Full name: exportin 5	Alias Symbol: KIAA1291
Type: protein-coding gene	Cytoband: 6p21.1
Entrez ID: 57510	HGNC ID: HGNC:17675	Ensembl Gene: ENSG00000124571	OMIM ID: 607845
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 40/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of XPO5:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	XPO5	57510	223056_s_at	1.2990	0.0143	Show
GSE26886	XPO5	57510	223056_s_at	0.5935	0.0000	Show
GSE45670	XPO5	57510	223056_s_at	0.7105	0.0000	Show
GSE53622	XPO5	57510	139586	0.6763	0.0000	Show
GSE53624	XPO5	57510	89693	0.7260	0.0000	Show
GSE63941	XPO5	57510	223056_s_at	0.8865	0.0297	Show
GSE77861	XPO5	57510	223056_s_at	0.4113	0.0402	Show
GSE97050	XPO5	57510	A_33_P3228366	0.5145	0.2561	Show
SRP007169	XPO5	57510	RNAseq	0.8857	0.0029	Show
SRP008496	XPO5	57510	RNAseq	0.8665	0.0000	Show
SRP064894	XPO5	57510	RNAseq	0.7197	0.0006	Show
SRP133303	XPO5	57510	RNAseq	0.5508	0.0000	Show
SRP159526	XPO5	57510	RNAseq	0.5843	0.0031	Show
SRP193095	XPO5	57510	RNAseq	0.4889	0.0000	Show
SRP219564	XPO5	57510	RNAseq	0.4967	0.2422	Show
TCGA	XPO5	57510	RNAseq	0.2091	0.0001	Show

Upregulated datasets: 1; Downregulated datasets: 0.  Download Data

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Survival by XPO5 expression:

 

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Copy number change of XPO5:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	XPO5	57510	7	0	23	Show
GSE20123	XPO5	57510	7	0	23	Show
GSE43470	XPO5	57510	6	0	37	Show
GSE46452	XPO5	57510	2	9	48	Show
GSE47630	XPO5	57510	8	4	28	Show
GSE54993	XPO5	57510	3	2	65	Show
GSE54994	XPO5	57510	11	4	38	Show
GSE60625	XPO5	57510	0	1	10	Show
GSE74703	XPO5	57510	6	0	30	Show
GSE74704	XPO5	57510	3	0	17	Show
TCGA	XPO5	57510	20	12	64	Show

Total number of gains: 73; Total number of losses: 32; Total Number of normals: 383.  Download Data

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Somatic mutations of XPO5:

 

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Highly correlated genes for XPO5:

 

Showing top 20/1828 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
XPO5	GMNN	0.824247	7	0	7
XPO5	KIF20A	0.793595	6	0	6
XPO5	MELK	0.787502	6	0	6
XPO5	TMEM216	0.784936	3	0	3
XPO5	CEP55	0.780403	6	0	6
XPO5	KIF23	0.772198	6	0	6
XPO5	DTL	0.764108	7	0	7
XPO5	AURKA	0.760751	6	0	6
XPO5	CKS1B	0.75468	8	0	8
XPO5	CDCA3	0.754331	6	0	6
XPO5	CCNA2	0.75359	6	0	6
XPO5	ILF2	0.753346	7	0	7
XPO5	KPNA2	0.752782	5	0	5
XPO5	UBE2T	0.748994	8	0	7
XPO5	BYSL	0.74787	9	0	8
XPO5	FANCI	0.747611	7	0	7
XPO5	CAD	0.747461	8	0	8
XPO5	PRKDC	0.745511	7	0	6
XPO5	NOP2	0.745318	8	0	8
XPO5	KNTC1	0.743847	7	0	7

For details and further investigation, click here