| Full name: protein phosphatase 1 regulatory subunit 8 | Alias Symbol: ard-1|NIPP-1|PRO2047|ARD1|NIPP1 | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 5511 | HGNC ID: HGNC:9296 | Ensembl Gene: ENSG00000117751 | OMIM ID: 602636 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPP1R8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R8 | 5511 | 207830_s_at | 0.0216 | 0.9586 | |
| GSE20347 | PPP1R8 | 5511 | 207830_s_at | 0.1457 | 0.2489 | |
| GSE23400 | PPP1R8 | 5511 | 207830_s_at | 0.3508 | 0.0000 | |
| GSE26886 | PPP1R8 | 5511 | 207830_s_at | -0.6330 | 0.0077 | |
| GSE29001 | PPP1R8 | 5511 | 207830_s_at | 0.3715 | 0.0809 | |
| GSE38129 | PPP1R8 | 5511 | 207830_s_at | 0.1589 | 0.0925 | |
| GSE45670 | PPP1R8 | 5511 | 207830_s_at | 0.0987 | 0.3125 | |
| GSE53622 | PPP1R8 | 5511 | 9534 | -0.0601 | 0.2607 | |
| GSE53624 | PPP1R8 | 5511 | 62234 | 0.0333 | 0.4771 | |
| GSE63941 | PPP1R8 | 5511 | 207830_s_at | 0.0979 | 0.6693 | |
| GSE77861 | PPP1R8 | 5511 | 207830_s_at | -0.0423 | 0.8685 | |
| GSE97050 | PPP1R8 | 5511 | A_24_P139773 | 0.3139 | 0.2826 | |
| SRP007169 | PPP1R8 | 5511 | RNAseq | 0.3973 | 0.3840 | |
| SRP008496 | PPP1R8 | 5511 | RNAseq | 0.2606 | 0.3973 | |
| SRP064894 | PPP1R8 | 5511 | RNAseq | 0.1315 | 0.2953 | |
| SRP133303 | PPP1R8 | 5511 | RNAseq | 0.3553 | 0.0250 | |
| SRP159526 | PPP1R8 | 5511 | RNAseq | 0.0214 | 0.9179 | |
| SRP193095 | PPP1R8 | 5511 | RNAseq | -0.0973 | 0.2654 | |
| SRP219564 | PPP1R8 | 5511 | RNAseq | -0.0721 | 0.6886 | |
| TCGA | PPP1R8 | 5511 | RNAseq | 0.1323 | 0.0113 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R8 | 5511 | 0 | 6 | 24 | |
| GSE20123 | PPP1R8 | 5511 | 0 | 5 | 25 | |
| GSE43470 | PPP1R8 | 5511 | 3 | 6 | 34 | |
| GSE46452 | PPP1R8 | 5511 | 5 | 1 | 53 | |
| GSE47630 | PPP1R8 | 5511 | 8 | 3 | 29 | |
| GSE54993 | PPP1R8 | 5511 | 2 | 1 | 67 | |
| GSE54994 | PPP1R8 | 5511 | 10 | 4 | 39 | |
| GSE60625 | PPP1R8 | 5511 | 0 | 0 | 11 | |
| GSE74703 | PPP1R8 | 5511 | 2 | 4 | 30 | |
| GSE74704 | PPP1R8 | 5511 | 0 | 0 | 20 | |
| TCGA | PPP1R8 | 5511 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.
Somatic mutations of PPP1R8:
Generating mutation plots.
Highly correlated genes for PPP1R8:
Showing top 20/678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R8 | PPCS | 0.783086 | 3 | 0 | 3 |
| PPP1R8 | GALNT7 | 0.774135 | 3 | 0 | 3 |
| PPP1R8 | ZMYND11 | 0.764866 | 3 | 0 | 3 |
| PPP1R8 | RBM23 | 0.762911 | 3 | 0 | 3 |
| PPP1R8 | DPM1 | 0.758895 | 4 | 0 | 4 |
| PPP1R8 | PPP2CA | 0.753893 | 3 | 0 | 3 |
| PPP1R8 | LETMD1 | 0.751464 | 3 | 0 | 3 |
| PPP1R8 | E2F8 | 0.751375 | 3 | 0 | 3 |
| PPP1R8 | AP3M1 | 0.748687 | 3 | 0 | 3 |
| PPP1R8 | MSH2 | 0.746979 | 5 | 0 | 5 |
| PPP1R8 | EIF4E | 0.744352 | 4 | 0 | 4 |
| PPP1R8 | HOOK3 | 0.742818 | 3 | 0 | 3 |
| PPP1R8 | PRPF38A | 0.742362 | 4 | 0 | 3 |
| PPP1R8 | ATP6V1B2 | 0.735878 | 4 | 0 | 4 |
| PPP1R8 | MRPL37 | 0.734738 | 4 | 0 | 3 |
| PPP1R8 | SPATA5L1 | 0.730775 | 3 | 0 | 3 |
| PPP1R8 | CAPN7 | 0.727659 | 3 | 0 | 3 |
| PPP1R8 | EED | 0.725386 | 3 | 0 | 3 |
| PPP1R8 | USP14 | 0.724888 | 3 | 0 | 3 |
| PPP1R8 | TRAFD1 | 0.720041 | 3 | 0 | 3 |
For details and further investigation, click here
