SHBG

 

Full name: sex hormone binding globulin Alias Symbol: ABP|TEBG|MGC126834|MGC138391
Type: protein-coding gene Cytoband: 17p13.1
Entrez ID: 6462 HGNC ID: HGNC:10839 Ensembl Gene: ENSG00000129214 OMIM ID: 182205
Drug and gene relationship at DGIdb

 

Expression of SHBG:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SHBG 6462 215689_s_at -0.0910 0.7896
GSE20347 SHBG 6462 215689_s_at -0.0371 0.7470
GSE23400 SHBG 6462 215689_s_at -0.2489 0.0000
GSE26886 SHBG 6462 215689_s_at -0.0145 0.9224
GSE29001 SHBG 6462 215689_s_at -0.2868 0.0886
GSE38129 SHBG 6462 215689_s_at -0.1130 0.1726
GSE45670 SHBG 6462 215689_s_at -0.0327 0.7931
GSE53622 SHBG 6462 52598 -0.8905 0.0000
GSE53624 SHBG 6462 52598 -0.3191 0.0000
GSE63941 SHBG 6462 215689_s_at 0.2289 0.0941
GSE77861 SHBG 6462 215689_s_at -0.0730 0.6622
TCGA SHBG 6462 RNAseq -0.0204 0.9754

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by SHBG expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of SHBG:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SHBG 6462 4 2 24
GSE20123 SHBG 6462 4 3 23
GSE43470 SHBG 6462 1 6 36
GSE46452 SHBG 6462 34 1 24
GSE47630 SHBG 6462 7 1 32
GSE54993 SHBG 6462 4 3 63
GSE54994 SHBG 6462 5 8 40
GSE60625 SHBG 6462 4 0 7
GSE74703 SHBG 6462 1 3 32
GSE74704 SHBG 6462 2 1 17
TCGA SHBG 6462 17 21 58

Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.  


 

Somatic mutations of SHBG:

 

Generating mutation plots.

 

Highly correlated genes for SHBG:

 

Showing top 20/1248 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SHBGDRD50.742596404
SHBGHHLA10.724272808
SHBGKLF150.717097404
SHBGRCVRN0.705133505
SHBGSLC28A20.70261404
SHBGNPHS20.69997605
SHBGHAND10.693591505
SHBGBTN1A10.689194505
SHBGDLG40.688417303
SHBGOVGP10.687638505
SHBGCD50.685311505
SHBGGJC20.679956504
SHBGMTAP0.678944505
SHBGGABRA50.67282404
SHBGCAMP0.672625404
SHBGIL1RL10.671485403
SHBGNANOS20.669811504
SHBGRNF390.668508303
SHBGFSCN30.66685504
SHBGADAM110.666121907

For details and further investigation, click here