| Full name: ER degradation enhancing alpha-mannosidase like protein 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 80267 | HGNC ID: HGNC:16787 | Ensembl Gene: ENSG00000116406 | OMIM ID: 610214 |
| Drug and gene relationship at DGIdb | |||
Expression of EDEM3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDEM3 | 80267 | 223243_s_at | 0.3889 | 0.3679 | |
| GSE20347 | EDEM3 | 80267 | 220926_s_at | 0.3387 | 0.0756 | |
| GSE23400 | EDEM3 | 80267 | 220342_x_at | 0.2490 | 0.0019 | |
| GSE26886 | EDEM3 | 80267 | 223243_s_at | -0.6008 | 0.0952 | |
| GSE29001 | EDEM3 | 80267 | 220926_s_at | 0.4000 | 0.2695 | |
| GSE38129 | EDEM3 | 80267 | 220926_s_at | 0.3604 | 0.0160 | |
| GSE45670 | EDEM3 | 80267 | 220926_s_at | 0.4817 | 0.0003 | |
| GSE53622 | EDEM3 | 80267 | 21428 | -0.0720 | 0.3588 | |
| GSE53624 | EDEM3 | 80267 | 21428 | 0.0092 | 0.8823 | |
| GSE63941 | EDEM3 | 80267 | 223243_s_at | -0.7445 | 0.1104 | |
| GSE77861 | EDEM3 | 80267 | 223243_s_at | 0.8431 | 0.0502 | |
| GSE97050 | EDEM3 | 80267 | A_24_P208045 | 0.1886 | 0.4953 | |
| SRP007169 | EDEM3 | 80267 | RNAseq | 0.5406 | 0.1494 | |
| SRP008496 | EDEM3 | 80267 | RNAseq | 0.8832 | 0.0007 | |
| SRP064894 | EDEM3 | 80267 | RNAseq | 0.3040 | 0.2464 | |
| SRP133303 | EDEM3 | 80267 | RNAseq | 0.3874 | 0.0039 | |
| SRP159526 | EDEM3 | 80267 | RNAseq | 0.2461 | 0.3764 | |
| SRP193095 | EDEM3 | 80267 | RNAseq | -0.4330 | 0.0817 | |
| SRP219564 | EDEM3 | 80267 | RNAseq | 0.3422 | 0.2792 | |
| TCGA | EDEM3 | 80267 | RNAseq | -0.2414 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EDEM3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDEM3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDEM3 | 80267 | 12 | 0 | 18 | |
| GSE20123 | EDEM3 | 80267 | 12 | 0 | 18 | |
| GSE43470 | EDEM3 | 80267 | 7 | 1 | 35 | |
| GSE46452 | EDEM3 | 80267 | 3 | 1 | 55 | |
| GSE47630 | EDEM3 | 80267 | 14 | 0 | 26 | |
| GSE54993 | EDEM3 | 80267 | 0 | 6 | 64 | |
| GSE54994 | EDEM3 | 80267 | 15 | 0 | 38 | |
| GSE60625 | EDEM3 | 80267 | 0 | 0 | 11 | |
| GSE74703 | EDEM3 | 80267 | 7 | 1 | 28 | |
| GSE74704 | EDEM3 | 80267 | 5 | 0 | 15 | |
| TCGA | EDEM3 | 80267 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of EDEM3:
Generating mutation plots.
Highly correlated genes for EDEM3:
Showing top 20/146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDEM3 | NAA25 | 0.72419 | 3 | 0 | 3 |
| EDEM3 | CENPL | 0.69868 | 3 | 0 | 3 |
| EDEM3 | OSBPL11 | 0.655262 | 6 | 0 | 5 |
| EDEM3 | RANBP2 | 0.652184 | 4 | 0 | 4 |
| EDEM3 | XPO5 | 0.651638 | 3 | 0 | 3 |
| EDEM3 | FBXO45 | 0.644186 | 3 | 0 | 3 |
| EDEM3 | SF3A3 | 0.642517 | 3 | 0 | 3 |
| EDEM3 | YEATS4 | 0.642329 | 5 | 0 | 4 |
| EDEM3 | DNAJC16 | 0.640185 | 5 | 0 | 3 |
| EDEM3 | C16orf91 | 0.637077 | 4 | 0 | 3 |
| EDEM3 | EMC8 | 0.623545 | 3 | 0 | 3 |
| EDEM3 | EDNRA | 0.620447 | 4 | 0 | 3 |
| EDEM3 | BUD13 | 0.617522 | 3 | 0 | 3 |
| EDEM3 | GPR180 | 0.617513 | 3 | 0 | 3 |
| EDEM3 | FKBP14 | 0.617045 | 5 | 0 | 3 |
| EDEM3 | CEBPG | 0.609962 | 4 | 0 | 3 |
| EDEM3 | ZNF184 | 0.604917 | 7 | 0 | 5 |
| EDEM3 | ODF2 | 0.602953 | 4 | 0 | 3 |
| EDEM3 | PERP | 0.602678 | 3 | 0 | 3 |
| EDEM3 | MRPS17 | 0.600089 | 5 | 0 | 4 |
For details and further investigation, click here
