HELB

 

Full name: DNA helicase B Alias Symbol: 
Type: protein-coding gene Cytoband: 12q14.3
Entrez ID: 92797 HGNC ID: HGNC:17196 Ensembl Gene: ENSG00000127311 OMIM ID: 614539
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of HELB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HELB 92797 1552788_a_at 0.2004 0.4236
GSE26886 HELB 92797 1552788_a_at -0.0658 0.4824
GSE45670 HELB 92797 1570200_at 0.0685 0.3580
GSE53622 HELB 92797 114795 0.8111 0.0000
GSE53624 HELB 92797 38882 0.2886 0.0310
GSE63941 HELB 92797 1552788_a_at 0.4545 0.0784
GSE77861 HELB 92797 1552788_a_at -0.0478 0.6168
GSE97050 HELB 92797 A_23_P2294 0.2984 0.4233
SRP007169 HELB 92797 RNAseq 1.7628 0.0064
SRP133303 HELB 92797 RNAseq 0.5350 0.0001
SRP159526 HELB 92797 RNAseq 1.6044 0.0067
SRP193095 HELB 92797 RNAseq 0.5561 0.0016
TCGA HELB 92797 RNAseq 0.1002 0.4522

Upregulated datasets: 2; Downregulated datasets: 0.  


 

Survival by HELB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of HELB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HELB 92797 5 1 24
GSE20123 HELB 92797 5 1 24
GSE43470 HELB 92797 5 0 38
GSE46452 HELB 92797 13 0 46
GSE47630 HELB 92797 10 1 29
GSE54993 HELB 92797 0 7 63
GSE54994 HELB 92797 6 1 46
GSE60625 HELB 92797 0 0 11
GSE74703 HELB 92797 5 0 31
GSE74704 HELB 92797 4 1 15
TCGA HELB 92797 24 9 63

Total number of gains: 77; Total number of losses: 21; Total Number of normals: 390.  


 

Somatic mutations of HELB:

 

Generating mutation plots.

 

Highly correlated genes for HELB:

 

Showing top 20/232 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HELBC17orf750.783022303
HELBBCL2A10.780975303
HELBANGPT20.773156303
HELBDHODH0.75769303
HELBPPP5C0.749332303
HELBPOFUT10.74058303
HELBADA0.737243303
HELBEIF2S10.733963303
HELBDERL10.732001303
HELBARPC1B0.731481303
HELBPSTPIP20.73036303
HELBTDO20.730173303
HELBSLC11A10.725066303
HELBCEBPB0.721385303
HELBGPR190.716744303
HELBSLC7A6OS0.71334303
HELBSLC36A40.7125303
HELBOSCAR0.712434303
HELBTEAD40.711242303
HELBPDAP10.70708303

For details and further investigation, click here