| Full name: dopamine receptor D5 | Alias Symbol: DRD1B | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 1816 | HGNC ID: HGNC:3026 | Ensembl Gene: ENSG00000169676 | OMIM ID: 126453 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DRD5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04728 | Dopaminergic synapse |
Expression of DRD5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DRD5 | 1816 | 208486_at | 0.0038 | 0.9891 | |
| GSE20347 | DRD5 | 1816 | 208486_at | -0.0309 | 0.7650 | |
| GSE23400 | DRD5 | 1816 | 208486_at | -0.2308 | 0.0002 | |
| GSE26886 | DRD5 | 1816 | 208486_at | 0.1533 | 0.1503 | |
| GSE29001 | DRD5 | 1816 | 208486_at | -0.2215 | 0.1888 | |
| GSE38129 | DRD5 | 1816 | 208486_at | -0.1530 | 0.1659 | |
| GSE45670 | DRD5 | 1816 | 208486_at | 0.0582 | 0.5051 | |
| GSE63941 | DRD5 | 1816 | 208486_at | 0.1057 | 0.6018 | |
| GSE77861 | DRD5 | 1816 | 208486_at | -0.0233 | 0.8526 | |
| GSE97050 | DRD5 | 1816 | A_24_P862886 | -0.1183 | 0.8251 | |
| TCGA | DRD5 | 1816 | RNAseq | -0.1419 | 0.7707 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DRD5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DRD5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DRD5 | 1816 | 0 | 17 | 13 | |
| GSE20123 | DRD5 | 1816 | 0 | 17 | 13 | |
| GSE43470 | DRD5 | 1816 | 1 | 16 | 26 | |
| GSE46452 | DRD5 | 1816 | 1 | 36 | 22 | |
| GSE47630 | DRD5 | 1816 | 1 | 19 | 20 | |
| GSE54993 | DRD5 | 1816 | 10 | 0 | 60 | |
| GSE54994 | DRD5 | 1816 | 4 | 12 | 37 | |
| GSE60625 | DRD5 | 1816 | 0 | 0 | 11 | |
| GSE74703 | DRD5 | 1816 | 1 | 13 | 22 | |
| GSE74704 | DRD5 | 1816 | 0 | 10 | 10 | |
| TCGA | DRD5 | 1816 | 9 | 47 | 40 |
Total number of gains: 27; Total number of losses: 187; Total Number of normals: 274.
Somatic mutations of DRD5:
Generating mutation plots.
Highly correlated genes for DRD5:
Showing top 20/875 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DRD5 | PHLDB1 | 0.758032 | 6 | 0 | 6 |
| DRD5 | NCR2 | 0.75219 | 4 | 0 | 4 |
| DRD5 | SLC6A5 | 0.747768 | 4 | 0 | 4 |
| DRD5 | SHBG | 0.742596 | 4 | 0 | 4 |
| DRD5 | OR6A2 | 0.741424 | 4 | 0 | 4 |
| DRD5 | LALBA | 0.738105 | 4 | 0 | 4 |
| DRD5 | NTNG1 | 0.731379 | 4 | 0 | 4 |
| DRD5 | OR7C2 | 0.730385 | 4 | 0 | 4 |
| DRD5 | ZMAT4 | 0.724912 | 3 | 0 | 3 |
| DRD5 | SLC2A2 | 0.72087 | 3 | 0 | 3 |
| DRD5 | USP29 | 0.717568 | 4 | 0 | 4 |
| DRD5 | ITGB3 | 0.713892 | 4 | 0 | 4 |
| DRD5 | AMELY | 0.71353 | 4 | 0 | 4 |
| DRD5 | EDA2R | 0.713095 | 5 | 0 | 5 |
| DRD5 | FSTL4 | 0.71307 | 3 | 0 | 3 |
| DRD5 | G6PC2 | 0.712071 | 5 | 0 | 5 |
| DRD5 | LAMP1 | 0.709403 | 3 | 0 | 3 |
| DRD5 | PDYN | 0.707569 | 4 | 0 | 4 |
| DRD5 | GABRA5 | 0.704355 | 3 | 0 | 3 |
| DRD5 | FOXN3-AS2 | 0.703077 | 5 | 0 | 5 |
For details and further investigation, click here
