| Full name: dopamine receptor D2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23.2 | ||
| Entrez ID: 1813 | HGNC ID: HGNC:3023 | Ensembl Gene: ENSG00000149295 | OMIM ID: 126450 |
| Drug and gene relationship at DGIdb | |||
DRD2 involved pathways:
Expression of DRD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DRD2 | 1813 | 216938_x_at | -0.0993 | 0.7012 | |
| GSE20347 | DRD2 | 1813 | 211624_s_at | -0.1344 | 0.1168 | |
| GSE23400 | DRD2 | 1813 | 206590_x_at | -0.1603 | 0.0002 | |
| GSE26886 | DRD2 | 1813 | 211624_s_at | -0.0552 | 0.6467 | |
| GSE29001 | DRD2 | 1813 | 206590_x_at | -0.1665 | 0.3364 | |
| GSE38129 | DRD2 | 1813 | 211624_s_at | -0.1970 | 0.0111 | |
| GSE45670 | DRD2 | 1813 | 211624_s_at | 0.0961 | 0.2597 | |
| GSE53622 | DRD2 | 1813 | 51772 | -0.6763 | 0.0000 | |
| GSE53624 | DRD2 | 1813 | 51772 | -0.3032 | 0.0228 | |
| GSE63941 | DRD2 | 1813 | 211624_s_at | 0.3670 | 0.0359 | |
| GSE77861 | DRD2 | 1813 | 211624_s_at | -0.0495 | 0.5939 | |
| GSE97050 | DRD2 | 1813 | A_33_P3733417 | -0.1154 | 0.6443 | |
| TCGA | DRD2 | 1813 | RNAseq | 0.3022 | 0.6074 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DRD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DRD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DRD2 | 1813 | 0 | 13 | 17 | |
| GSE20123 | DRD2 | 1813 | 0 | 13 | 17 | |
| GSE43470 | DRD2 | 1813 | 2 | 6 | 35 | |
| GSE46452 | DRD2 | 1813 | 3 | 26 | 30 | |
| GSE47630 | DRD2 | 1813 | 2 | 19 | 19 | |
| GSE54993 | DRD2 | 1813 | 10 | 0 | 60 | |
| GSE54994 | DRD2 | 1813 | 5 | 19 | 29 | |
| GSE60625 | DRD2 | 1813 | 0 | 3 | 8 | |
| GSE74703 | DRD2 | 1813 | 1 | 4 | 31 | |
| GSE74704 | DRD2 | 1813 | 0 | 9 | 11 | |
| TCGA | DRD2 | 1813 | 5 | 49 | 42 |
Total number of gains: 28; Total number of losses: 161; Total Number of normals: 299.
Somatic mutations of DRD2:
Generating mutation plots.
Highly correlated genes for DRD2:
Showing top 20/982 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DRD2 | ABCC6 | 0.788193 | 3 | 0 | 3 |
| DRD2 | TERT | 0.745735 | 5 | 0 | 5 |
| DRD2 | ADH6 | 0.729794 | 5 | 0 | 5 |
| DRD2 | ADAP1 | 0.715233 | 4 | 0 | 3 |
| DRD2 | CATSPER3 | 0.71042 | 3 | 0 | 3 |
| DRD2 | CCDC87 | 0.705836 | 4 | 0 | 4 |
| DRD2 | AMHR2 | 0.703803 | 7 | 0 | 6 |
| DRD2 | CDK16 | 0.700212 | 3 | 0 | 3 |
| DRD2 | MUC5AC | 0.697775 | 5 | 0 | 5 |
| DRD2 | ZGLP1 | 0.69745 | 4 | 0 | 3 |
| DRD2 | DAGLA | 0.697415 | 4 | 0 | 4 |
| DRD2 | GIP | 0.695562 | 3 | 0 | 3 |
| DRD2 | CYP17A1 | 0.693654 | 6 | 0 | 6 |
| DRD2 | SH2D1B | 0.693079 | 3 | 0 | 3 |
| DRD2 | ACR | 0.691948 | 7 | 0 | 6 |
| DRD2 | CYP2D6 | 0.690663 | 8 | 0 | 7 |
| DRD2 | GRIN1 | 0.689766 | 6 | 0 | 5 |
| DRD2 | ADCY1 | 0.68969 | 5 | 0 | 5 |
| DRD2 | CSRP3 | 0.688923 | 5 | 0 | 4 |
| DRD2 | MEPE | 0.688667 | 7 | 0 | 7 |
For details and further investigation, click here
