| Full name: EWS RNA binding protein 1 | Alias Symbol: EWS | ||
| Type: protein-coding gene | Cytoband: 22q12.2 | ||
| Entrez ID: 2130 | HGNC ID: HGNC:3508 | Ensembl Gene: ENSG00000182944 | OMIM ID: 133450 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EWSR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EWSR1 | 2130 | 209214_s_at | 0.2651 | 0.2826 | |
| GSE20347 | EWSR1 | 2130 | 209214_s_at | 0.2122 | 0.0221 | |
| GSE23400 | EWSR1 | 2130 | 209214_s_at | 0.3611 | 0.0000 | |
| GSE26886 | EWSR1 | 2130 | 209214_s_at | 0.1703 | 0.2688 | |
| GSE29001 | EWSR1 | 2130 | 209214_s_at | 0.1043 | 0.4974 | |
| GSE38129 | EWSR1 | 2130 | 209214_s_at | 0.2286 | 0.0121 | |
| GSE45670 | EWSR1 | 2130 | 209214_s_at | 0.2410 | 0.0046 | |
| GSE53622 | EWSR1 | 2130 | 126927 | 0.2847 | 0.0000 | |
| GSE53624 | EWSR1 | 2130 | 126927 | 0.2216 | 0.0015 | |
| GSE63941 | EWSR1 | 2130 | 209214_s_at | 0.3854 | 0.0868 | |
| GSE77861 | EWSR1 | 2130 | 209214_s_at | 0.3088 | 0.0431 | |
| GSE97050 | EWSR1 | 2130 | A_23_P91657 | 0.1667 | 0.4596 | |
| SRP007169 | EWSR1 | 2130 | RNAseq | 0.4642 | 0.2051 | |
| SRP008496 | EWSR1 | 2130 | RNAseq | 0.4726 | 0.0146 | |
| SRP064894 | EWSR1 | 2130 | RNAseq | 0.4583 | 0.0002 | |
| SRP133303 | EWSR1 | 2130 | RNAseq | 0.2611 | 0.0597 | |
| SRP159526 | EWSR1 | 2130 | RNAseq | 0.3534 | 0.0408 | |
| SRP193095 | EWSR1 | 2130 | RNAseq | 0.2067 | 0.0162 | |
| SRP219564 | EWSR1 | 2130 | RNAseq | 0.2669 | 0.3099 | |
| TCGA | EWSR1 | 2130 | RNAseq | 0.0409 | 0.3054 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EWSR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EWSR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EWSR1 | 2130 | 3 | 5 | 22 | |
| GSE20123 | EWSR1 | 2130 | 3 | 4 | 23 | |
| GSE43470 | EWSR1 | 2130 | 4 | 5 | 34 | |
| GSE46452 | EWSR1 | 2130 | 31 | 1 | 27 | |
| GSE47630 | EWSR1 | 2130 | 8 | 5 | 27 | |
| GSE54993 | EWSR1 | 2130 | 3 | 6 | 61 | |
| GSE54994 | EWSR1 | 2130 | 11 | 8 | 34 | |
| GSE60625 | EWSR1 | 2130 | 5 | 0 | 6 | |
| GSE74703 | EWSR1 | 2130 | 4 | 4 | 28 | |
| GSE74704 | EWSR1 | 2130 | 0 | 1 | 19 | |
| TCGA | EWSR1 | 2130 | 26 | 16 | 54 |
Total number of gains: 98; Total number of losses: 55; Total Number of normals: 335.
Somatic mutations of EWSR1:
Generating mutation plots.
Highly correlated genes for EWSR1:
Showing top 20/1239 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EWSR1 | GLRX2 | 0.832386 | 3 | 0 | 3 |
| EWSR1 | ZNF317 | 0.823513 | 3 | 0 | 3 |
| EWSR1 | MRPL14 | 0.743248 | 3 | 0 | 3 |
| EWSR1 | ISY1 | 0.736598 | 3 | 0 | 3 |
| EWSR1 | TMEM237 | 0.72924 | 4 | 0 | 3 |
| EWSR1 | C1orf226 | 0.725087 | 3 | 0 | 3 |
| EWSR1 | LRRC58 | 0.719526 | 4 | 0 | 4 |
| EWSR1 | MIF | 0.719241 | 3 | 0 | 3 |
| EWSR1 | MID1IP1 | 0.710417 | 3 | 0 | 3 |
| EWSR1 | TMEM17 | 0.709641 | 3 | 0 | 3 |
| EWSR1 | GORAB | 0.709146 | 5 | 0 | 5 |
| EWSR1 | BPHL | 0.707131 | 4 | 0 | 3 |
| EWSR1 | SSBP4 | 0.704208 | 4 | 0 | 3 |
| EWSR1 | LYSMD1 | 0.704128 | 3 | 0 | 3 |
| EWSR1 | SPNS1 | 0.702636 | 3 | 0 | 3 |
| EWSR1 | CPSF6 | 0.701564 | 8 | 0 | 7 |
| EWSR1 | C2orf69 | 0.70095 | 4 | 0 | 3 |
| EWSR1 | SLC37A3 | 0.697963 | 3 | 0 | 3 |
| EWSR1 | NFXL1 | 0.693865 | 3 | 0 | 3 |
| EWSR1 | MSTO1 | 0.692482 | 5 | 0 | 4 |
For details and further investigation, click here
