| Full name: ISY1 splicing factor homolog | Alias Symbol: KIAA1160|fSAP33 | ||
| Type: protein-coding gene | Cytoband: 3q21.3 | ||
| Entrez ID: 57461 | HGNC ID: HGNC:29201 | Ensembl Gene: ENSG00000240682 | OMIM ID: 612764 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ISY1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISY1 | 57461 | 223831_x_at | 0.1493 | 0.5448 | |
| GSE26886 | ISY1 | 57461 | 223429_x_at | 0.0049 | 0.9819 | |
| GSE45670 | ISY1 | 57461 | 223429_x_at | 0.4006 | 0.0050 | |
| GSE63941 | ISY1 | 57461 | 223831_x_at | 0.5622 | 0.0738 | |
| GSE77861 | ISY1 | 57461 | 223831_x_at | 0.1052 | 0.6339 | |
| GSE97050 | ISY1 | 57461 | A_23_P124164 | 0.4357 | 0.2151 | |
| SRP007169 | ISY1 | 57461 | RNAseq | 1.8723 | 0.0006 | |
| SRP008496 | ISY1 | 57461 | RNAseq | 2.1748 | 0.0000 | |
| SRP064894 | ISY1 | 57461 | RNAseq | 0.8080 | 0.0009 | |
| SRP133303 | ISY1 | 57461 | RNAseq | 0.4976 | 0.0001 | |
| SRP159526 | ISY1 | 57461 | RNAseq | 0.2949 | 0.1829 | |
| SRP193095 | ISY1 | 57461 | RNAseq | 0.2793 | 0.0130 | |
| SRP219564 | ISY1 | 57461 | RNAseq | 0.2402 | 0.4255 | |
| TCGA | ISY1 | 57461 | RNAseq | 0.2479 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ISY1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ISY1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISY1 | 57461 | 17 | 0 | 13 | |
| GSE20123 | ISY1 | 57461 | 17 | 0 | 13 | |
| GSE43470 | ISY1 | 57461 | 19 | 0 | 24 | |
| GSE46452 | ISY1 | 57461 | 14 | 5 | 40 | |
| GSE47630 | ISY1 | 57461 | 18 | 3 | 19 | |
| GSE54993 | ISY1 | 57461 | 2 | 8 | 60 | |
| GSE54994 | ISY1 | 57461 | 32 | 3 | 18 | |
| GSE60625 | ISY1 | 57461 | 0 | 6 | 5 | |
| GSE74703 | ISY1 | 57461 | 17 | 0 | 19 | |
| GSE74704 | ISY1 | 57461 | 13 | 0 | 7 | |
| TCGA | ISY1 | 57461 | 58 | 5 | 33 |
Total number of gains: 207; Total number of losses: 30; Total Number of normals: 251.
Somatic mutations of ISY1:
Generating mutation plots.
Highly correlated genes for ISY1:
Showing top 20/542 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISY1 | PAPOLG | 0.804587 | 3 | 0 | 3 |
| ISY1 | PDRG1 | 0.789283 | 3 | 0 | 3 |
| ISY1 | SPNS1 | 0.786895 | 3 | 0 | 3 |
| ISY1 | NUP107 | 0.786578 | 3 | 0 | 3 |
| ISY1 | AP3M2 | 0.784366 | 3 | 0 | 3 |
| ISY1 | SSRP1 | 0.783704 | 3 | 0 | 3 |
| ISY1 | TOP1MT | 0.773777 | 3 | 0 | 3 |
| ISY1 | SEC22A | 0.769426 | 4 | 0 | 4 |
| ISY1 | TSN | 0.76172 | 4 | 0 | 4 |
| ISY1 | SSR3 | 0.755282 | 3 | 0 | 3 |
| ISY1 | HAS3 | 0.753489 | 3 | 0 | 3 |
| ISY1 | GTF2E2 | 0.751227 | 3 | 0 | 3 |
| ISY1 | FBXO21 | 0.750577 | 3 | 0 | 3 |
| ISY1 | IWS1 | 0.750374 | 3 | 0 | 3 |
| ISY1 | PSMC3IP | 0.747404 | 3 | 0 | 3 |
| ISY1 | RFC2 | 0.742639 | 4 | 0 | 4 |
| ISY1 | TRPC4AP | 0.74263 | 3 | 0 | 3 |
| ISY1 | C1orf50 | 0.742414 | 3 | 0 | 3 |
| ISY1 | BRCA1 | 0.740443 | 3 | 0 | 3 |
| ISY1 | EWSR1 | 0.736598 | 3 | 0 | 3 |
For details and further investigation, click here
