| Full name: charged multivesicular body protein 1B | Alias Symbol: CHMP1.5|C18orf2|Vps46B | ||
| Type: protein-coding gene | Cytoband: 18p11.21 | ||
| Entrez ID: 57132 | HGNC ID: HGNC:24287 | Ensembl Gene: ENSG00000255112 | OMIM ID: 606486 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CHMP1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHMP1B | 57132 | 218178_s_at | 0.0746 | 0.9377 | |
| GSE20347 | CHMP1B | 57132 | 218178_s_at | -0.0398 | 0.8106 | |
| GSE23400 | CHMP1B | 57132 | 218178_s_at | -0.0310 | 0.6600 | |
| GSE26886 | CHMP1B | 57132 | 218178_s_at | -0.9966 | 0.0000 | |
| GSE29001 | CHMP1B | 57132 | 218178_s_at | -0.0636 | 0.7855 | |
| GSE38129 | CHMP1B | 57132 | 218178_s_at | 0.2222 | 0.1914 | |
| GSE45670 | CHMP1B | 57132 | 218178_s_at | -0.0564 | 0.7773 | |
| GSE53622 | CHMP1B | 57132 | 49139 | -0.7508 | 0.0000 | |
| GSE53624 | CHMP1B | 57132 | 49139 | -0.4044 | 0.0000 | |
| GSE63941 | CHMP1B | 57132 | 218178_s_at | 0.3710 | 0.5569 | |
| GSE77861 | CHMP1B | 57132 | 218178_s_at | 0.1529 | 0.5311 | |
| GSE97050 | CHMP1B | 57132 | A_33_P3276475 | -0.2547 | 0.3654 | |
| SRP007169 | CHMP1B | 57132 | RNAseq | -0.9906 | 0.0102 | |
| SRP008496 | CHMP1B | 57132 | RNAseq | -0.7583 | 0.0001 | |
| SRP064894 | CHMP1B | 57132 | RNAseq | -0.2578 | 0.2881 | |
| SRP133303 | CHMP1B | 57132 | RNAseq | 0.4240 | 0.1204 | |
| SRP159526 | CHMP1B | 57132 | RNAseq | 0.2610 | 0.5220 | |
| SRP193095 | CHMP1B | 57132 | RNAseq | 0.0474 | 0.7538 | |
| SRP219564 | CHMP1B | 57132 | RNAseq | 0.0630 | 0.8246 | |
| TCGA | CHMP1B | 57132 | RNAseq | 0.0186 | 0.6994 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHMP1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHMP1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHMP1B | 57132 | 5 | 3 | 22 | |
| GSE20123 | CHMP1B | 57132 | 5 | 3 | 22 | |
| GSE43470 | CHMP1B | 57132 | 1 | 6 | 36 | |
| GSE46452 | CHMP1B | 57132 | 3 | 21 | 35 | |
| GSE47630 | CHMP1B | 57132 | 7 | 17 | 16 | |
| GSE54993 | CHMP1B | 57132 | 6 | 2 | 62 | |
| GSE54994 | CHMP1B | 57132 | 8 | 8 | 37 | |
| GSE60625 | CHMP1B | 57132 | 0 | 4 | 7 | |
| GSE74703 | CHMP1B | 57132 | 1 | 4 | 31 | |
| GSE74704 | CHMP1B | 57132 | 3 | 2 | 15 | |
| TCGA | CHMP1B | 57132 | 29 | 22 | 45 |
Total number of gains: 68; Total number of losses: 92; Total Number of normals: 328.
Somatic mutations of CHMP1B:
Generating mutation plots.
Highly correlated genes for CHMP1B:
Showing top 20/258 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHMP1B | RMND5B | 0.746527 | 3 | 0 | 3 |
| CHMP1B | TOM1 | 0.734755 | 3 | 0 | 3 |
| CHMP1B | WASF2 | 0.726645 | 3 | 0 | 3 |
| CHMP1B | PLK2 | 0.7252 | 3 | 0 | 3 |
| CHMP1B | EIF2S1 | 0.721864 | 3 | 0 | 3 |
| CHMP1B | S1PR5 | 0.719524 | 3 | 0 | 3 |
| CHMP1B | RNF185 | 0.716995 | 3 | 0 | 3 |
| CHMP1B | SCAMP2 | 0.716835 | 3 | 0 | 3 |
| CHMP1B | RNF139 | 0.710823 | 3 | 0 | 3 |
| CHMP1B | CPPED1 | 0.709408 | 4 | 0 | 3 |
| CHMP1B | AKIRIN2 | 0.704684 | 3 | 0 | 3 |
| CHMP1B | MT1X | 0.702451 | 3 | 0 | 3 |
| CHMP1B | KHNYN | 0.697983 | 4 | 0 | 3 |
| CHMP1B | NAP1L4 | 0.697732 | 3 | 0 | 3 |
| CHMP1B | VTI1B | 0.691293 | 3 | 0 | 3 |
| CHMP1B | RHBDF1 | 0.689253 | 3 | 0 | 3 |
| CHMP1B | PNMA1 | 0.6864 | 3 | 0 | 3 |
| CHMP1B | TOM1L2 | 0.683672 | 3 | 0 | 3 |
| CHMP1B | CLTB | 0.68209 | 4 | 0 | 3 |
| CHMP1B | VAPA | 0.680064 | 9 | 0 | 9 |
For details and further investigation, click here
