| Full name: OTU deubiquitinase 6B | Alias Symbol: CGI-77|DUBA5 | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 51633 | HGNC ID: HGNC:24281 | Ensembl Gene: ENSG00000155100 | OMIM ID: 612021 |
| Drug and gene relationship at DGIdb | |||
Expression of OTUD6B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OTUD6B | 51633 | 222825_at | 0.8296 | 0.2365 | |
| GSE26886 | OTUD6B | 51633 | 222825_at | -0.1341 | 0.6394 | |
| GSE45670 | OTUD6B | 51633 | 222825_at | 0.3698 | 0.0245 | |
| GSE53622 | OTUD6B | 51633 | 48723 | 0.4640 | 0.0000 | |
| GSE53624 | OTUD6B | 51633 | 48723 | 0.5552 | 0.0000 | |
| GSE63941 | OTUD6B | 51633 | 222825_at | 0.3397 | 0.6473 | |
| GSE77861 | OTUD6B | 51633 | 222825_at | 0.1411 | 0.6689 | |
| GSE97050 | OTUD6B | 51633 | A_23_P111929 | 0.2170 | 0.4369 | |
| SRP007169 | OTUD6B | 51633 | RNAseq | 1.1989 | 0.0508 | |
| SRP008496 | OTUD6B | 51633 | RNAseq | 1.7622 | 0.0002 | |
| SRP064894 | OTUD6B | 51633 | RNAseq | 0.4670 | 0.1010 | |
| SRP133303 | OTUD6B | 51633 | RNAseq | 0.5955 | 0.0012 | |
| SRP159526 | OTUD6B | 51633 | RNAseq | 0.1573 | 0.6987 | |
| SRP193095 | OTUD6B | 51633 | RNAseq | 0.1126 | 0.3404 | |
| SRP219564 | OTUD6B | 51633 | RNAseq | 0.3041 | 0.4369 | |
| TCGA | OTUD6B | 51633 | RNAseq | 0.2363 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by OTUD6B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OTUD6B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OTUD6B | 51633 | 14 | 1 | 15 | |
| GSE20123 | OTUD6B | 51633 | 15 | 1 | 14 | |
| GSE43470 | OTUD6B | 51633 | 20 | 1 | 22 | |
| GSE46452 | OTUD6B | 51633 | 22 | 0 | 37 | |
| GSE47630 | OTUD6B | 51633 | 24 | 0 | 16 | |
| GSE54993 | OTUD6B | 51633 | 0 | 20 | 50 | |
| GSE54994 | OTUD6B | 51633 | 33 | 1 | 19 | |
| GSE60625 | OTUD6B | 51633 | 0 | 4 | 7 | |
| GSE74703 | OTUD6B | 51633 | 17 | 1 | 18 | |
| GSE74704 | OTUD6B | 51633 | 10 | 0 | 10 | |
| TCGA | OTUD6B | 51633 | 56 | 1 | 39 |
Total number of gains: 211; Total number of losses: 30; Total Number of normals: 247.
Somatic mutations of OTUD6B:
Generating mutation plots.
Highly correlated genes for OTUD6B:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OTUD6B | MLEC | 0.830567 | 3 | 0 | 3 |
| OTUD6B | SLC45A4 | 0.776286 | 3 | 0 | 3 |
| OTUD6B | CBFA2T2 | 0.776271 | 3 | 0 | 3 |
| OTUD6B | GLRX5 | 0.754897 | 3 | 0 | 3 |
| OTUD6B | EIF2S1 | 0.74957 | 3 | 0 | 3 |
| OTUD6B | CCP110 | 0.745043 | 3 | 0 | 3 |
| OTUD6B | LYSMD1 | 0.743706 | 3 | 0 | 3 |
| OTUD6B | B3GALT6 | 0.731096 | 4 | 0 | 3 |
| OTUD6B | MRPS28 | 0.730537 | 4 | 0 | 4 |
| OTUD6B | MCMBP | 0.729706 | 3 | 0 | 3 |
| OTUD6B | GBP1 | 0.726866 | 3 | 0 | 3 |
| OTUD6B | POLR2K | 0.726552 | 5 | 0 | 4 |
| OTUD6B | SLC7A6OS | 0.724871 | 3 | 0 | 3 |
| OTUD6B | ZMYND19 | 0.723227 | 3 | 0 | 3 |
| OTUD6B | RRP36 | 0.721277 | 3 | 0 | 3 |
| OTUD6B | NIPBL | 0.718095 | 3 | 0 | 3 |
| OTUD6B | MTERF3 | 0.7147 | 4 | 0 | 4 |
| OTUD6B | EMG1 | 0.71431 | 3 | 0 | 3 |
| OTUD6B | CXCL5 | 0.704112 | 3 | 0 | 3 |
| OTUD6B | TAF2 | 0.703899 | 7 | 0 | 6 |
For details and further investigation, click here
