| Full name: prodynorphin | Alias Symbol: PENKB|ADCA | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 5173 | HGNC ID: HGNC:8820 | Ensembl Gene: ENSG00000101327 | OMIM ID: 131340 |
| Drug and gene relationship at DGIdb | |||
PDYN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05030 | Cocaine addiction | |
| hsa05031 | Amphetamine addiction | |
| hsa05034 | Alcoholism |
Expression of PDYN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDYN | 5173 | 206803_at | -0.1221 | 0.6672 | |
| GSE20347 | PDYN | 5173 | 206803_at | -0.0815 | 0.3752 | |
| GSE23400 | PDYN | 5173 | 206803_at | -0.2934 | 0.0000 | |
| GSE26886 | PDYN | 5173 | 206803_at | -0.3298 | 0.0211 | |
| GSE29001 | PDYN | 5173 | 206803_at | -0.3680 | 0.0545 | |
| GSE38129 | PDYN | 5173 | 206803_at | -0.1719 | 0.0464 | |
| GSE45670 | PDYN | 5173 | 206803_at | 0.1296 | 0.2563 | |
| GSE53622 | PDYN | 5173 | 64572 | 0.5590 | 0.0131 | |
| GSE53624 | PDYN | 5173 | 64572 | 0.3223 | 0.0030 | |
| GSE63941 | PDYN | 5173 | 206803_at | 0.2615 | 0.0386 | |
| GSE77861 | PDYN | 5173 | 206803_at | -0.2185 | 0.0202 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDYN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDYN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDYN | 5173 | 12 | 3 | 15 | |
| GSE20123 | PDYN | 5173 | 13 | 3 | 14 | |
| GSE43470 | PDYN | 5173 | 11 | 1 | 31 | |
| GSE46452 | PDYN | 5173 | 26 | 1 | 32 | |
| GSE47630 | PDYN | 5173 | 18 | 4 | 18 | |
| GSE54993 | PDYN | 5173 | 2 | 14 | 54 | |
| GSE54994 | PDYN | 5173 | 24 | 2 | 27 | |
| GSE60625 | PDYN | 5173 | 0 | 0 | 11 | |
| GSE74703 | PDYN | 5173 | 10 | 1 | 25 | |
| GSE74704 | PDYN | 5173 | 8 | 1 | 11 | |
| TCGA | PDYN | 5173 | 40 | 11 | 45 |
Total number of gains: 164; Total number of losses: 41; Total Number of normals: 283.
Somatic mutations of PDYN:
Generating mutation plots.
Highly correlated genes for PDYN:
Showing top 20/1187 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDYN | PHF7 | 0.729255 | 7 | 0 | 7 |
| PDYN | TUB | 0.728283 | 4 | 0 | 4 |
| PDYN | KIAA1614 | 0.720869 | 7 | 0 | 7 |
| PDYN | LINC00523 | 0.716201 | 3 | 0 | 3 |
| PDYN | HHLA1 | 0.708716 | 5 | 0 | 4 |
| PDYN | DRD5 | 0.707569 | 4 | 0 | 4 |
| PDYN | MAP3K19 | 0.704317 | 5 | 0 | 5 |
| PDYN | MTAP | 0.702732 | 4 | 0 | 4 |
| PDYN | MC5R | 0.7026 | 5 | 0 | 5 |
| PDYN | UMOD | 0.699691 | 6 | 0 | 6 |
| PDYN | GPD1 | 0.699398 | 3 | 0 | 3 |
| PDYN | ACR | 0.696119 | 4 | 0 | 4 |
| PDYN | SLC10A1 | 0.694241 | 6 | 0 | 4 |
| PDYN | KIRREL3-AS2 | 0.693862 | 3 | 0 | 3 |
| PDYN | USH1C | 0.693246 | 4 | 0 | 4 |
| PDYN | GUCA2B | 0.690489 | 6 | 0 | 6 |
| PDYN | IL12RB1 | 0.690229 | 6 | 0 | 6 |
| PDYN | AMACR | 0.688263 | 5 | 0 | 5 |
| PDYN | TUBB4A | 0.685754 | 5 | 0 | 5 |
| PDYN | IFNA21 | 0.684801 | 7 | 0 | 5 |
For details and further investigation, click here
