| Full name: mediator complex subunit 6 | Alias Symbol: NY-REN-28 | ||
| Type: protein-coding gene | Cytoband: 14q24.2 | ||
| Entrez ID: 10001 | HGNC ID: HGNC:19970 | Ensembl Gene: ENSG00000133997 | OMIM ID: 602984 |
| Drug and gene relationship at DGIdb | |||
Expression of MED6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED6 | 10001 | 210104_at | 0.0345 | 0.9676 | |
| GSE20347 | MED6 | 10001 | 210104_at | 0.0309 | 0.8981 | |
| GSE23400 | MED6 | 10001 | 210104_at | 0.2243 | 0.0003 | |
| GSE26886 | MED6 | 10001 | 210104_at | -0.4316 | 0.1079 | |
| GSE29001 | MED6 | 10001 | 207078_at | 0.3976 | 0.1287 | |
| GSE38129 | MED6 | 10001 | 210104_at | 0.3063 | 0.0703 | |
| GSE45670 | MED6 | 10001 | 210104_at | 0.2380 | 0.1545 | |
| GSE53622 | MED6 | 10001 | 95691 | 0.4427 | 0.0000 | |
| GSE53624 | MED6 | 10001 | 95691 | 0.1731 | 0.1196 | |
| GSE63941 | MED6 | 10001 | 210104_at | 1.3154 | 0.0011 | |
| GSE77861 | MED6 | 10001 | 210104_at | 0.0756 | 0.8842 | |
| GSE97050 | MED6 | 10001 | A_23_P54170 | 0.1578 | 0.6513 | |
| SRP007169 | MED6 | 10001 | RNAseq | -0.2208 | 0.5625 | |
| SRP008496 | MED6 | 10001 | RNAseq | -0.0720 | 0.7684 | |
| SRP064894 | MED6 | 10001 | RNAseq | 0.1707 | 0.2949 | |
| SRP133303 | MED6 | 10001 | RNAseq | 0.1618 | 0.2029 | |
| SRP159526 | MED6 | 10001 | RNAseq | 0.0450 | 0.8628 | |
| SRP193095 | MED6 | 10001 | RNAseq | -0.1129 | 0.3441 | |
| SRP219564 | MED6 | 10001 | RNAseq | 0.0977 | 0.7716 | |
| TCGA | MED6 | 10001 | RNAseq | 0.2184 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MED6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED6 | 10001 | 8 | 3 | 19 | |
| GSE20123 | MED6 | 10001 | 8 | 3 | 19 | |
| GSE43470 | MED6 | 10001 | 8 | 3 | 32 | |
| GSE46452 | MED6 | 10001 | 16 | 3 | 40 | |
| GSE47630 | MED6 | 10001 | 11 | 9 | 20 | |
| GSE54993 | MED6 | 10001 | 3 | 9 | 58 | |
| GSE54994 | MED6 | 10001 | 18 | 5 | 30 | |
| GSE60625 | MED6 | 10001 | 0 | 2 | 9 | |
| GSE74703 | MED6 | 10001 | 7 | 3 | 26 | |
| GSE74704 | MED6 | 10001 | 3 | 3 | 14 | |
| TCGA | MED6 | 10001 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of MED6:
Generating mutation plots.
Highly correlated genes for MED6:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED6 | EIF2S1 | 0.740623 | 9 | 0 | 9 |
| MED6 | ISCA2 | 0.73651 | 6 | 0 | 6 |
| MED6 | PSMD6 | 0.684943 | 3 | 0 | 3 |
| MED6 | JKAMP | 0.678312 | 5 | 0 | 5 |
| MED6 | SNW1 | 0.670103 | 9 | 0 | 7 |
| MED6 | PTP4A1 | 0.654106 | 4 | 0 | 3 |
| MED6 | STYX | 0.650675 | 5 | 0 | 5 |
| MED6 | GOLGA5 | 0.649302 | 8 | 0 | 7 |
| MED6 | MARK3 | 0.648517 | 10 | 0 | 9 |
| MED6 | SLIRP | 0.648028 | 9 | 0 | 8 |
| MED6 | RDH11 | 0.636651 | 11 | 0 | 9 |
| MED6 | CNIH1 | 0.634822 | 9 | 0 | 8 |
| MED6 | TMEM167A | 0.631444 | 4 | 0 | 3 |
| MED6 | CHURC1 | 0.628526 | 6 | 0 | 4 |
| MED6 | DMKN | 0.624113 | 4 | 0 | 3 |
| MED6 | C14orf119 | 0.621405 | 4 | 0 | 4 |
| MED6 | SNRNP200 | 0.619299 | 3 | 0 | 3 |
| MED6 | FCF1 | 0.614574 | 7 | 0 | 4 |
| MED6 | XRCC3 | 0.614062 | 3 | 0 | 3 |
| MED6 | EXOC5 | 0.612042 | 8 | 0 | 8 |
For details and further investigation, click here
