at | -0.0631 | 0.6366 | |
| GSE53622 | DLG4 | 1742 | 147958 | -0.1707 | 0.1313 | |
| GSE53624 | DLG4 | 1742 | 147958 | -0.0356 | 0.7016 | |
| GSE63941 | DLG4 | 1742 | 210684_s_at | 0.1036 | 0.6026 | |
| GSE77861 | DLG4 | 1742 | 210684_s_at | -0.0921 | 0.5033 | |
| GSE97050 | DLG4 | 1742 | A_23_P411102 | 0.0967 | 0.6385 | |
| SRP007169 | DLG4 | 1742 | RNAseq | 0.8320 | 0.2178 | |
| SRP064894 | DLG4 | 1742 | RNAseq | 0.3690 | 0.1348 | |
| SRP133303 | DLG4 | 1742 | RNAseq | -0.1770 | 0.3722 | |
| SRP159526 | DLG4 | 1742 | RNAseq | 0.3484 | 0.1982 | |
| SRP193095 | DLG4 | 1742 | RNAseq | 0.3592 | 0.0116 | |
| SRP219564 | DLG4 | 1742 | RNAseq | -0.1447 | 0.6823 | |
| TCGA | DLG4 | 1742 | RNAseq | -0.4039 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DLG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DLG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DLG4 | 1742 | 4 | 2 | 24 | |
| GSE20123 | DLG4 | 1742 | 4 | 3 | 23 | |
| GSE43470 | DLG4 | 1742 | 1 | 4 | 38 | |
| GSE46452 | DLG4 | 1742 | 34 | 1 | 24 | |
| GSE47630 | DLG4 | 1742 | 7 | 1 | 32 | |
| GSE54993 | DLG4 | 1742 | 4 | 3 | 63 | |
| GSE54994 | DLG4 | 1742 | 5 | 8 | 40 | |
| GSE60625 | DLG4 | 1742 | 4 | 0 | 7 | |
| GSE74703 | DLG4 | 1742 | 1 | 2 | 33 | |
| GSE74704 | DLG4 | 1742 | 2 | 1 | 17 | |
| TCGA | DLG4 | 1742 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of DLG4:
Generating mutation plots.
Highly correlated genes for DLG4:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DLG4 | HRH2 | 0.746956 | 3 | 0 | 3 |
| DLG4 | ELAVL3 | 0.728931 | 6 | 0 | 6 |
| DLG4 | ZNF574 | 0.708049 | 3 | 0 | 3 |
| DLG4 | CRIP3 | 0.698194 | 3 | 0 | 3 |
| DLG4 | CBS | 0.695908 | 3 | 0 | 3 |
| DLG4 | FAM99B | 0.69453 | 3 | 0 | 3 |
| DLG4 | SHBG | 0.688417 | 3 | 0 | 3 |
| DLG4 | C11orf97 | 0.688052 | 3 | 0 | 3 |
| DLG4 | SCUBE1 | 0.684011 | 5 | 0 | 4 |
| DLG4 | BHLHE23 | 0.683123 | 3 | 0 | 3 |
| DLG4 | LINC00608 | 0.675219 | 3 | 0 | 3 |
| DLG4 | FUT7 | 0.674664 | 8 | 0 | 8 |
| DLG4 | VCX2 | 0.67166 | 6 | 0 | 6 |
| DLG4 | AMN | 0.663267 | 6 | 0 | 6 |
| DLG4 | L3MBTL1 | 0.660156 | 7 | 0 | 5 |
| DLG4 | ZNF646 | 0.655529 | 6 | 0 | 5 |
| DLG4 | COL26A1 | 0.655004 | 3 | 0 | 3 |
| DLG4 | NRG1 | 0.654273 | 5 | 0 | 4 |
| DLG4 | PGC | 0.652008 | 3 | 0 | 3 |
| DLG4 | FAM181B | 0.651487 | 3 | 0 | 3 |
For details and further investigation, click here
