| Full name: sodium voltage-gated channel alpha subunit 7 | Alias Symbol: Nav2.1|Nav2.2|NaG | ||
| Type: protein-coding gene | Cytoband: 2q24.3 | ||
| Entrez ID: 6332 | HGNC ID: HGNC:10594 | Ensembl Gene: ENSG00000136546 | OMIM ID: 182392 |
| Drug and gene relationship at DGIdb | |||
SCN7A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04261 | Adrenergic signaling in cardiomyocytes |
Expression of SCN7A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN7A | 6332 | 228504_at | -3.2744 | 0.0821 | |
| GSE20347 | SCN7A | 6332 | 207864_at | 0.0217 | 0.6963 | |
| GSE23400 | SCN7A | 6332 | 207864_at | -0.2360 | 0.0000 | |
| GSE26886 | SCN7A | 6332 | 228504_at | -0.1828 | 0.5813 | |
| GSE29001 | SCN7A | 6332 | 207864_at | -0.0701 | 0.5853 | |
| GSE38129 | SCN7A | 6332 | 207864_at | -0.1553 | 0.0938 | |
| GSE45670 | SCN7A | 6332 | 228504_at | -4.8148 | 0.0000 | |
| GSE53622 | SCN7A | 6332 | 53441 | -2.9223 | 0.0000 | |
| GSE53624 | SCN7A | 6332 | 53441 | -2.1865 | 0.0000 | |
| GSE63941 | SCN7A | 6332 | 228504_at | -4.2366 | 0.0000 | |
| GSE77861 | SCN7A | 6332 | 228504_at | -0.0555 | 0.6079 | |
| GSE97050 | SCN7A | 6332 | A_23_P90944 | -1.4217 | 0.1581 | |
| SRP007169 | SCN7A | 6332 | RNAseq | -1.1348 | 0.0439 | |
| SRP064894 | SCN7A | 6332 | RNAseq | -0.9164 | 0.1280 | |
| SRP133303 | SCN7A | 6332 | RNAseq | -3.0239 | 0.0000 | |
| SRP159526 | SCN7A | 6332 | RNAseq | -1.9780 | 0.0000 | |
| TCGA | SCN7A | 6332 | RNAseq | -1.9838 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by SCN7A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN7A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN7A | 6332 | 5 | 1 | 24 | |
| GSE20123 | SCN7A | 6332 | 4 | 1 | 25 | |
| GSE43470 | SCN7A | 6332 | 5 | 1 | 37 | |
| GSE46452 | SCN7A | 6332 | 1 | 4 | 54 | |
| GSE47630 | SCN7A | 6332 | 5 | 3 | 32 | |
| GSE54993 | SCN7A | 6332 | 0 | 5 | 65 | |
| GSE54994 | SCN7A | 6332 | 11 | 2 | 40 | |
| GSE60625 | SCN7A | 6332 | 0 | 3 | 8 | |
| GSE74703 | SCN7A | 6332 | 4 | 1 | 31 | |
| GSE74704 | SCN7A | 6332 | 2 | 0 | 18 | |
| TCGA | SCN7A | 6332 | 24 | 9 | 63 |
Total number of gains: 61; Total number of losses: 30; Total Number of normals: 397.
Somatic mutations of SCN7A:
Generating mutation plots.
Highly correlated genes for SCN7A:
Showing top 20/1234 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN7A | SORCS1 | 0.865978 | 4 | 0 | 4 |
| SCN7A | RBFOX3 | 0.845517 | 3 | 0 | 3 |
| SCN7A | NEGR1 | 0.833503 | 7 | 0 | 7 |
| SCN7A | ADAMTS9-AS2 | 0.830033 | 5 | 0 | 5 |
| SCN7A | PGM5-AS1 | 0.828402 | 3 | 0 | 3 |
| SCN7A | SYNPO2 | 0.821995 | 7 | 0 | 6 |
| SCN7A | PPP1R14A | 0.815797 | 5 | 0 | 5 |
| SCN7A | RBPMS2 | 0.815173 | 6 | 0 | 5 |
| SCN7A | PGM5 | 0.806886 | 9 | 0 | 8 |
| SCN7A | FENDRR | 0.800228 | 6 | 0 | 6 |
| SCN7A | MAGI2-AS3 | 0.797419 | 5 | 0 | 5 |
| SCN7A | EIF4E3 | 0.794144 | 5 | 0 | 5 |
| SCN7A | ANK2 | 0.792895 | 8 | 0 | 8 |
| SCN7A | ACTBL2 | 0.790325 | 3 | 0 | 3 |
| SCN7A | VIT | 0.784935 | 5 | 0 | 5 |
| SCN7A | NEXN | 0.781992 | 7 | 0 | 6 |
| SCN7A | LRRN4CL | 0.77973 | 6 | 0 | 6 |
| SCN7A | RGS7BP | 0.779302 | 5 | 0 | 5 |
| SCN7A | ABCA8 | 0.777427 | 9 | 0 | 9 |
| SCN7A | ASPA | 0.775617 | 9 | 0 | 9 |
For details and further investigation, click here
