S1PR5

 

Full name: sphingosine-1-phosphate receptor 5 Alias Symbol: Edg-8
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 53637 HGNC ID: HGNC:14299 Ensembl Gene: ENSG00000180739 OMIM ID: 605146
Drug and gene relationship at DGIdb

 

S1PR5 involved pathways:

KEGG pathway Description View
hsa04071Sphingolipid signaling pathway

 

Expression of S1PR5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 S1PR5 53637 230464_at 0.5878 0.3436
GSE20347 S1PR5 53637 221417_x_at 0.0435 0.5044
GSE23400 S1PR5 53637 221417_x_at 0.0646 0.0954
GSE26886 S1PR5 53637 230464_at -0.4220 0.1101
GSE29001 S1PR5 53637 221417_x_at 0.0098 0.9410
GSE38129 S1PR5 53637 221417_x_at 0.0924 0.1479
GSE45670 S1PR5 53637 230464_at 0.8883 0.0001
GSE53622 S1PR5 53637 36714 0.8459 0.0002
GSE53624 S1PR5 53637 36714 0.7218 0.0000
GSE63941 S1PR5 53637 230464_at 2.3141 0.0069
GSE77861 S1PR5 53637 230464_at 0.1417 0.6341
GSE97050 S1PR5 53637 A_23_P107744 0.2936 0.3692
SRP007169 S1PR5 53637 RNAseq 1.0570 0.0232
SRP008496 S1PR5 53637 RNAseq 0.9559 0.0070
SRP064894 S1PR5 53637 RNAseq 0.8352 0.0128
SRP133303 S1PR5 53637 RNAseq 0.3980 0.1597
SRP159526 S1PR5 53637 RNAseq 0.4650 0.2146
SRP219564 S1PR5 53637 RNAseq 0.1296 0.8825
TCGA S1PR5 53637 RNAseq 1.9829 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by S1PR5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of S1PR5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 S1PR5 53637 4 3 23
GSE20123 S1PR5 53637 3 1 26
GSE43470 S1PR5 53637 3 6 34
GSE46452 S1PR5 53637 47 1 11
GSE47630 S1PR5 53637 4 7 29
GSE54993 S1PR5 53637 16 3 51
GSE54994 S1PR5 53637 7 13 33
GSE60625 S1PR5 53637 9 0 2
GSE74703 S1PR5 53637 3 4 29
GSE74704 S1PR5 53637 0 1 19
TCGA S1PR5 53637 15 14 67

Total number of gains: 111; Total number of losses: 53; Total Number of normals: 324.  

 

Somatic mutations of S1PR5:

 

Generating mutation plots.

 

Highly correlated genes for S1PR5:

 

Showing top 20/559 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
S1PR5COPE0.768041303
S1PR5NUDT210.75901303
S1PR5E2F80.750917303
S1PR5TRAF30.749843303
S1PR5LSM40.742989303
S1PR5MRPL210.731515303
S1PR5TNFAIP10.729671303
S1PR5IFFO20.725638303
S1PR5TUFM0.721519303
S1PR5RAB120.720611303
S1PR5CHMP1B0.719524303
S1PR5FAM32A0.71524303
S1PR5SNX120.714941303
S1PR5WDR770.710521404
S1PR5EIF2A0.705653303
S1PR5TMEM540.704299505
S1PR5SPATS20.70203303
S1PR5TERF20.701037303
S1PR5CDK5R10.694751403
S1PR5NFKB20.693794303

For details and further investigation, click here