| Full name: endothelin receptor type A | Alias Symbol: ET-A|ETA-R|hET-AR | ||
| Type: protein-coding gene | Cytoband: 4q31.22-q31.23 | ||
| Entrez ID: 1909 | HGNC ID: HGNC:3179 | Ensembl Gene: ENSG00000151617 | OMIM ID: 131243 |
| Drug and gene relationship at DGIdb | |||
EDNRA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction | |
| hsa04924 | Renin secretion |
Expression of EDNRA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDNRA | 1909 | 204464_s_at | 0.5259 | 0.5107 | |
| GSE20347 | EDNRA | 1909 | 204464_s_at | 0.3845 | 0.1198 | |
| GSE23400 | EDNRA | 1909 | 216235_s_at | -0.0402 | 0.2656 | |
| GSE26886 | EDNRA | 1909 | 204464_s_at | -0.0062 | 0.9909 | |
| GSE29001 | EDNRA | 1909 | 204464_s_at | 0.2954 | 0.6452 | |
| GSE38129 | EDNRA | 1909 | 204464_s_at | 0.1014 | 0.7446 | |
| GSE45670 | EDNRA | 1909 | 204464_s_at | -0.3926 | 0.3813 | |
| GSE53622 | EDNRA | 1909 | 77824 | 0.8057 | 0.0000 | |
| GSE53624 | EDNRA | 1909 | 59751 | 0.5079 | 0.0000 | |
| GSE63941 | EDNRA | 1909 | 216235_s_at | -1.3452 | 0.0049 | |
| GSE77861 | EDNRA | 1909 | 216235_s_at | 0.0376 | 0.8687 | |
| GSE97050 | EDNRA | 1909 | A_24_P217572 | 0.5581 | 0.2931 | |
| SRP007169 | EDNRA | 1909 | RNAseq | 1.4055 | 0.0033 | |
| SRP008496 | EDNRA | 1909 | RNAseq | 1.6094 | 0.0000 | |
| SRP064894 | EDNRA | 1909 | RNAseq | 1.1282 | 0.0000 | |
| SRP133303 | EDNRA | 1909 | RNAseq | 0.6422 | 0.0387 | |
| SRP159526 | EDNRA | 1909 | RNAseq | 0.1998 | 0.6168 | |
| SRP193095 | EDNRA | 1909 | RNAseq | 0.8695 | 0.0009 | |
| SRP219564 | EDNRA | 1909 | RNAseq | 1.1607 | 0.0278 | |
| TCGA | EDNRA | 1909 | RNAseq | 0.2523 | 0.0567 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by EDNRA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDNRA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDNRA | 1909 | 0 | 12 | 18 | |
| GSE20123 | EDNRA | 1909 | 0 | 12 | 18 | |
| GSE43470 | EDNRA | 1909 | 0 | 13 | 30 | |
| GSE46452 | EDNRA | 1909 | 1 | 36 | 22 | |
| GSE47630 | EDNRA | 1909 | 0 | 22 | 18 | |
| GSE54993 | EDNRA | 1909 | 10 | 0 | 60 | |
| GSE54994 | EDNRA | 1909 | 2 | 11 | 40 | |
| GSE60625 | EDNRA | 1909 | 0 | 1 | 10 | |
| GSE74703 | EDNRA | 1909 | 0 | 11 | 25 | |
| GSE74704 | EDNRA | 1909 | 0 | 7 | 13 | |
| TCGA | EDNRA | 1909 | 12 | 32 | 52 |
Total number of gains: 25; Total number of losses: 157; Total Number of normals: 306.
Somatic mutations of EDNRA:
Generating mutation plots.
Highly correlated genes for EDNRA:
Showing top 20/224 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDNRA | GPX8 | 0.642111 | 7 | 0 | 6 |
| EDNRA | HSD17B2 | 0.639185 | 3 | 0 | 3 |
| EDNRA | CYB5R3 | 0.638348 | 4 | 0 | 4 |
| EDNRA | ROBO1 | 0.625172 | 3 | 0 | 3 |
| EDNRA | CDH11 | 0.623457 | 9 | 0 | 7 |
| EDNRA | EDEM3 | 0.620447 | 4 | 0 | 3 |
| EDNRA | FCRLB | 0.620185 | 3 | 0 | 3 |
| EDNRA | SIL1 | 0.616539 | 3 | 0 | 3 |
| EDNRA | TIE1 | 0.614142 | 5 | 0 | 4 |
| EDNRA | SH2D2A | 0.61169 | 5 | 0 | 4 |
| EDNRA | PAG1 | 0.609972 | 8 | 0 | 6 |
| EDNRA | OLFML2B | 0.609163 | 10 | 0 | 8 |
| EDNRA | CLEC11A | 0.60854 | 7 | 0 | 6 |
| EDNRA | PCOLCE | 0.607279 | 11 | 0 | 9 |
| EDNRA | COL6A3 | 0.607153 | 11 | 0 | 9 |
| EDNRA | NOX4 | 0.605799 | 10 | 0 | 9 |
| EDNRA | ABHD15 | 0.605745 | 3 | 0 | 3 |
| EDNRA | DACT1 | 0.605291 | 11 | 0 | 8 |
| EDNRA | TMEM200A | 0.60526 | 7 | 0 | 6 |
| EDNRA | VEGFC | 0.604359 | 8 | 0 | 6 |
For details and further investigation, click here
