| Full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | Alias Symbol: hSNF2H|hISWI|ISWI | ||
| Type: protein-coding gene | Cytoband: 4q31.21 | ||
| Entrez ID: 8467 | HGNC ID: HGNC:11101 | Ensembl Gene: ENSG00000153147 | OMIM ID: 603375 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SMARCA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMARCA5 | 8467 | 213251_at | 0.1538 | 0.7555 | |
| GSE20347 | SMARCA5 | 8467 | 213251_at | 0.1376 | 0.4629 | |
| GSE23400 | SMARCA5 | 8467 | 202303_x_at | 0.5475 | 0.0000 | |
| GSE26886 | SMARCA5 | 8467 | 213251_at | 0.6249 | 0.0092 | |
| GSE29001 | SMARCA5 | 8467 | 213251_at | 0.2241 | 0.6515 | |
| GSE38129 | SMARCA5 | 8467 | 213251_at | 0.0007 | 0.9971 | |
| GSE45670 | SMARCA5 | 8467 | 213251_at | -0.1126 | 0.4285 | |
| GSE53622 | SMARCA5 | 8467 | 29563 | 0.5374 | 0.0000 | |
| GSE53624 | SMARCA5 | 8467 | 29563 | 0.5736 | 0.0000 | |
| GSE63941 | SMARCA5 | 8467 | 202303_x_at | -0.2746 | 0.3386 | |
| GSE77861 | SMARCA5 | 8467 | 213251_at | 0.6270 | 0.0258 | |
| GSE97050 | SMARCA5 | 8467 | A_23_P256716 | 0.2474 | 0.4765 | |
| SRP007169 | SMARCA5 | 8467 | RNAseq | 1.3867 | 0.0009 | |
| SRP008496 | SMARCA5 | 8467 | RNAseq | 1.6323 | 0.0000 | |
| SRP064894 | SMARCA5 | 8467 | RNAseq | 0.2989 | 0.0597 | |
| SRP133303 | SMARCA5 | 8467 | RNAseq | 0.6053 | 0.0000 | |
| SRP159526 | SMARCA5 | 8467 | RNAseq | 0.4695 | 0.0013 | |
| SRP193095 | SMARCA5 | 8467 | RNAseq | 0.2773 | 0.0032 | |
| SRP219564 | SMARCA5 | 8467 | RNAseq | -0.0291 | 0.9439 | |
| TCGA | SMARCA5 | 8467 | RNAseq | 0.0271 | 0.5419 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SMARCA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMARCA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMARCA5 | 8467 | 0 | 12 | 18 | |
| GSE20123 | SMARCA5 | 8467 | 0 | 12 | 18 | |
| GSE43470 | SMARCA5 | 8467 | 2 | 11 | 30 | |
| GSE46452 | SMARCA5 | 8467 | 1 | 36 | 22 | |
| GSE47630 | SMARCA5 | 8467 | 0 | 22 | 18 | |
| GSE54993 | SMARCA5 | 8467 | 10 | 0 | 60 | |
| GSE54994 | SMARCA5 | 8467 | 2 | 11 | 40 | |
| GSE60625 | SMARCA5 | 8467 | 0 | 1 | 10 | |
| GSE74703 | SMARCA5 | 8467 | 1 | 10 | 25 | |
| GSE74704 | SMARCA5 | 8467 | 0 | 6 | 14 | |
| TCGA | SMARCA5 | 8467 | 13 | 30 | 53 |
Total number of gains: 29; Total number of losses: 151; Total Number of normals: 308.
Somatic mutations of SMARCA5:
Generating mutation plots.
Highly correlated genes for SMARCA5:
Showing top 20/1475 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMARCA5 | LY75 | 0.794353 | 3 | 0 | 3 |
| SMARCA5 | MAPK9 | 0.788799 | 3 | 0 | 3 |
| SMARCA5 | COMMD3 | 0.769843 | 3 | 0 | 3 |
| SMARCA5 | C12orf45 | 0.766126 | 3 | 0 | 3 |
| SMARCA5 | STX16 | 0.765157 | 3 | 0 | 3 |
| SMARCA5 | SPPL2A | 0.753741 | 3 | 0 | 3 |
| SMARCA5 | MFF | 0.751554 | 4 | 0 | 4 |
| SMARCA5 | FCGR3A | 0.750842 | 3 | 0 | 3 |
| SMARCA5 | USP3 | 0.748908 | 3 | 0 | 3 |
| SMARCA5 | ALG10 | 0.742584 | 4 | 0 | 4 |
| SMARCA5 | RAD21 | 0.742141 | 5 | 0 | 5 |
| SMARCA5 | FZD6 | 0.741669 | 5 | 0 | 5 |
| SMARCA5 | EIF2S1 | 0.741111 | 3 | 0 | 3 |
| SMARCA5 | DNAAF2 | 0.735792 | 3 | 0 | 3 |
| SMARCA5 | SWT1 | 0.733429 | 3 | 0 | 3 |
| SMARCA5 | UBR7 | 0.731495 | 3 | 0 | 3 |
| SMARCA5 | CEP95 | 0.730681 | 3 | 0 | 3 |
| SMARCA5 | PARP8 | 0.728078 | 3 | 0 | 3 |
| SMARCA5 | FIGN | 0.726861 | 3 | 0 | 3 |
| SMARCA5 | CCT5 | 0.723551 | 3 | 0 | 3 |
For details and further investigation, click here
