| Full name: histamine receptor H2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q35.2 | ||
| Entrez ID: 3274 | HGNC ID: HGNC:5183 | Ensembl Gene: ENSG00000113749 | OMIM ID: 142703 |
| Drug and gene relationship at DGIdb | |||
HRH2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04971 | Gastric acid secretion |
Expression of HRH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HRH2 | 3274 | 220805_at | -0.0792 | 0.7871 | |
| GSE20347 | HRH2 | 3274 | 220805_at | -0.1323 | 0.1818 | |
| GSE23400 | HRH2 | 3274 | 220805_at | 0.0833 | 0.0373 | |
| GSE26886 | HRH2 | 3274 | 220805_at | 0.1341 | 0.3454 | |
| GSE29001 | HRH2 | 3274 | 220805_at | -0.0904 | 0.6145 | |
| GSE38129 | HRH2 | 3274 | 220805_at | -0.2457 | 0.0037 | |
| GSE45670 | HRH2 | 3274 | 220805_at | 0.1349 | 0.2482 | |
| GSE53622 | HRH2 | 3274 | 21320 | 0.1471 | 0.2222 | |
| GSE53624 | HRH2 | 3274 | 21320 | 0.2873 | 0.0031 | |
| GSE63941 | HRH2 | 3274 | 220805_at | 0.0211 | 0.9236 | |
| GSE77861 | HRH2 | 3274 | 220805_at | -0.2795 | 0.1256 | |
| GSE97050 | HRH2 | 3274 | A_23_P7535 | 0.3830 | 0.1836 | |
| SRP064894 | HRH2 | 3274 | RNAseq | 0.8508 | 0.0541 | |
| SRP133303 | HRH2 | 3274 | RNAseq | 0.4860 | 0.0923 | |
| SRP159526 | HRH2 | 3274 | RNAseq | 0.4044 | 0.3715 | |
| SRP193095 | HRH2 | 3274 | RNAseq | 0.8019 | 0.0215 | |
| SRP219564 | HRH2 | 3274 | RNAseq | 0.6010 | 0.3034 | |
| TCGA | HRH2 | 3274 | RNAseq | -1.5382 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HRH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HRH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HRH2 | 3274 | 2 | 13 | 15 | |
| GSE20123 | HRH2 | 3274 | 2 | 13 | 15 | |
| GSE43470 | HRH2 | 3274 | 1 | 10 | 32 | |
| GSE46452 | HRH2 | 3274 | 0 | 27 | 32 | |
| GSE47630 | HRH2 | 3274 | 0 | 20 | 20 | |
| GSE54993 | HRH2 | 3274 | 10 | 2 | 58 | |
| GSE54994 | HRH2 | 3274 | 2 | 17 | 34 | |
| GSE60625 | HRH2 | 3274 | 1 | 0 | 10 | |
| GSE74703 | HRH2 | 3274 | 1 | 7 | 28 | |
| GSE74704 | HRH2 | 3274 | 1 | 6 | 13 | |
| TCGA | HRH2 | 3274 | 7 | 35 | 54 |
Total number of gains: 27; Total number of losses: 150; Total Number of normals: 311.
Somatic mutations of HRH2:
Generating mutation plots.
Highly correlated genes for HRH2:
Showing top 20/967 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HRH2 | DLG4 | 0.746956 | 3 | 0 | 3 |
| HRH2 | NAALADL1 | 0.742309 | 4 | 0 | 4 |
| HRH2 | GJA4 | 0.72947 | 4 | 0 | 3 |
| HRH2 | KRT76 | 0.729414 | 4 | 0 | 4 |
| HRH2 | LINC00544 | 0.723306 | 3 | 0 | 3 |
| HRH2 | UMOD | 0.706614 | 4 | 0 | 4 |
| HRH2 | SOX10 | 0.700223 | 4 | 0 | 4 |
| HRH2 | CIITA | 0.69855 | 4 | 0 | 4 |
| HRH2 | A4GNT | 0.69739 | 3 | 0 | 3 |
| HRH2 | MLXIPL | 0.696 | 4 | 0 | 4 |
| HRH2 | ZMAT4 | 0.693783 | 4 | 0 | 3 |
| HRH2 | SIRPB1 | 0.692574 | 3 | 0 | 3 |
| HRH2 | ODF1 | 0.687556 | 4 | 0 | 4 |
| HRH2 | NEUROD6 | 0.687392 | 5 | 0 | 5 |
| HRH2 | HAS1 | 0.685231 | 4 | 0 | 3 |
| HRH2 | CACNA1H | 0.680602 | 4 | 0 | 4 |
| HRH2 | RPRML | 0.680069 | 3 | 0 | 3 |
| HRH2 | FRMPD4 | 0.673845 | 5 | 0 | 4 |
| HRH2 | XPNPEP2 | 0.671576 | 5 | 0 | 4 |
| HRH2 | PNPLA7 | 0.670751 | 3 | 0 | 3 |
For details and further investigation, click here
