| Full name: iron-sulfur cluster assembly 2 | Alias Symbol: ISA2 | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 122961 | HGNC ID: HGNC:19857 | Ensembl Gene: ENSG00000165898 | OMIM ID: 615317 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ISCA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISCA2 | 122961 | 226007_at | 0.2788 | 0.4804 | |
| GSE26886 | ISCA2 | 122961 | 226007_at | 0.2582 | 0.2644 | |
| GSE45670 | ISCA2 | 122961 | 226007_at | 0.3253 | 0.0559 | |
| GSE53622 | ISCA2 | 122961 | 44216 | 0.2417 | 0.0146 | |
| GSE53624 | ISCA2 | 122961 | 44216 | 0.4544 | 0.0000 | |
| GSE63941 | ISCA2 | 122961 | 226007_at | 0.7728 | 0.0797 | |
| GSE77861 | ISCA2 | 122961 | 226007_at | 0.2035 | 0.6216 | |
| GSE97050 | ISCA2 | 122961 | A_23_P151746 | 0.0230 | 0.9471 | |
| SRP007169 | ISCA2 | 122961 | RNAseq | -0.0004 | 0.9992 | |
| SRP008496 | ISCA2 | 122961 | RNAseq | -0.0996 | 0.6854 | |
| SRP064894 | ISCA2 | 122961 | RNAseq | 0.4199 | 0.0829 | |
| SRP133303 | ISCA2 | 122961 | RNAseq | 0.2885 | 0.0263 | |
| SRP159526 | ISCA2 | 122961 | RNAseq | 0.2763 | 0.3757 | |
| SRP193095 | ISCA2 | 122961 | RNAseq | -0.0549 | 0.7009 | |
| SRP219564 | ISCA2 | 122961 | RNAseq | 0.3580 | 0.3634 | |
| TCGA | ISCA2 | 122961 | RNAseq | 0.0789 | 0.2182 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ISCA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISCA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISCA2 | 122961 | 8 | 3 | 19 | |
| GSE20123 | ISCA2 | 122961 | 8 | 3 | 19 | |
| GSE43470 | ISCA2 | 122961 | 8 | 3 | 32 | |
| GSE46452 | ISCA2 | 122961 | 16 | 3 | 40 | |
| GSE47630 | ISCA2 | 122961 | 11 | 8 | 21 | |
| GSE54993 | ISCA2 | 122961 | 3 | 8 | 59 | |
| GSE54994 | ISCA2 | 122961 | 19 | 4 | 30 | |
| GSE60625 | ISCA2 | 122961 | 0 | 2 | 9 | |
| GSE74703 | ISCA2 | 122961 | 7 | 3 | 26 | |
| GSE74704 | ISCA2 | 122961 | 3 | 3 | 14 | |
| TCGA | ISCA2 | 122961 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of ISCA2:
Generating mutation plots.
Highly correlated genes for ISCA2:
Showing top 20/714 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISCA2 | CYCS | 0.804622 | 3 | 0 | 3 |
| ISCA2 | MZT1 | 0.788864 | 3 | 0 | 3 |
| ISCA2 | RAB13 | 0.766815 | 3 | 0 | 3 |
| ISCA2 | SIVA1 | 0.757409 | 6 | 0 | 6 |
| ISCA2 | TCERG1 | 0.745508 | 3 | 0 | 3 |
| ISCA2 | COPA | 0.744309 | 3 | 0 | 3 |
| ISCA2 | MGAT2 | 0.740906 | 6 | 0 | 6 |
| ISCA2 | MED6 | 0.73651 | 6 | 0 | 6 |
| ISCA2 | NIT2 | 0.728156 | 3 | 0 | 3 |
| ISCA2 | MTIF2 | 0.724415 | 3 | 0 | 3 |
| ISCA2 | ARL15 | 0.724144 | 3 | 0 | 3 |
| ISCA2 | ALKBH1 | 0.724098 | 7 | 0 | 7 |
| ISCA2 | TP53RK | 0.723063 | 3 | 0 | 3 |
| ISCA2 | GOLGA5 | 0.718905 | 6 | 0 | 5 |
| ISCA2 | JKAMP | 0.718288 | 7 | 0 | 6 |
| ISCA2 | AP1S3 | 0.717818 | 3 | 0 | 3 |
| ISCA2 | EIF2S1 | 0.714638 | 8 | 0 | 7 |
| ISCA2 | MTHFD1 | 0.710579 | 9 | 0 | 9 |
| ISCA2 | NEK11 | 0.709696 | 3 | 0 | 3 |
| ISCA2 | DSTYK | 0.708935 | 3 | 0 | 3 |
For details and further investigation, click here
