| Full name: cytochrome P450 family 4 subfamily X member 1 | Alias Symbol: MGC40051 | ||
| Type: protein-coding gene | Cytoband: 1p33 | ||
| Entrez ID: 260293 | HGNC ID: HGNC:20244 | Ensembl Gene: ENSG00000186377 | OMIM ID: 614999 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP4X1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP4X1 | 260293 | 227702_at | -0.2021 | 0.6462 | |
| GSE26886 | CYP4X1 | 260293 | 227702_at | -2.4598 | 0.0072 | |
| GSE45670 | CYP4X1 | 260293 | 227702_at | -0.2679 | 0.6770 | |
| GSE53622 | CYP4X1 | 260293 | 102312 | -1.5521 | 0.0000 | |
| GSE53624 | CYP4X1 | 260293 | 102312 | -2.0434 | 0.0000 | |
| GSE63941 | CYP4X1 | 260293 | 227702_at | 1.6054 | 0.3494 | |
| GSE77861 | CYP4X1 | 260293 | 227702_at | -1.8973 | 0.0246 | |
| GSE97050 | CYP4X1 | 260293 | A_24_P293530 | -0.0676 | 0.9277 | |
| SRP007169 | CYP4X1 | 260293 | RNAseq | -4.5861 | 0.0000 | |
| SRP064894 | CYP4X1 | 260293 | RNAseq | -1.6643 | 0.0000 | |
| SRP133303 | CYP4X1 | 260293 | RNAseq | -0.7437 | 0.0216 | |
| SRP159526 | CYP4X1 | 260293 | RNAseq | -1.1477 | 0.0082 | |
| SRP193095 | CYP4X1 | 260293 | RNAseq | -0.4130 | 0.1625 | |
| SRP219564 | CYP4X1 | 260293 | RNAseq | -0.4503 | 0.6416 | |
| TCGA | CYP4X1 | 260293 | RNAseq | -0.5703 | 0.0840 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by CYP4X1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP4X1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP4X1 | 260293 | 4 | 3 | 23 | |
| GSE20123 | CYP4X1 | 260293 | 4 | 2 | 24 | |
| GSE43470 | CYP4X1 | 260293 | 5 | 1 | 37 | |
| GSE46452 | CYP4X1 | 260293 | 2 | 1 | 56 | |
| GSE47630 | CYP4X1 | 260293 | 8 | 4 | 28 | |
| GSE54993 | CYP4X1 | 260293 | 0 | 1 | 69 | |
| GSE54994 | CYP4X1 | 260293 | 11 | 2 | 40 | |
| GSE60625 | CYP4X1 | 260293 | 0 | 0 | 11 | |
| GSE74703 | CYP4X1 | 260293 | 4 | 1 | 31 | |
| GSE74704 | CYP4X1 | 260293 | 2 | 0 | 18 | |
| TCGA | CYP4X1 | 260293 | 11 | 16 | 69 |
Total number of gains: 51; Total number of losses: 31; Total Number of normals: 406.
Somatic mutations of CYP4X1:
Generating mutation plots.
Highly correlated genes for CYP4X1:
Showing top 20/718 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP4X1 | ALDH3B2 | 0.788062 | 3 | 0 | 3 |
| CYP4X1 | E2F8 | 0.770823 | 3 | 0 | 3 |
| CYP4X1 | SLC10A5 | 0.705553 | 3 | 0 | 3 |
| CYP4X1 | HSD17B4 | 0.703328 | 7 | 0 | 7 |
| CYP4X1 | DHRS3 | 0.697912 | 7 | 0 | 7 |
| CYP4X1 | OXSM | 0.687064 | 4 | 0 | 4 |
| CYP4X1 | IMPACT | 0.68375 | 3 | 0 | 3 |
| CYP4X1 | PTPRA | 0.68126 | 3 | 0 | 3 |
| CYP4X1 | RAP2C | 0.680932 | 3 | 0 | 3 |
| CYP4X1 | PPP1R3D | 0.678444 | 4 | 0 | 3 |
| CYP4X1 | CASP1 | 0.675451 | 4 | 0 | 4 |
| CYP4X1 | TNFAIP8 | 0.674188 | 3 | 0 | 3 |
| CYP4X1 | STT3B | 0.673017 | 5 | 0 | 5 |
| CYP4X1 | TRIM5 | 0.668584 | 3 | 0 | 3 |
| CYP4X1 | CASP4 | 0.666735 | 4 | 0 | 4 |
| CYP4X1 | PGM2 | 0.666444 | 6 | 0 | 4 |
| CYP4X1 | LNX1 | 0.666397 | 6 | 0 | 5 |
| CYP4X1 | SCP2 | 0.662481 | 7 | 0 | 7 |
| CYP4X1 | PTPN13 | 0.66138 | 4 | 0 | 3 |
| CYP4X1 | ACOX3 | 0.65848 | 7 | 0 | 7 |
For details and further investigation, click here
