| Full name: diacylglycerol lipase alpha | Alias Symbol: KIAA0659|NSDDR|DAGLALPHA | ||
| Type: protein-coding gene | Cytoband: 11q12.2 | ||
| Entrez ID: 747 | HGNC ID: HGNC:1165 | Ensembl Gene: ENSG00000134780 | OMIM ID: 614015 |
| Drug and gene relationship at DGIdb | |||
Expression of DAGLA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DAGLA | 747 | 214128_at | -0.2104 | 0.4041 | |
| GSE20347 | DAGLA | 747 | 214128_at | -0.2537 | 0.0196 | |
| GSE23400 | DAGLA | 747 | 214128_at | -0.2280 | 0.0000 | |
| GSE26886 | DAGLA | 747 | 214128_at | -0.0051 | 0.9634 | |
| GSE29001 | DAGLA | 747 | 214128_at | -0.1282 | 0.4558 | |
| GSE38129 | DAGLA | 747 | 214128_at | -0.3238 | 0.0048 | |
| GSE45670 | DAGLA | 747 | 214128_at | -0.0765 | 0.4983 | |
| GSE63941 | DAGLA | 747 | 214128_at | 0.0815 | 0.7206 | |
| GSE77861 | DAGLA | 747 | 214128_at | -0.1395 | 0.2704 | |
| SRP007169 | DAGLA | 747 | RNAseq | -2.6593 | 0.0001 | |
| SRP008496 | DAGLA | 747 | RNAseq | -2.7205 | 0.0000 | |
| SRP064894 | DAGLA | 747 | RNAseq | -1.0168 | 0.0055 | |
| SRP133303 | DAGLA | 747 | RNAseq | -1.2702 | 0.0017 | |
| SRP159526 | DAGLA | 747 | RNAseq | -1.4439 | 0.0000 | |
| SRP193095 | DAGLA | 747 | RNAseq | -0.9456 | 0.0000 | |
| SRP219564 | DAGLA | 747 | RNAseq | -1.3470 | 0.0620 | |
| TCGA | DAGLA | 747 | RNAseq | -0.5241 | 0.0014 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by DAGLA expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DAGLA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DAGLA | 747 | 4 | 5 | 21 | |
| GSE20123 | DAGLA | 747 | 4 | 5 | 21 | |
| GSE43470 | DAGLA | 747 | 2 | 6 | 35 | |
| GSE46452 | DAGLA | 747 | 8 | 4 | 47 | |
| GSE47630 | DAGLA | 747 | 3 | 8 | 29 | |
| GSE54993 | DAGLA | 747 | 3 | 0 | 67 | |
| GSE54994 | DAGLA | 747 | 5 | 5 | 43 | |
| GSE60625 | DAGLA | 747 | 0 | 3 | 8 | |
| GSE74703 | DAGLA | 747 | 2 | 3 | 31 | |
| GSE74704 | DAGLA | 747 | 3 | 3 | 14 | |
| TCGA | DAGLA | 747 | 14 | 10 | 72 |
Total number of gains: 48; Total number of losses: 52; Total Number of normals: 388.
Somatic mutations of DAGLA:
Generating mutation plots.
Highly correlated genes for DAGLA:
Showing top 20/945 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DAGLA | PF4 | 0.733415 | 3 | 0 | 3 |
| DAGLA | PAX3 | 0.719465 | 4 | 0 | 4 |
| DAGLA | STXBP6 | 0.718459 | 3 | 0 | 3 |
| DAGLA | FASLG | 0.709069 | 5 | 0 | 5 |
| DAGLA | SLC22A14 | 0.70827 | 5 | 0 | 5 |
| DAGLA | MAP1A | 0.707655 | 3 | 0 | 3 |
| DAGLA | IL34 | 0.705585 | 3 | 0 | 3 |
| DAGLA | DRD2 | 0.697415 | 4 | 0 | 4 |
| DAGLA | MRPL41 | 0.693605 | 3 | 0 | 3 |
| DAGLA | CST8 | 0.68801 | 4 | 0 | 4 |
| DAGLA | IL17RC | 0.685648 | 5 | 0 | 5 |
| DAGLA | LIMS2 | 0.684419 | 3 | 0 | 3 |
| DAGLA | HHLA1 | 0.683253 | 5 | 0 | 5 |
| DAGLA | KCNQ4 | 0.68011 | 6 | 0 | 6 |
| DAGLA | MVK | 0.679244 | 5 | 0 | 4 |
| DAGLA | TSHB | 0.678053 | 6 | 0 | 6 |
| DAGLA | ADM2 | 0.675413 | 5 | 0 | 4 |
| DAGLA | MYOC | 0.673727 | 3 | 0 | 3 |
| DAGLA | KIAA1614 | 0.67242 | 6 | 0 | 5 |
| DAGLA | GDF10 | 0.671929 | 4 | 0 | 4 |
For details and further investigation, click here
