EIF2S1

 

Full name: eukaryotic translation initiation factor 2 subunit alpha Alias Symbol: EIF-2alpha|EIF2A
Type: protein-coding gene Cytoband: 14q23.3
Entrez ID: 1965 HGNC ID: HGNC:3265 Ensembl Gene: ENSG00000134001 OMIM ID: 603907
Drug and gene relationship at DGIdb

 

EIF2S1 involved pathways:

KEGG pathway Description View
hsa04210Apoptosis
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa05160Hepatitis C
hsa05162Measles
hsa05164Influenza A
hsa05168Herpes simplex infection

 

Expression of EIF2S1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EIF2S1 1965 201144_s_at 0.3228 0.4826
GSE20347 EIF2S1 1965 201144_s_at 0.3016 0.0670
GSE23400 EIF2S1 1965 201144_s_at 0.5862 0.0000
GSE26886 EIF2S1 1965 201144_s_at 0.0703 0.8140
GSE29001 EIF2S1 1965 201144_s_at 0.2991 0.5090
GSE38129 EIF2S1 1965 201144_s_at 0.4112 0.0031
GSE45670 EIF2S1 1965 201144_s_at 0.6361 0.0009
GSE53622 EIF2S1 1965 56760 0.0192 0.8896
GSE53624 EIF2S1 1965 56760 0.3418 0.0003
GSE63941 EIF2S1 1965 201144_s_at 1.2067 0.0005
GSE77861 EIF2S1 1965 201144_s_at 0.2262 0.5731
GSE97050 EIF2S1 1965 A_33_P3402171 -0.0748 0.7778
SRP007169 EIF2S1 1965 RNAseq 0.3167 0.3314
SRP008496 EIF2S1 1965 RNAseq 0.3668 0.0317
SRP064894 EIF2S1 1965 RNAseq 0.3327 0.0463
SRP133303 EIF2S1 1965 RNAseq 0.6029 0.0008
SRP159526 EIF2S1 1965 RNAseq -0.0069 0.9851
SRP193095 EIF2S1 1965 RNAseq 0.1500 0.2767
SRP219564 EIF2S1 1965 RNAseq 0.2099 0.6056
TCGA EIF2S1 1965 RNAseq 0.1307 0.0069

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by EIF2S1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EIF2S1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EIF2S1 1965 7 3 20
GSE20123 EIF2S1 1965 7 3 20
GSE43470 EIF2S1 1965 8 2 33
GSE46452 EIF2S1 1965 16 3 40
GSE47630 EIF2S1 1965 11 9 20
GSE54993 EIF2S1 1965 3 9 58
GSE54994 EIF2S1 1965 18 5 30
GSE60625 EIF2S1 1965 0 2 9
GSE74703 EIF2S1 1965 7 2 27
GSE74704 EIF2S1 1965 3 2 15
TCGA EIF2S1 1965 34 14 48

Total number of gains: 114; Total number of losses: 54; Total Number of normals: 320.  

 

Somatic mutations of EIF2S1:

 

Generating mutation plots.

 

Highly correlated genes for EIF2S1:

 

Showing top 20/1171 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EIF2S1NUS10.772184404
EIF2S1C12orf450.753007303
EIF2S1OTUD6B0.74957303
EIF2S1PSMC10.74497211011
EIF2S1SMARCA50.741111303
EIF2S1MED60.740623909
EIF2S1TMEM167A0.737029404
EIF2S1HELB0.733963303
EIF2S1DYRK20.727684303
EIF2S1CLDND10.724312303
EIF2S1CHMP1B0.721864303
EIF2S1ISCA20.714638807
EIF2S1EPB41L50.710944303
EIF2S1RLIM0.709836303
EIF2S1SLC45A40.706253404
EIF2S1MZT10.70421403
EIF2S1GEMIN50.703907404
EIF2S1ZBTB90.70312303
EIF2S1FMNL20.70278303
EIF2S1AMMECR1L0.70053303

For details and further investigation, click here