| Full name: centromere protein L | Alias Symbol: dJ383J4.3|FLJ31044 | ||
| Type: protein-coding gene | Cytoband: 1q25.1 | ||
| Entrez ID: 91687 | HGNC ID: HGNC:17879 | Ensembl Gene: ENSG00000120334 | OMIM ID: 611503 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CENPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CENPL | 91687 | 1554271_a_at | 0.9984 | 0.0749 | |
| GSE26886 | CENPL | 91687 | 232065_x_at | 1.4284 | 0.0000 | |
| GSE45670 | CENPL | 91687 | 232065_x_at | 0.8806 | 0.0000 | |
| GSE53622 | CENPL | 91687 | 86552 | 1.1591 | 0.0000 | |
| GSE53624 | CENPL | 91687 | 86552 | 1.6603 | 0.0000 | |
| GSE63941 | CENPL | 91687 | 232065_x_at | 0.7857 | 0.0098 | |
| GSE77861 | CENPL | 91687 | 232065_x_at | 0.8553 | 0.0073 | |
| GSE97050 | CENPL | 91687 | A_23_P126120 | 0.2448 | 0.3040 | |
| SRP007169 | CENPL | 91687 | RNAseq | 1.6245 | 0.0003 | |
| SRP008496 | CENPL | 91687 | RNAseq | 1.7796 | 0.0000 | |
| SRP064894 | CENPL | 91687 | RNAseq | 1.2283 | 0.0000 | |
| SRP133303 | CENPL | 91687 | RNAseq | 1.1589 | 0.0000 | |
| SRP159526 | CENPL | 91687 | RNAseq | 1.5867 | 0.0000 | |
| SRP193095 | CENPL | 91687 | RNAseq | 0.8814 | 0.0000 | |
| SRP219564 | CENPL | 91687 | RNAseq | 1.3043 | 0.0007 | |
| TCGA | CENPL | 91687 | RNAseq | 0.5775 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by CENPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CENPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CENPL | 91687 | 12 | 0 | 18 | |
| GSE20123 | CENPL | 91687 | 12 | 0 | 18 | |
| GSE43470 | CENPL | 91687 | 7 | 2 | 34 | |
| GSE46452 | CENPL | 91687 | 3 | 1 | 55 | |
| GSE47630 | CENPL | 91687 | 14 | 0 | 26 | |
| GSE54993 | CENPL | 91687 | 0 | 6 | 64 | |
| GSE54994 | CENPL | 91687 | 15 | 0 | 38 | |
| GSE60625 | CENPL | 91687 | 0 | 0 | 11 | |
| GSE74703 | CENPL | 91687 | 7 | 2 | 27 | |
| GSE74704 | CENPL | 91687 | 5 | 0 | 15 | |
| TCGA | CENPL | 91687 | 41 | 4 | 51 |
Total number of gains: 116; Total number of losses: 15; Total Number of normals: 357.
Somatic mutations of CENPL:
Generating mutation plots.
Highly correlated genes for CENPL:
Showing top 20/2072 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CENPL | BLM | 0.795144 | 8 | 0 | 8 |
| CENPL | TAF1A | 0.784712 | 5 | 0 | 5 |
| CENPL | BORA | 0.779431 | 6 | 0 | 6 |
| CENPL | CDCA2 | 0.779238 | 6 | 0 | 6 |
| CENPL | MMS22L | 0.77715 | 3 | 0 | 3 |
| CENPL | MEX3B | 0.77605 | 3 | 0 | 3 |
| CENPL | ECT2 | 0.775207 | 7 | 0 | 7 |
| CENPL | KIF18A | 0.769318 | 8 | 0 | 8 |
| CENPL | ZNF707 | 0.767124 | 3 | 0 | 3 |
| CENPL | UBE2T | 0.765851 | 8 | 0 | 8 |
| CENPL | ALG10B | 0.765553 | 3 | 0 | 3 |
| CENPL | HAS3 | 0.762886 | 3 | 0 | 3 |
| CENPL | NQO2 | 0.762706 | 3 | 0 | 3 |
| CENPL | U2SURP | 0.76269 | 5 | 0 | 5 |
| CENPL | BUB1 | 0.762444 | 8 | 0 | 8 |
| CENPL | MET | 0.762175 | 6 | 0 | 6 |
| CENPL | TOR3A | 0.762082 | 5 | 0 | 5 |
| CENPL | WDHD1 | 0.760221 | 8 | 0 | 8 |
| CENPL | TTK | 0.760081 | 8 | 0 | 8 |
| CENPL | SLC38A6 | 0.75988 | 5 | 0 | 5 |
For details and further investigation, click here
