| Full name: DNA helicase B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q14.3 | ||
| Entrez ID: 92797 | HGNC ID: HGNC:17196 | Ensembl Gene: ENSG00000127311 | OMIM ID: 614539 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HELB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HELB | 92797 | 1552788_a_at | 0.2004 | 0.4236 | |
| GSE26886 | HELB | 92797 | 1552788_a_at | -0.0658 | 0.4824 | |
| GSE45670 | HELB | 92797 | 1570200_at | 0.0685 | 0.3580 | |
| GSE53622 | HELB | 92797 | 114795 | 0.8111 | 0.0000 | |
| GSE53624 | HELB | 92797 | 38882 | 0.2886 | 0.0310 | |
| GSE63941 | HELB | 92797 | 1552788_a_at | 0.4545 | 0.0784 | |
| GSE77861 | HELB | 92797 | 1552788_a_at | -0.0478 | 0.6168 | |
| GSE97050 | HELB | 92797 | A_23_P2294 | 0.2984 | 0.4233 | |
| SRP007169 | HELB | 92797 | RNAseq | 1.7628 | 0.0064 | |
| SRP133303 | HELB | 92797 | RNAseq | 0.5350 | 0.0001 | |
| SRP159526 | HELB | 92797 | RNAseq | 1.6044 | 0.0067 | |
| SRP193095 | HELB | 92797 | RNAseq | 0.5561 | 0.0016 | |
| TCGA | HELB | 92797 | RNAseq | 0.1002 | 0.4522 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HELB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HELB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HELB | 92797 | 5 | 1 | 24 | |
| GSE20123 | HELB | 92797 | 5 | 1 | 24 | |
| GSE43470 | HELB | 92797 | 5 | 0 | 38 | |
| GSE46452 | HELB | 92797 | 13 | 0 | 46 | |
| GSE47630 | HELB | 92797 | 10 | 1 | 29 | |
| GSE54993 | HELB | 92797 | 0 | 7 | 63 | |
| GSE54994 | HELB | 92797 | 6 | 1 | 46 | |
| GSE60625 | HELB | 92797 | 0 | 0 | 11 | |
| GSE74703 | HELB | 92797 | 5 | 0 | 31 | |
| GSE74704 | HELB | 92797 | 4 | 1 | 15 | |
| TCGA | HELB | 92797 | 24 | 9 | 63 |
Total number of gains: 77; Total number of losses: 21; Total Number of normals: 390.
Somatic mutations of HELB:
Generating mutation plots.
Highly correlated genes for HELB:
Showing top 20/232 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HELB | C17orf75 | 0.783022 | 3 | 0 | 3 |
| HELB | BCL2A1 | 0.780975 | 3 | 0 | 3 |
| HELB | ANGPT2 | 0.773156 | 3 | 0 | 3 |
| HELB | DHODH | 0.75769 | 3 | 0 | 3 |
| HELB | PPP5C | 0.749332 | 3 | 0 | 3 |
| HELB | POFUT1 | 0.74058 | 3 | 0 | 3 |
| HELB | ADA | 0.737243 | 3 | 0 | 3 |
| HELB | EIF2S1 | 0.733963 | 3 | 0 | 3 |
| HELB | DERL1 | 0.732001 | 3 | 0 | 3 |
| HELB | ARPC1B | 0.731481 | 3 | 0 | 3 |
| HELB | PSTPIP2 | 0.73036 | 3 | 0 | 3 |
| HELB | TDO2 | 0.730173 | 3 | 0 | 3 |
| HELB | SLC11A1 | 0.725066 | 3 | 0 | 3 |
| HELB | CEBPB | 0.721385 | 3 | 0 | 3 |
| HELB | GPR19 | 0.716744 | 3 | 0 | 3 |
| HELB | SLC7A6OS | 0.71334 | 3 | 0 | 3 |
| HELB | SLC36A4 | 0.7125 | 3 | 0 | 3 |
| HELB | OSCAR | 0.712434 | 3 | 0 | 3 |
| HELB | TEAD4 | 0.711242 | 3 | 0 | 3 |
| HELB | PDAP1 | 0.70708 | 3 | 0 | 3 |
For details and further investigation, click here
